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    Glossary Stratum Corneum

    outermost skin layer composed of dead, keratinized cells

    The Stratum Corneum, also known as the Horny Layer, is the outermost layer of the epidermis, consisting of dead, flattened skin cells that are rich in keratin. This layer acts as a primary barrier to protect underlying tissues from infection, dehydration, and mechanical stress, playing a crucial role in maintaining skin hydration and overall health.

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    Research 30 of 1000+

    1. LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery Journal of Lipid Research · 2011 · 211 citations
    2. Development of Stratum Corneum Lipid Liposomes for Topical Drug Delivery International Journal of Drug Delivery Technology · 2026
    3. In vivo penetration of bare and lipid-coated silica nanoparticles across the human stratum corneum Colloids and surfaces. B, Biointerfaces · 2014 · 16 citations
    4. Nanostructured lipid carriers (NLCs) composed of argan oil, the potential novel vehicle for caffeine delivery to stratum corneum and hair follicles DOAJ (DOAJ: Directory of Open Access Journals) · 2022
    5. The stratum corneum barrier: impaired function in relation to associated lipids and proteins Tissue Barriers · 2024 · 7 citations
    6. Glycerol Regulates Stratum Corneum Hydration in Sebaceous Gland Deficient (Asebia) Mice Journal of Investigative Dermatology · 2003 · 216 citations
    7. Functional analysis of the stratum corneum of scalp skin: studies in patients with alopecia areata and androgenetic alopecia Archives of Dermatological Research · 2000 · 52 citations
    8. Stratum corneum dysfunction in dandruff International Journal of Cosmetic Science · 2012 · 93 citations
    9. Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure Langmuir · 2023 · 9 citations
    10. Investigation of the cutaneous penetration behavior of dexamethasone loaded to nano-sized lipid particles by EPR spectroscopy, and confocal Raman and laser scanning microscopy European journal of pharmaceutics and biopharmaceutics · 2016 · 21 citations
    11. Einfluss des Lipidmusters und der Morphologie der Epidermis auf transdermale Permeationsraten im In-vitro-Versuch 2007 · 1 citations
    12. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    13. Podophyllotoxin-loaded solid lipid nanoparticles for epidermal targeting Journal of controlled release · 2005 · 297 citations
    14. In Vitro, Ex Vivo, Penetration (EpiDermTM) and in Vivo Dermatokinetics of Ketoconazole Loaded Solid Lipid Nanoparticles for Topical Delivery Research Square (Research Square) · 2021 · 2 citations
    15. Lipid nanoparticles for topical and transdermal delivery of pharmaceuticals and cosmeceuticals Elsevier eBooks · 2018 · 2 citations
    16. Enhanced ex vivo skin retention of bicalutamide using a nano-in-micro composite: Drug-loaded lipid vesicles in a dissolving microarray patch European Journal of Pharmaceutics and Biopharmaceutics · 2025
    17. Determination of Solute Diffusion Properties in Artificial Sebum Journal of pharmaceutical sciences · 2019 · 6 citations
    18. Scalp Biophysical Characteristics in Males with Androgenetic Alopecia: A Comparative Study with Healthy Controls Clinical Interventions in Aging · 2021 · 12 citations
    19. 火针联合水杨酸对痤疮患者皮肤屏障功能及微生态的影响(The impact of fire needle therapy combined with salicylic acid on the skin barrier function and microecology of patients with acne) 中医药研究与应用(Research and application of traditional Chinese medicine) · 2025
    20. Comparison of rheological properties, follicular penetration, drug release, and permeation behavior of a novel topical drug delivery system and a conventional cream European journal of pharmaceutics and biopharmaceutics · 2014 · 34 citations
    21. Formation and Structure of Human Hair Birkhäuser Basel eBooks · 1995 · 175 citations
    22. Transferosomes: Unique vesicular carriers for effective transdermal delivery Journal of Applied Pharmaceutical Science · 2021 · 17 citations
    23. High spatial resolution study of human skin using synchrotron infrared microscopy: application to the penetration of external agents International Journal of Cosmetic Science · 2004 · 1 citations
    24. Transdermal Liposomal Delivery Systems: Advantages, Applications, Challenges, and Prospects MedComm – Biomaterials and Applications · 2025
    25. Does dry skin indicate defective epidermal permeability barrier? Chinese Journal of Dermatology · 2022
    26. Epidermal Barrier Cosmetic Dermatology · 2022
    27. ZNF750 safeguards upper hair follicle homeostasis to prevent inflammatory skin disease Journal of Investigative Dermatology · 2026
    28. Novel insights into ascorbic acid skin permeation 2020
    29. Biocompatible nanoparticles and vesicular systems in transdermal drug delivery for various skin diseases International Journal of Pharmaceutics · 2018 · 151 citations
    30. Delivery and targeting of nanoparticles into hair follicles Therapeutic Delivery · 2014 · 94 citations