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    Did you mean Terminal Differentiation?
    Glossary Terminal Differentiation

    cell's final development into a specialized, non-dividing state

    Terminal differentiation is the process by which a cell undergoes its final stage of development, becoming a specialized cell type with a specific function, such as a skin cell or a neuron. Once a cell has terminally differentiated, it typically loses the ability to divide and produce new cells, focusing instead on performing its specialized role. This process is crucial for the proper functioning of tissues and organs in the body.

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    1. Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression The FASEB Journal · 2003 · 51 citations
    2. Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation. The Journal of Cell Biology · 1994 · 104 citations
    3. 591 Chromatin architectural protein CTCF regulates terminal keratinocyte differentiation in the developing epidermis and hair follicles 2021
    4. The role of cathepsin E in terminal differentiation of keratinocytes Biological Chemistry · 2011 · 15 citations
    5. Autophagy-Mediated Cellular Remodeling during Terminal Differentiation of Keratinocytes in the Epidermis and Skin Appendages Cells · 2024 · 7 citations
    6. Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix European Journal of Cell Biology · 2017 · 30 citations
    7. Chapter 3 Expression and Modification of Keratins During Terminal Differentiation of Mammalian Epidermis 1987 · 81 citations
    8. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target during Hair Follicle and Nail Differentiation 2010 · 68 citations
    9. Two Mechanisms Regulate Keratin K15 Expression In Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signalling PloS one · 2012 · 35 citations
    10. N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting Journal of biomedical science · 2015 · 76 citations
    11. AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    12. The Process of Cornification Evolved From the Initial Keratinization in the Epidermis and Epidermal Derivatives of Vertebrates: A New Synthesis and the Case of Sauropsids International review of cell and molecular biology · 2016 · 73 citations
    13. Regulation of epidermal proliferation and hair follicle cycling by synthetic photostable retinoid EC23 Journal of cosmetic dermatology · 2023
    14. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells Developmental dynamics · 1994 · 253 citations
    15. Involucrin: A Constituent of Cross-Linked Envelopes and Marker of Squamous Maturation 1986 · 23 citations
    16. Selective Expression of Calcium-Binding Proteins S100A8 and S100A9 at Distinct Sites of Hair Follicles Journal of Investigative Dermatology · 2001 · 22 citations
    17. Pattern of expression of c-Myc, Max and Bin1 in human anagen hair follicles British Journal of Dermatology · 2001 · 11 citations
    18. Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C Differentiation · 2007 · 26 citations
    19. The Mixed Lineage Kinase Leucine-Zipper Protein Kinase Exhibits a Differentiation-Associated Localization in Normal Human Skin and Induces Keratinocyte Differentiation upon Overexpression Journal of Investigative Dermatology · 2000 · 17 citations
    20. Neutrophil gelatinase‐associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin Experimental dermatology · 2002 · 96 citations
    21. Cyclosporin A-induced hair growth in mice is associated with inhibition of calcineurin-dependent activation of NFAT in follicular keratinocytes American Journal of Physiology-cell Physiology · 2003 · 57 citations
    22. Epidermal keratinocyte stem cells: their maintenance and regulation Seminars in cell biology · 1992 · 25 citations
    23. Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation 2023
    24. Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis Frontiers in Bioscience-Landmark · 2022 · 12 citations
    25. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny Current Biology · 2001 · 338 citations
    26. Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alterations 2011 · 41 citations
    27. Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid‐treated culture of a newborn rat keratinocyte cell line FEBS Letters · 1998 · 39 citations
    28. Expression of the Orphan Protein Plet-1 during Trichilemmal Differentiation of Anagen Hair Follicles 2010 · 30 citations
    29. Ectopic Expression of the nude Gene Induces Hyperproliferation and Defects in Differentiation: Implications for the Self-Renewal of Cutaneous Epithelia Developmental biology · 1999 · 69 citations
    30. Lonely Hair Archives of Dermatology · 2011 · 63 citations