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Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

The gene SDR5A1 is found in scalp hair of both hirsute and normal individuals, but it does not explain differences in hair growth.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.

Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Male yak hair growth is influenced by DHT synthesis, which is promoted by 5α-red1 and AR during growth phases, while E2 may inhibit growth through ERα.

Hirsute women have lower type 2 17β-HSD enzyme levels, which improve with treatment.

Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Dicentrine reduced heart disease risk factors in rats, T-588 protected mice brains without side effects, Provir blocked herpes virus and lessened mouse symptoms, and LY191704 could treat hair loss and prostate issues.

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.

Ganoderma lucidum, a type of mushroom, may help treat enlarged prostate by blocking testosterone conversion.

Some herbs and their components might help treat hair loss by affecting various biological pathways, but more research and regulation are needed.

Different drugs can treat high male hormone levels in women, but they have various effects and some may harm a fetus.

Dutasteride is more effective than finasteride for hair loss treatment.

Human sebaceous glands contain enzymes that affect androgen production and may influence sebum production and acne.

Dutasteride, usually used for prostate issues and hair loss, could potentially treat Amyotrophic Lateral Sclerosis (ALS) due to its neuroprotective, antioxidant, and anti-inflammatory properties, but more testing is needed.

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

LY320236 is a strong blocker of two enzymes that change testosterone into dihydrotestosterone and might help treat conditions related to male hormones.

Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.

Scientists made new substances that can block an enzyme linked to prostate issues and hair loss, with potential for creating a new treatment.

A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

5α reductase type 2 enzyme mutation and oxidative stress may increase androgenetic alopecia risk in Egyptians.