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    Glossary Topical Antiandrogens

    medications applied to skin to block androgen effects locally

    Topical antiandrogens are medications applied directly to the skin to block the effects of androgens, which are hormones that can contribute to conditions like acne, hirsutism (excessive hair growth), and androgenetic alopecia (pattern hair loss). By inhibiting these hormones locally, these treatments can help manage symptoms without the systemic side effects associated with oral antiandrogens.

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    1. New topical antiandrogenic formulations can stimulate hair growth in human bald scalp grafted onto mice International Journal of Pharmaceutics · 2000 · 37 citations
    2. Topical Antiandrogens Archives of Dermatology · 1985 · 11 citations
    3. Topical antiandrogens in the treatment of male-pattern baldness Clinics in dermatology · 1988 · 10 citations
    4. Topical Antiandrogen Therapies for Androgenetic Alopecia and Acne Vulgaris American Journal of Clinical Dermatology · 2019 · 7 citations
    5. Topical antiandrogens. What use in dermatology? Archives of Dermatology · 1985 · 5 citations
    6. Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen Organic Process Research & Development · 2017 · 9 citations
    7. Clascoterone: a new topical antiandrogen agent. Prospects in Pharmaceutical Sciences · 2025
    8. Assessment of the efficacy of topical antiandrogen; spironolactone in patients with androgenetic alopecia by dermoscopy Journal of Pakistan Association of Dermatologists · 2022
    9. RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 49 citations
    10. Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen Journal of the American Academy of Dermatology · 2012
    11. Topical Minoxidil Does Not Act as an Antiandrogen in the Flank Organ of the Golden Syrian Hamster Archives of Dermatology · 1987 · 26 citations
    12. Clinical applications of antiandrogens Journal of Steroid Biochemistry · 1988 · 29 citations
    13. The Future of Topical Therapy for Cutaneous Aging ˜The œJournal of dermatologic surgery and oncology · 1990 · 11 citations
    14. Biological Profile of Cortexolone 17a-Propionate (CB-03-01), a New Topical and Peripherally Selective Androgen Antagonist Drug Research · 2011 · 5 citations
    15. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 16 citations
    16. Pharmacology of Anti-androgens in the Skin Handbook of experimental pharmacology · 1989 · 1 citations
    17. Anti-androgen therapy in dermatology: a review Clinical and Experimental Dermatology · 1979 · 5 citations
    18. Anti-androgen therapy for the treatment of female pattern hair loss: a clinical review of current and emerging therapies Journal of the American Academy of Dermatology · 2025
    19. RU 58841-myristate–prodrug development for topical treatment of acne and androgenetic alopecia. PubMed · 2005 · 26 citations
    20. Antiandrogen Therapy for Female-Pattern Hair Loss NEJM Journal Watch · 2005
    21. Percutaneous absorption of a new antiandrogen included in liposomes or in solution International Journal of Pharmaceutics · 1995 · 20 citations
    22. Role of Anti-Androgens in the Management of Polycystic Ovary Syndrome (PCOS) Zenodo (CERN European Organization for Nuclear Research) · 2025
    23. Role of Anti-Androgens in the Management of Polycystic Ovary Syndrome (PCOS) Zenodo (CERN European Organization for Nuclear Research) · 2025
    24. Successful topical minoxidil treatment for hair density and length in trichorhinophalangeal syndrome type 1 Pediatric Dermatology · 2024
    25. Formulation and Evaluation of Minoxidil Loaded Submicron Emulsion Based Topical Gel for Treatment of Alopecia Azerbaijan Pharmaceutical and Pharmacotherapy J · 2023
    26. Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity Journal of Investigative Dermatology · 1995 · 37 citations
    27. Minimally Invasive Non-Surgical Therapies for Androgenetic Alopecia: A Narrative Review of Clinical Evidence for Regenerative and Locally Acting Antiandrogen Treatments Preprints.org · 2026
    28. Pattern Hair Loss in Men Dermatologic Clinics · 2012 · 58 citations
    29. Oral Contraceptives and Cyproterone Acetate in Female Acne Treatment Dermatology · 1998 · 30 citations
    30. Retrospective cohort study of CDK4/6-inhibitor-induced alopecia in breast cancer patients Supportive Care in Cancer · 2023 · 9 citations