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    Glossary Tyrosinase-Related Protein 2

    enzyme crucial for melanin production in hair and skin

    Tyrosinase-Related Protein 2 (TRP-2), also known as Dopachrome Tautomerase (DCT), is an enzyme involved in the production of melanin, the pigment responsible for hair, skin, and eye color. It plays a crucial role in the melanin biosynthesis pathway by converting dopachrome into dihydroxyindole-2-carboxylic acid (DHICA), which helps determine the type and amount of melanin produced. This protein is significant in studies related to pigmentation disorders and melanoma.

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    1. Efficacy of an agonist of<i>α</i>-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation International Journal of Cosmetic Science · 2018 · 12 citations
    2. Identification of immune microenvironment changes, immune-related pathways and genes in male androgenetic alopecia Medicine · 2023
    3. Optimization of the method for the culture of melanocyte precursors from hair follicles and their activation by 1,25-dihydroxyvitamin D3 Experimental and Therapeutic Medicine · 2013 · 7 citations
    4. Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia Research Square (Research Square) · 2023
    5. Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology PLOS ONE · 2022 · 7 citations
    6. Quercetin stimulates melanogenesis in hair follicle melanocyte of the mouse. PubMed · 2013 · 20 citations
    7. The Mechanisms of Fur Development and Color Formation in American Mink Revealed Using Comparative Transcriptomics Animals · 2022 · 1 citations
    8. Premature gray hair development in the interbrow region owing to the loss of maxillary first molars in young mice Genes to Cells · 2024
    9. Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport Journal of ethnopharmacology · 2023
    10. Life of the B10 Mouse: A View from the Hair Follicles and Tissue Stem Cells Cells tissues organs · 2023
    11. Supplementary Material for: Life of the B10 mouse: a view from the hair follicles and tissue stem cells Figshare · 2023
    12. 적하수오 에탄올 추출물의 melanin 합성 촉진효과 생명과학회지 · 2017
    13. El perquè del Palau Catalunya música: Revista musical catalana · 2008
    14. Changes in Characteristics of Murine Hair Follicles and Tissue Stem Cells Throughout Life SSRN Electronic Journal · 2022
    15. Exploring the potential effect and mechanisms of protocatechuic acid on human hair follicle melanocytes Acta pharmaceutica · 2020 · 3 citations
    16. 2,3,7,8‐Tetrachlorodibenzo‐<i>p</i>‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane Journal of Biochemical Toxicology · 1988 · 60 citations
    17. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    18. Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner Journal of Dermatological Science · 2016 · 10 citations
    19. All-trans retinoic acid induced the differentiation of amelanotic melanocytes of human hair follicle Linchuang pifuke zazhi · 2004
    20. Decision letter: Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness 2022
    21. Melanocyte Subpopulation Turnover During the Human Hair Cycle: An Immunohistochemical Study Pigment cell research · 2000 · 86 citations
    22. Coming of Age of Melanogenesis-Related Proteins Archives of Pathology & Laboratory Medicine · 2002 · 37 citations
    23. BIOCHEMICAL AND HISTOCHEMICAL STUDIES ON WHITE, BROWN AND BLACK SKIN REGIONS OF THE GUINEA PIG ACTA HISTOCHEMICA ET CYTOCHEMICA · 1973 · 2 citations
    24. Differential Gene Expression Screening Between Black and Gray Hairs Using Subtractive Library and DNA Chip Linchuang pifuke zazhi · 2004
    25. Pigmentation Effect of Rice Bran Extracted Minerals Comprising Soluble Silicic Acids Evidence-based Complementary and Alternative Medicine · 2016 · 11 citations
    26. The Effect of Butin on the Vitiligo Mouse Model Induced by Hydroquinone 2017 · 23 citations
    27. Anti-Melanogenic and Anti-Oxidative Effects of Nostoc verrucosum (ashitsuki) Extracts Cosmetics · 2023 · 6 citations
    28. Anti-melanogenic property of ginsenoside Rf from Panax ginseng via inhibition of CREB/MITF pathway in melanocytes and ex vivo human skin Journal of Ginseng Research · 2020 · 28 citations
    29. Human hair melanins: what we have learned and have not learned from mouse coat color pigmentation Pigment Cell & Melanoma Research · 2010 · 6 citations
    30. Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster International Journal of Molecular Sciences · 2016 · 18 citations