81 citations
,
June 2014 in “Cold Spring Harbor perspectives in medicine” This article discusses recent advances in understanding the mechanisms of tactile end organs in the epidermis and hair follicles from studies of mouse hairy skin, but it reports no new clinical results.
31 citations
,
November 2016 in “Cell Reports” This study reveals that somatosensory neurons in mouse skin exhibit structural plasticity during hair-follicle regeneration, which may temporarily impair the reliability of encoding gentle touch.
5 citations
,
August 2023 in “Skin Research and Technology” In this study, fMRI results suggested that mechanical stimulation evoked a stronger prickle sensation comprising both pain and itch on hairy skin compared to glabrous skin.
2 citations
,
October 2023 in “Science advances” In this study, researchers demonstrated that human hair follicle outer root sheath cells release ATP, serotonin, and histamine in response to mechanical stimulation, which subsequently activates surrounding sensory neurons.
1 citations
,
January 1992 in “Bangladesh Journal of Animal Science” This study examined camel skin histomorphology, finding that hair follicles were distributed singly in the upper lip but clustered in other body areas, and that sweat glands were associated only with large primary hairs.
October 2022 in “Hair Transplantation” This chapter outlines the sequential steps for using motorized follicular unit extraction machines with blunt punches in hair restoration, noting their advantages in minimizing follicle transection and providing tactile feedback.
1 citations
,
June 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This symposium discussed recent advances in understanding skin as a sensory organ, emphasizing the interactions between itch, pain, and touch pathways and highlighting potential therapeutic targets.
October 2025 in “Journal of Neurophysiology” In this study, researchers identified two types of potassium channels, BK and Kv4.2, in rat Merkel cells and reported that these channels play important roles in repolarizing action potentials and maintaining resting membrane potentials, potentially influencing tactile encoding in these cells.
April 2022 in “Journal of The American Academy of Dermatology” This article discusses scalp neuropathy in androgenetic alopecia and suggests that changes in tactile sensation due to Aβ fibers and increased nociception from circ-HTMR may be involved.
110 citations
,
January 1983 in “Brain Research Reviews” This study found that the vermilion border and mucosa of the monkey lip have a dense sensory innervation, which correlates with their known tactile sensitivity.
March 2006 in “The FASEB Journal” This study found that incorporating laminin or hair follicles into reconstructed skin grafts on mice improved nerve regeneration and sensory function, suggesting potential for enhancing tactile recovery in burn patients.
2 citations
,
October 2007 in “Kafrelsheikh Veterinary Medical Journal” This study examined the morphological features of buffalo lips, finding that their structure includes distinct layers of skin, muscle, connective tissue, and glands.
8 citations
,
February 2016 in “The American Journal of Dermatopathology” In this study, the researchers found that transplanted hair follicles undergo significant morphological changes, including a thickened dermal sheath and increased hair shaft diameter, which are associated with altered follicular vascularization.
2 citations
,
August 2019 in “Electronics and Communications in Japan” This study reports a highly sensitive MEMS silicon-hair device that mimics hair follicle functions by detecting minimal forces and moments, including electrostatic attraction and surface tension of liquids.
January 2026 in “Journal of Clinical Medicine” This study reviewed literature on the use of robotic systems in plastic and reconstructive surgery, highlighting their application in various procedures despite the predominance of descriptive case reports and a lack of comparative clinical outcomes and long-term data.
December 2025 in “Nature Communications” This study in male rats identified a unique type of mechanoreceptor, the club-like ending, which responds only to touch and not to self-motion during whisking, contrasting with other receptors that show mixed selectivity.
September 2023 in “Journal of the American Academy of Dermatology” A rare benign scalp tumor in an infant requires surgical removal.
February 2014 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)” In this rat model of diabetic neuropathic pain, the study found that testosterone metabolites dihydrotestosterone and 3α-diol may have analgesic effects through different mechanisms.
January 2016 in “Columbia Academic Commons (Columbia University)” This article explores the evolution of mechanosensing and discusses the diverse forms and organization of touch receptors but reports no new research findings.
This review discusses advances in understanding tickling sensations and proposes that knismesis hypersensitivity in autism spectrum disorder may be due to impaired sensory integration.
September 2024 in “Journal of the American Academy of Dermatology” This study reports that oxytocin receptor expression in keratinocytes shows a potential relationship with touch sensory neurons, suggesting a role in skin sensitivity and the broader function of sensory neurons.
63 citations
,
February 2010 in “Journal of Neurophysiology” This study observed that electrical stimulation of specific mechanoreceptive afferents in the orofacial region can evoke sensations consistent with their response properties, while others may require multiple afferents to access perceptual levels.
24 citations
,
March 2008 in “Neuroscience Research” This study revealed the complex three-dimensional innervation of touch domes in cat forepaw skin, highlighting the extensive branching and unmyelinated endings associated with Merkel cell–axon complexes.
660 citations
,
December 2011 in “Cell” This study found that distinct low-threshold mechanoreceptors innervate different hair follicle types in mice, suggesting that these follicles serve as unique mechanosensory structures in touch perception.
January 2000 in “Neuroscience Research” January 1981 in “Elsevier eBooks”
April 2018 in “Journal of Investigative Dermatology” This paper presents a new methodology combining magnetic tweezers and traction force microscopy to study keratinocyte mechanobiology, but reports no experimental results yet.
This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.
307 citations
,
November 1968 in “Journal of neurophysiology” Cats' hairy skin has different touch receptors connected by myelinated fibers.
1 citations
,
January 2001 in “PubMed” This study proposes that the terminal tuft structure in sensory nerve endings, involving Schwann cell processes and axon fingers, potentially plays a role in mechano-electric transduction in rats.