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    Glossary Tyrosine

    Tyrosine is an amino acid that plays a crucial role in the production of melanin, the pigment responsible for hair color, as well as neurotransmitters that can influence hair growth. It is relevant to hair loss as it is involved in the synthesis of proteins that are essential for healthy hair follicles. A deficiency in tyrosine may lead to changes in hair pigmentation and potentially impact hair growth cycles. Key distinguishing characteristics include its role as a precursor to important hormones and its presence in various dietary sources, such as dairy products, meats, and nuts.

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    1. Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects Current drug metabolism · 2009 · 508 citations
    2. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019 · 88 citations
    3. Tyrosine kinase inhibition and grey hair The Lancet · 2003 · 59 citations
    4. Unique Cutaneous Reaction to Second- and Third-Generation Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia Dermatology · 2015 · 32 citations
    5. Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle PloS one · 2015 · 31 citations
    6. Adverse cutaneous reactions to the new second-generation tyrosine kinase inhibitors (dasatinib, nilotinib) in chronic myeloid leukemia Journal of the American Academy of Dermatology · 2013 · 25 citations
    7. Characterisation of an Ovine Keratin Associated Protein (KAP) Gene, Which Would Produce a Protein Rich in Glycine and Tyrosine, but Lacking in Cysteine Genes · 2019 · 24 citations
    8. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    9. A Case of Inflammatory Nonscarring Alopecia Associated With the Tyrosine Kinase Inhibitor Nilotinib JAMA Dermatology · 2013 · 16 citations
    10. Screening of Tyrosinase, Xanthine Oxidase, and α-Glucosidase Inhibitors from Polygoni Cuspidati Rhizoma et Radix by Ultrafiltration and HPLC Analysis Molecules · 2023 · 12 citations
    11. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    12. Epitopes, avidity and IgG subclasses of tyrosine hydroxylase autoantibodies in vitiligo and alopecia areata patients British Journal of Dermatology · 2012 · 7 citations
    13. Repigmentation of leukoderma in a piebald patient associated with a novel c-KIT gene mutation, G592E, of the tyrosine kinase domain Journal of Dermatological Science · 2011 · 6 citations
    14. The microfibrillar proteins of human hair: Separation by high-performance liquid chromatography and isolation of some proteins enriched in glycine and tyrosine Analytical Biochemistry · 1987 · 2 citations
    15. Mechanism of Hair Curling via Laccase-Assisted Tyrosine Grafting Using BSA as a Model Protein Journal of Natural Fibers · 2023 · 1 citations
    16. 265 Modulation of disease-central cytokine pathways with TAK-279, a highly selective oral tyrosine kinase 2 (TYK2) inhibitor, defines clinical response in patients with psoriasis Journal of Investigative Dermatology · 2024 · 1 citations
    17. Tyrosine kinase Inhibitors in Dermatology: A Systemic Review Journal of dermatology and dermatitis · 2021 · 1 citations
    18. Plant‐Derived Monomers for Grey Hair Reversal Through Upregulation of Melanogenesis and Tyrosinase Activity Journal of Cellular and Molecular Medicine · 2025 · 1 citations
    19. Mechanism of Laccase-assisted Tyrosine Grafting on Keratin using BSA as a Model Protein Authorea (Authorea) · 2021
    20. Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in patients with alopecia areata: efficacy and safety results of a phase II, multicenter, randomized, double-blinded, placebo-controlled trial British Journal of Dermatology · 2026
    21. Cutaneous Adverse Events of Tyrosine Kinase Inhibitors in Endocrine Tumors: Clinical Features, Mechanisms, and Management Strategies Biomedicines · 2025
    22. Keratosis Pilaris-like Eruption during Treatment of Chronic Myeloid Leukemia with Tyrosine Kinase Inhibitors: Literature Review and Report of a Case Related to Imatinib Journal of clinical medicine · 2023
    23. 27 Preclinical ex vivo and in vivo evidence supporting selective inhibition of tyrosine kinase 2-dependent, IL-12-mediated signaling as a novel pharmacological strategy for alopecia areata management 2023
    24. 014 Tyrosine Kinase 2 Inhibition Ameliorates the Phenotype of Lesional Alopecia Areata Scalp Skin Ex Vivo, and Reverses the Induction of Human Alopecia Areata in a Humanized Mouse Model 2022
    25. 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model Journal of Investigative Dermatology · 2022
    26. 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy? Journal of Investigative Dermatology · 2021
    27. Tyrosine Kinase Inhibitors against Cancer: Their Safety in 216 Moroccan Patients Journal of Cancer Therapy · 2021
    28. Effets secondaires cutanéo-muqueux des nouvelles molécules anticancéreuses: Inhibiteurs de l'EGF-R, inhibiteurs de tyrosine kinase et stabilisateurs du fuseau mitotique 2011
    29. Characterisation, genomic organisation, expression and function of the mEphA1 receptor Tyrosine Kinase 2007
    30. Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency. PubMed · 1995 · 74 citations