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    Glossary Transcriptional Activation

    process of increasing gene expression to produce more RNA

    Transcriptional activation is the process by which a cell increases the expression of a specific gene, leading to the production of more RNA and, subsequently, more protein from that gene. This is typically achieved through the binding of transcription factors to specific DNA sequences near the gene, which helps recruit the cellular machinery needed for transcription. For a layperson, think of it as turning up the volume on a specific instruction manual within the cell, so more copies of that instruction are made.

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    1. Transcriptional activation of CCN1 and CCN2, targets of canonical Wnt signal, by ascorbic acid 2-phosphate in human dermal papilla cells Journal of Dermatological Science · 2007 · 14 citations
    2. Transcriptional activation of a subset of hair keratin genes by the NF-κB effector p65/RelA Differentiation · 2007 · 7 citations
    3. The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function American Journal of Pathology · 2003 · 72 citations
    4. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours Nature · 1997 · 638 citations
    5. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    6. Androgen receptor activation integrates complex transcriptional effects in osteoblasts, involving the growth factors TGF-β and IGF-I, and transcription factor C/EBPδ Gene · 2015 · 11 citations
    7. Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain 2018 · 14 citations
    8. Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A case control study Skin Pharmacology and Physiology · 2022
    9. IN-SILICO STUDY OF BIOACTIVE COMPOUNDS OF NATURAL MATERIALS AS A JAK- SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION INHIBITOR FOR ANTI-ALOPECIA Asian journal of pharmaceutical and clinical research · 2017
    10. Melatonin Promotes the Development of Secondary Hair Follicles in Adult Cashmere Goats by Activating the Keap1-Nrf2 Signaling Pathway and Inhibiting the Inflammatory Transcription Factors NFκB and AP-1 International Journal of Molecular Sciences · 2023 · 1 citations
    11. SlPHL1, a MYB‐CC transcription factor identified from tomato, positively regulates the phosphate starvation response Physiologia Plantarum · 2021 · 11 citations
    12. Allosteric interactions prime androgen receptor dimerization and activation bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 1 citations
    13. Transcriptional profiling in alopecia areata defines immune and cell cycle control related genes within disease-specific signatures Genomics · 2010 · 61 citations
    14. 164 Epigenetic and transcriptional profiling of PBMCs in mild and severe alopecia areata using single-cell RNA-Seq and ATAC-Seq Journal of Investigative Dermatology · 2023
    15. Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells American journal of physiology. Cell physiology · 2006 · 56 citations
    16. Lack of androgen receptor transcriptional activity in human keratinocytes Journal of dermatological science · 2000 · 30 citations
    17. Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Hutchinson-Gilford Progeria Syndrome bioRxiv (Cold Spring Harbor Laboratory) · 2022 · 2 citations
    18. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014 · 175 citations
    19. Activation of the OVOL1-OVOL2 axis in the hair bulb and in pilomatricoma and pilomatrix carcinoma Journal of dermatological science · 2016
    20. Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer Biological & pharmaceutical bulletin · 2012 · 28 citations
    21. miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma Oncogene · 2021 · 30 citations
    22. Stress-induced c-Jun-dependent Vitamin D Receptor (VDR) Activation Dissects the Non-classical VDR Pathway from the Classical VDR Activity 2007 · 31 citations
    23. Optimization of the method for the culture of melanocyte precursors from hair follicles and their activation by 1,25-dihydroxyvitamin D3 Experimental and Therapeutic Medicine · 2013 · 7 citations
    24. Intermolecular NH2-/Carboxyl-terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity 1998 · 227 citations
    25. Discovery of Nonsteroidal Androgens Biochemical and biophysical research communications · 1998 · 209 citations
    26. Regulation of Keratin Gene Expression in Hair Follicle Differentiation<sup>a</sup> Annals of the New York Academy of Sciences · 1991 · 98 citations
    27. <i>In Vitro</i>and<i>in Vivo</i>Structure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring Endocrinology · 2005 · 20 citations
    28. Regulation of Involucrin Gene Expression Journal of Investigative Dermatology · 2004 · 138 citations
    29. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025
    30. Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells International Journal of Molecular Sciences · 2022 · 8 citations