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    Glossary Topical Dutasteride

    Topical Dutasteride is a formulation of the 5-alpha-reductase inhibitor Dutasteride, applied directly to the scalp to treat androgenetic alopecia (male and female pattern hair loss). It works by reducing the conversion of testosterone to dihydrotestosterone (DHT), a hormone linked to hair follicle miniaturization and hair loss. The topical application aims to minimize systemic side effects associated with oral administration while delivering the active ingredient directly to the hair follicles. Key distinguishing characteristics include its dual inhibition of both type I and type II 5-alpha-reductase enzymes, making it potentially more effective than other treatments that target only one type.

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    1. Comparative study between fractional CO2 laser alone versus fractional CO2 laser combined with topical dutasteride in treatment of male androgenic alopecia Lasers in Medical Science · 2025
    2. Topical dutasteride for androgenic alopecia: current state and prospects Therapeutic Delivery · 2024
    3. Microneedling plus topical dutasteride solution for androgenetic alopecia: a randomized placebo‐controlled study Journal of The European Academy of Dermatology and Venereology · 2022
    4. Topical dutasteride with microneedling in treatment of male androgenetic alopecia Sohag Medical Journal · 2018
    5. Engineered Dutasteride-Lipid Based Nanoparticle (DST-LNP) System Using Oleic and Stearic Acid for Topical Delivery Bioengineering · 2022 · 7 citations
    6. A Randomized, Double-Blind, Placebo and Active Controlled Phase II Study to Evaluate the Safety and Efficacy of Novel Dutasteride Topical Solution (0.01%, 0.02%, and 0.05% w/v) in Male Subjects With Androgenetic Alopecia Cureus · 2025
    7. Dutasteride Topical Gel Containing Herbal Extract for Male Pattern Baldness International Journal of Drug Delivery Technology · 2024
    8. Comparison between Topical Minoxidil 5% Alone versus Combined with Dutasteride (Topical 0.02% through Microneedling or Oral 0.5 mg) in Treatment of Androgenetic Alopecia QJM · 2024
    9. Preparation and characterization of dutasteride-loaded nanostructured lipid carriers coated with stearic acid-chitosan oligomer for topical delivery European Journal of Pharmaceutics and Biopharmaceutics · 2017 · 47 citations
    10. Novel iron oxide nanocarriers loading finasteride or dutasteride: Enhanced skin penetration for topical treatment of alopecia International Journal of Pharmaceutics · 2020 · 12 citations
    11. Development and Characterization of Dutasteride Bearing Liposomal Systems for Topical Use Current Drug Discovery Technologies · 2011 · 4 citations
    12. Frontal fibrosing alopecia: treatment with oral dutasteride and topical pimecrolimus Journal of The European Academy of Dermatology and Venereology · 2008 · 69 citations
    13. A Novel Topical Dutasteride Lotion (FOL100) for Male Pattern Baldness in Israeli Men: A Phase I Study of Safety, Tolerability, Usability, and Exploratory Efficacy Dermatologic Therapy · 2026
    14. Development and Evaluation of Dutasteride Nanoemulgel for the Topical Delivery against Androgenic Alopecia 2024
    15. Development of Ethosomes for the Topical Treatment of Androgenic Alopecia: Ethanol Effect on Dutasteride Targeting to the Hair Follicles Pharmaceutics · 2025
    16. Evaluation of Dutasteride-Loaded Liposomes and Transfersomes for Follicular-Targeting for Androgenic Alopecia Topical Treatment Pharmaceutics · 2024
    17. Comparative study between topical minoxidil 5% and oral spironolactone versus topical minoxidil 5% and oral dutasteride in the treatment of women with androgenic alopecia International Journal of Medical Arts · 2026
    18. Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System International Journal of Dermatology · 2025
    19. Dutasteride Micro-Injections in Androgenetic Alopecia Dermatología Cosmética, Médica y Quirúrgica · 2019
    20. Retrospective Pharmacotherapeutic Evaluation of Dutasteride not Approved by US FDA for Androgenetic Alopecia in Korea Korean Journal of Clinical Pharmacy · 2015
    21. Evaluation of the efficacy and safety of topical and oral treatments on hormonal and androgenetic alopecia Anales Médicos de la Asociación Médica del Centro Médico ABC · 2014
    22. Treatment of postmenopausal frontal fibrosing alopecia with oral dutasteride Journal of The American Academy of Dermatology · 2009 · 64 citations
    23. FR-Mesoterapia con dutasterida, una futura alternativa para el tratamiento de la alopecia androgenética Actas Dermo-Sifiliográficas · 2020 · 12 citations
    24. Nanotechnology-based topical treatments for androgenic alopecia Nanomedicine · 2025
    25. Efficacy and safety of dutasteride in the treatment of alopecia: a comprehensive review Expert Opinion on Pharmacotherapy · 2025
    26. Safety and efficacy of a topical treatment (SM04554) for androgenetic alopecia (AGA): Results from a phase 1 Trial Journal of The American Academy of Dermatology · 2016 · 2 citations
    27. Anti-hair loss and hair care properties from tropical halophyte, seablite (Suaeda maritima) root extract Research Journal of Pharmacy and Technology · 2024
    28. Frontal fibrosing alopecia: clinical and prognostic classification 2017 · 74 citations
    29. Nail involvement in frontal fibrosing alopecia International Journal of Trichology · 2015 · 17 citations
    30. Minimally Invasive Non-Surgical Therapies for Androgenetic Alopecia: A Narrative Review of Clinical Evidence for Regenerative and Locally Acting Antiandrogen Treatments Preprints.org · 2026