12 citations
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September 2018 in “International Journal of Cosmetic Science” This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.
September 2023 in “Medicine” This study found increased infiltration of specific immune cells, such as γδ T cells and CD8+ T cells, in the bald scalp of male androgenetic alopecia patients, and identified four key immune-related genes potentially involved in hair loss development through interferon-γ signaling pathways.
7 citations
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August 2013 in “Experimental and Therapeutic Medicine” In this study, the researchers optimized a method for culturing melanocyte precursors from hair follicles and found that 1,25-dihydroxyvitamin D3 significantly promotes their differentiation and melanin synthesis.
March 2023 in “Research Square (Research Square)” In this study, researchers found that changes in immune cell infiltration and immune-related gene expression may contribute to the immune microenvironment changes in male androgenetic alopecia.
7 citations
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May 2022 in “PLOS ONE” This study found that Hetian sheep with higher wool density produce more and finer wool, with key genes potentially influencing their wool growth and density.
20 citations
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December 2013 in “PubMed” This study found that quercetin increased melanin production in hair follicle tissues from C3H/HeN Jel mice, correlating with higher levels of tyrosinase protein and TRP-2 protein expression.
1 citations
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November 2022 in “Animals” This study found that differences in skin transcriptomes between juvenile and adult mink, as well as between black and white mink, suggest genes regulating hair color are active during early development rather than adulthood.
February 2024 in “Genes to Cells” This study observed that tooth loss in mice led to premature graying of hair in the interbrow region, which was possibly due to reduced stimulation of the trigeminal nerve, suggesting that decreased mastication could cause this type of hair graying.
December 2023 in “Journal of ethnopharmacology” This study found that tribuloside, a flavonoid from Tribulus terrestris L., enhances melanin production in human melanocytes, zebrafish, and human skin samples without causing toxicity, potentially through inhibiting PDE to increase cAMP levels and promote the melanin biosynthesis pathway.
September 2023 in “Cells tissues organs” In this study, researchers observed that in mice, as they age beyond 200 days, unusual curved hair follicles and increased white hairs emerge, indicating stem cell-related changes in keratinocyte and melanocyte characteristics, providing insights into hair aging processes.
January 2023 in “Figshare” This review discusses changes in hair follicle characteristics and stem cell dynamics as indicators of aging in mice, noting increased occurrences of white hairs and curved hair follicles at older ages.
This study found that Polygonum multiflorum radix ethanol extract may promote melanin synthesis, potentially helping to turn gray hair back to black by enhancing antioxidant activity and increasing tyrosinase expression.
January 2008 in “Catalunya música: Revista musical catalana” In this animal study, researchers observed that tooth loss in young mice led to premature gray hair growth in the interbrow area, likely due to reduced mastication affecting nerve input.
January 2022 in “SSRN Electronic Journal” This study reports that aging in mice leads to curved hair follicles and an increase in white hairs, potentially due to changes in keratinocyte and melanocyte stem cells.
3 citations
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May 2020 in “Acta pharmaceutica” The researchers reported that protocatechuic acid reduced melanin synthesis and enhanced antioxidant activity in cultured human hair follicle melanocytes, indicating potential for skin whitening applications.
60 citations
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December 1988 in “Journal of Biochemical Toxicology” In this study, TCDD administered to male rats down-regulated EGF receptor in liver plasma membranes and increased protein kinase activity, suggesting EGF receptor–mediated toxicological effects.
June 2023 in “Frontiers in Medicine” This study identified core genes and pathways involved in androgenetic alopecia, finding that genes related to hair follicle development are down-regulated, while those linked to immune responses are up-regulated, highlighting potential therapeutic targets.
10 citations
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May 2016 in “Journal of Dermatological Science” This study found that PDGF-BB affects human melanocytes differently depending on their differentiation stage, stimulating melanoblast proliferation but inhibiting melanocyte proliferation while promoting their differentiation.
January 2004 in “Linchuang pifuke zazhi” In this study, all-trans retinoic acid was found to promote differentiation and inhibit proliferation of amelanotic melanocytes from human hair follicles, suggesting a potential role in melanogenesis.
This study identified genetic regions evolving at different rates in hairless mammals, suggesting that specific genomic changes may contribute to the evolution of hairlessness across various species.
86 citations
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August 2000 in “Pigment cell research” This study observed that melanogenesis in human hair follicles is linked to anagen phases, with melanocyte activity and enzyme expression being region-specific to the nascent bulb.
37 citations
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July 2002 in “Archives of Pathology & Laboratory Medicine” The authors concluded that antibodies against tyrosinase and gp100 may be effective in diagnosing melanoma, including challenging variants like amelanotic and desmoplastic types, when appropriate antigen retrieval techniques are used.
2 citations
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January 1973 in “ACTA HISTOCHEMICA ET CYTOCHEMICA” In this study, the brown skin of guinea pigs exhibited higher levels of certain biochemical markers related to melanogenesis compared to black and white skin, with distinct differences in ascorbic acid utilization and protein concentrations observed between regions.
January 2004 in “Linchuang pifuke zazhi” This study identified specific genes that are more abundantly expressed in black hair than in gray hair, with black hair displaying higher expression of pigment-related proteins and gray hair showing increased expression of keratin-related genes.
11 citations
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January 2016 in “Evidence-based Complementary and Alternative Medicine” This study found that rice bran ash extract and orthosilicic acid both increased melanin synthesis and related protein expression in melanocytes, suggesting potential therapeutic use for melanin deficiency.
23 citations
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March 2017 in “PTR. Phytotherapy research/Phytotherapy research” This study in mice found that butin, a component of Vernonia anthelmintica, increased melanin production and related proteins while reducing oxidative stress markers in a model of hydroquinone-induced vitiligo, suggesting support for its traditional use against this condition.
6 citations
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February 2023 in “Cosmetics” This study found that hexane extracts of Nostoc verrucosum significantly inhibited melanin synthesis in melanoma cells and demonstrated antioxidant activity, suggesting potential use in developing cosmetic and functional food products.
28 citations
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December 2020 in “Journal of Ginseng Research” This study found that ginsenoside Rf from Panax ginseng may serve as an effective anti-pigmentation agent by inhibiting the CREB/MITF pathway, reducing melanogenesis in melanocytes and UV-irradiated human skin.
6 citations
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September 2010 in “Pigment Cell & Melanoma Research” This article discusses the roles of different proteins in melanogenesis and proposes a hypothesis to explain the diversity of human hair pigmentation, but it reports no new experimental results.
18 citations
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September 2016 in “International Journal of Molecular Sciences” This study reports that PDRN, commonly used for wound healing, may also have anti-melanogenesis and potential skin whitening effects in both experimental models and clinical settings.