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    Glossary TRPV3

    protein channel involved in skin and hair follicle function

    TRPV3 is a protein that functions as an ion channel in the cell membranes of skin and hair follicle cells. It plays a crucial role in sensing temperature and chemical stimuli, and its proper function is essential for maintaining healthy skin and hair growth. Mutations in the TRPV3 gene can lead to skin disorders and hair loss conditions, making it a significant focus in dermatological and trichological research.

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    Research 30 of 361

    1. Localization of mechanosensitive channel TRPV4 in mouse skin Neuroscience Letters · 2003 · 123 citations
    2. TRPV3 as a Therapeutic Target for Itch Journal of Investigative Dermatology · 2012 · 88 citations
    3. Activation of TRPV3 Regulates Inflammatory Actions of Human Epidermal Keratinocytes Journal of Investigative Dermatology · 2017 · 77 citations
    4. TRPV1 Function in Health and Disease Current Pharmaceutical Biotechnology · 2010 · 65 citations
    5. Influence of TRPV3 mutation on hair growth cycle in mice Biochemical and Biophysical Research Communications · 2007 · 59 citations
    6. Olmsted Syndrome Caused by a Homozygous Recessive Mutation in TRPV3 Journal of Investigative Dermatology · 2014 · 56 citations
    7. Hair Cycle Control by Vanilloid Receptor-1 (TRPV1): Evidence from TRPV1 Knockout Mice Journal of Investigative Dermatology · 2006 · 49 citations
    8. Structural mechanism of TRPV3 channel inhibition by the plant‐derived coumarin osthole EMBO reports · 2021 · 28 citations
    9. Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses Journal of Investigative Dermatology · 2018 · 26 citations
    10. TRPV4 Is Expressed in Human Hair Follicles and Inhibits Hair Growth In Vitro Journal of Investigative Dermatology · 2018 · 25 citations
    11. Molecular determinants for the chemical activation of the warmth-sensitive TRPV3 channel by the natural monoterpenoid carvacrol Journal of Biological Chemistry · 2022 · 24 citations
    12. Mechanisms of proton inhibition and sensitization of the cation channel TRPV3 The Journal of General Physiology · 2020 · 15 citations
    13. TRPV Channels in Osteoarthritis: A Comprehensive Review Biomolecules · 2024 · 14 citations
    14. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes 2021 · 11 citations
    15. Unlocking the therapeutic potential of TRPV3: Insights into thermosensation, channel modulation, and skin homeostasis involving TRPV3 BioEssays · 2024 · 10 citations
    16. Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching 2015 · 7 citations
    17. Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair growth in mice Developmental Cell · 2024 · 5 citations
    18. A combination of low-dose systemic etretinate and topical calcipotriol/betamethasone dipropionate treatment for hyperkeratosis and itching in Olmsted syndrome associated with a TRPV3 mutation Journal of dermatological science · 2017 · 5 citations
    19. Transient stimulation of TRPV4‐expressing keratinocytes promotes hair follicle regeneration in mice British Journal of Pharmacology · 2020 · 4 citations
    20. Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine 2020 · 3 citations
    21. TRPV3 Ion Channel: From Gene to Pharmacology International Journal of Molecular Sciences · 2023 · 2 citations
    22. The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair International journal of molecular sciences · 2024 · 1 citations
    23. Cutaneous TRPV4 Potentiates the Afferent Transmission of Electroacupuncture Stimulation ACS Omega · 2026
    24. Nociceptive and Nonnociceptive Roles of TRPV3 and Its “Druggability” Methods in pharmacology and toxicology · 2012
    25. Natural phenylethanoid glycoside forsythoside A alleviates androgenetic alopecia by selectively inhibiting TRPV3 channels in mice European Journal of Pharmacology · 2025
    26. Pathogenesis and management of TRPV3-related Olmsted syndrome Frontiers in Genetics · 2024
    27. Case report: Novel p.Val306Met missense mutation in TRPV3 in a case of Olmsted syndrome accompanied by squamous cell carcinoma Frontiers in Oncology · 2024
    28. Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype BMC genomics · 2024
    29. Molecular studies of transient receptor potential Vanilloid 3 (TRPV3) OPAL (Open@LaTrobe) (La Trobe University) · 2024
    30. 738 Cryo-EM and molecular dynamics of TRPV3 channel in activated state reveal structural features implicated in severe itch and hyperkeratosis 2023