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    Glossary Tyrosinase

    enzyme crucial for melanin production in skin and hair

    Tyrosinase is an enzyme that plays a crucial role in the production of melanin, the pigment responsible for the color of skin, hair, and eyes. It catalyzes the oxidation of tyrosine, an amino acid, into dopaquinone, which then undergoes further reactions to form melanin. This enzyme is significant in understanding conditions like albinism and vitiligo, where melanin production is affected.

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    1. Interaction between stem cell factor and endothelin-1: effects on melanogenesis in human skin xenografts Laboratory Investigation · 2006 · 27 citations
    2. Anti-Melanogenic and Anti-Oxidative Effects of Nostoc verrucosum (ashitsuki) Extracts Cosmetics · 2023 · 6 citations
    3. Regional differences in the distribution of melanocyte-containing hair bulbs in the skin of male albino rats PLoS ONE · 2025
    4. Premature gray hair development in the interbrow region owing to the loss of maxillary first molars in young mice Genes to Cells · 2024
    5. Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-associated Protein (KAP) Genes on Chromosome 21q22.1 2002 · 100 citations
    6. Integrated analysis of long non-coding RNA and mRNA expression in different colored skin of koi carp BMC Genomics · 2019 · 61 citations
    7. Platycladus orientalis Leaf Extract Promotes Hair Growth via Non-Receptor Tyrosine Kinase ACK1 Activation Current Issues in Molecular Biology · 2024
    8. Finasteride inhibited brain dopaminergic system and open-field behaviors in adolescent male rats CNS Neuroscience & Therapeutics · 2017 · 13 citations
    9. Quercetin stimulates melanogenesis in hair follicle melanocyte of the mouse. PubMed · 2013 · 20 citations
    10. Synergistic effect of rice bran extract and extremely low-frequency electromagnetic fields on dermal papilla/melanocytes in melanogenesis Bioelectromagnetics · 2018 · 6 citations
    11. The Peripheral Clock Regulates Human Pigmentation 2014 · 81 citations
    12. Anti-aging effects of black raspberry extract on cataract, alopecia, skin whitening, and weight loss Functional Foods in Health and Disease · 2018 · 10 citations
    13. Exploring the potential effect and mechanisms of protocatechuic acid on human hair follicle melanocytes Acta pharmaceutica · 2020 · 3 citations
    14. El perquè del Palau Catalunya música: Revista musical catalana · 2008
    15. Drug Repurposing Patent Applications April–June 2021 Assay and drug development technologies · 2021
    16. Desmodesmus pannonicus Water Extract Inhibits Melanin Synthesis and Promotes Wound Healing Life · 2024 · 1 citations
    17. The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation Experimental Dermatology · 2015 · 15 citations
    18. The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat Scientific Reports · 2018 · 13 citations
    19. 086 Evaluation of hair re-growth by cyclosporine and minoxidil using C3H mouse model Journal of Dermatological Science · 1995
    20. Optimization of the method for the culture of melanocyte precursors from hair follicles and their activation by 1,25-dihydroxyvitamin D3 Experimental and Therapeutic Medicine · 2013 · 7 citations
    21. Traditional Uses and Pharmacologically Active Constituents of Dendrobium Plants for Dermatological Disorders: A Review Natural Products and Bioprospecting · 2021 · 65 citations
    22. Effects of autologous platelet‑rich plasma injections on facial skin rejuvenation Experimental and Therapeutic Medicine · 2020 · 40 citations
    23. Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle PloS one · 2015 · 31 citations
    24. Melanocyte progenitor cells reside in human subcutaneous adipose tissue PLoS ONE · 2021 · 18 citations
    25. Novel Anti-Melanogenesis Properties of Polydeoxyribonucleotide, a Popular Wound Healing Booster International Journal of Molecular Sciences · 2016 · 18 citations
    26. Involvement of the central hypothalamic-pituitary-adrenal axis in hair growth and melanogenesis among different mouse strains PLoS ONE · 2018 · 6 citations
    27. Melanocyte Chitosan/Gelatin Composite Fabrication with Human Outer Root Sheath-Derived Cells to Produce Pigment Scientific Reports · 2019 · 5 citations
    28. Plant‐Derived Monomers for Grey Hair Reversal Through Upregulation of Melanogenesis and Tyrosinase Activity Journal of Cellular and Molecular Medicine · 2025 · 1 citations
    29. α-Mangostin, a safe and natural product as a candidate skin-whitening agent Scientific Reports · 2025
    30. Azelaic Acid in Dermatology: A Review of Its Mechanism of Action Cureus · 2025