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    Glossary Vitamin D

    fat-soluble vitamin essential for calcium absorption and bone health

    Vitamin D is a fat-soluble vitamin that is crucial for maintaining healthy bones and teeth by aiding in the absorption of calcium and phosphorus from the gut. It can be obtained through exposure to sunlight, certain foods, and supplements. There are two main forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), with D3 being more effective at raising blood levels of the vitamin. Deficiency in vitamin D can lead to conditions such as rickets in children and osteomalacia in adults.

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    1. Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice Endocrine reviews · 2008 · 1533 citations
    2. The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed Journal of bone and mineral research · 1998 · 1308 citations
    3. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice<sup>1</sup> Endocrinology · 1998 · 519 citations
    4. Vitamin D Receptor: New Assignments for an Already Busy Receptor Endocrinology · 2006 · 510 citations
    5. Deletion of Deoxyribonucleic Acid Binding Domain of the Vitamin D Receptor Abrogates Genomic and Nongenomic Functions of Vitamin D Molecular Endocrinology · 2002 · 277 citations
    6. Vitamin D: More Than a “Bone-a-Fide” Hormone Molecular endocrinology · 2003 · 276 citations
    7. Vitamin D receptor: molecular signaling and actions of nutritional ligands in disease prevention Nutrition reviews · 2008 · 271 citations
    8. Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling Journal of Biological Chemistry · 2003 · 215 citations
    9. Evolution and Function of Vitamin D 2003 · 188 citations
    10. Vitamin D metabolism and function in the skin Molecular and cellular endocrinology · 2011 · 185 citations
    11. Lack of the Vitamin D Receptor is Associated with Reduced Epidermal Differentiation and Hair Follicle Growth 2002 · 180 citations
    12. Rickets with alopecia: An inborn error of vitaminD metabolism 1979 · 170 citations
    13. Behavioural characterization of Vitamin D receptor knockout mice Behavioural brain research · 2005 · 166 citations
    14. Vitamin D and the skin: Physiology and pathophysiology Reviews in endocrine and metabolic disorders · 2011 · 158 citations
    15. Genetic Disorders and Defects in Vitamin D Action Endocrinology and metabolism clinics of North America · 2010 · 151 citations
    16. Inactivation of the Vitamin D Receptor Enhances Susceptibility of Murine Skin to UV-Induced Tumorigenesis 2008 · 148 citations
    17. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004 · 144 citations
    18. Vitamin D receptor is essential for normal keratinocyte stem cell function Proceedings of the National Academy of Sciences · 2007 · 143 citations
    19. Vitamin D and the skin: Focus on a complex relationship: A review Journal of Advanced Research · 2014 · 139 citations
    20. Atrichia Caused by Mutations in the Vitamin D Receptor Gene is a Phenocopy of Generalized Atrichia Caused by Mutations in the Hairless Gene 2001 · 139 citations
    21. Vitamin D Receptor: Key Roles in Bone Mineral Pathophysiology, Molecular Mechanism of Action, and Novel Nutritional Ligands Journal of bone and mineral research · 2007 · 137 citations
    22. Metabolic and cellular analysis of alopecia in vitamin D receptor knockout mice Journal of Clinical Investigation · 2001 · 137 citations
    23. The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis PloS one · 2008 · 127 citations
    24. Extraskeletal actions of vitamin D Annals of the New York Academy of Sciences · 2016 · 119 citations
    25. Normalization of Mineral Ion Homeostasis by Dietary Means Prevents Hyperparathyroidism, Rickets, and Osteomalacia, But Not Alopecia in Vitamin D Receptor-Ablated Mice Endocrinology · 1998 · 119 citations
    26. Targeting Expression of the Human Vitamin D Receptor to the Keratinocytes of Vitamin D Receptor Null Mice Prevents Alopecia Endocrinology · 2001 · 115 citations
    27. Vitamin D and the Skin: An Update for Dermatologists American journal of clinical dermatology · 2017 · 114 citations
    28. Evaluation of Keratinocyte Proliferation and Differentiation in Vitamin D Receptor Knockout Mice* Endocrinology · 2000 · 114 citations
    29. Mechanism of Vitamin D Receptor Action Annals of the New York Academy of Sciences · 2006 · 111 citations
    30. The role of vitamin D receptor mutations in the development of alopecia Molecular and Cellular Endocrinology · 2011 · 109 citations