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    Did you mean Steroid Metabolism?
    Glossary Steroid Metabolism

    process of breaking down and converting steroid hormones

    Steroid metabolism refers to the process by which the body breaks down and converts steroid hormones, such as cortisol, testosterone, and estrogen, into other substances. This involves a series of biochemical reactions primarily in the liver, where enzymes modify the steroid molecules to make them more water-soluble, allowing for their excretion through urine or bile. Understanding steroid metabolism is crucial for both diagnosing and treating conditions related to hormone imbalances and for the development of steroid-based medications.

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    1. Effects of mitotane treatment on human steroid metabolism: implications for patient management Endocrine Connections · 2012 · 26 citations
    2. Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis Journal of Autoimmunity · 2024 · 20 citations
    3. 5α-Reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis Hormone Molecular Biology and Clinical Investigation · 2014 · 15 citations
    4. Ovine placental steroid synthesis and metabolism in late gestation† Biology of reproduction · 2018 · 9 citations
    5. Gender-specific alteration of steroid metabolism and its impact on viral replication in a mouse model of hepatitis B virus infection Animal Cells and Systems · 2024 · 2 citations
    6. Dendrobium officinale polysaccharide improves hair regrowth in androgenetic alopecia mice and is associated with coordinated changes in local steroid metabolism, ESR1 activation, and keratin-related follicular responses Frontiers in Pharmacology · 2026
    7. Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism 2001 · 115 citations
    8. 24-Hydroxycholesterol suppresses steroid 5α-reductase-catalyzed conversion in human glioblastoma cell lines: A novel link between brain cholesterol homeostasis and androgen metabolism Neurochemistry International · 2026
    9. Distinctive features of steroid hormone metabolism in female patients with androgenic alopecia Vestnik dermatologii i venerologii · 2013
    10. OR20-01 Machine Learning-based Steroid Metabolome Analysis In Women With Polycystic Ovary Syndrome Reveals Three Distinct Androgen Excess Subtypes With Different Metabolic Risk Profiles. Journal of the Endocrine Society · 2023
    11. Insulin administration alters gonadal steroid metabolism independent of changes in gonadotropin secretion in insulin-resistant women with the polycystic ovary syndrome. Journal of Clinical Investigation · 1989 · 202 citations
    12. Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine The Journal of Clinical Pharmacology · 1993 · 9 citations
    13. Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans Biomedical Chromatography · 2026
    14. Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite The Journal of Steroid Biochemistry and Molecular Biology · 1994 · 16 citations
    15. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro The Journal of Steroid Biochemistry and Molecular Biology · 2019 · 7 citations
    16. Relationship Between Steroid Hormones and Metabolic Profile in Women With Polycystic Ovary Syndrome Physiological Research · 2019 · 13 citations
    17. Sexual dimorphism of growth plate prehypertrophic and hypertrophic chondrocytes in response to testosterone requires metabolism to dihydrotestosterone (DHT) by steroid 5‐alpha reductase type 1 Journal of Cellular Biochemistry · 2005 · 27 citations
    18. Machine learning-based steroid metabolome analysis reveals three distinct subtypes of polycystic ovary syndrome and implicates 11-oxygenated androgens as major drivers of metabolic risk Endocrine Abstracts · 2023 · 3 citations
    19. Doping-Control Analysis of the 5α-Reductase Inhibitor Finasteride: Determination of Its Influence on Urinary Steroid Profiles and Detection of Its Major Urinary Metabolite Therapeutic Drug Monitoring · 2007 · 39 citations
    20. Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies Psychopharmacology · 2014 · 34 citations
    21. Rare and common genetic determinants of metabolic individuality and their effects on human health Nature Medicine · 2022 · 29 citations
    22. Development of a Liquid Chromatography/Mass Spectrometry-Based Inhibition Assay for the Screening of Steroid 5-α Reductase in Human and Fish Cell Lines Molecules · 2021 · 3 citations
    23. Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women Bioscience Reports · 2020 · 1 citations
    24. Serum and hair steroid profiles and their associations with body composition in adolescence European Journal of Endocrinology · 2025
    25. 923 Molecular phenotyping of lichen planopilaris revealed dysregulation of cholesterol/fatty acid metabolism, fibrosis and mast cell pathways Journal of Investigative Dermatology · 2019
    26. Urinary steroid analysis of women with effluvium Chromatographia · 1998
    27. Untargeted Metabolomics and Steroid Signatures in Urine of Male Pattern Baldness Patients after Finasteride Treatment for a Year Metabolites · 2020 · 8 citations
    28. Calcineurin-based immunosuppression in renal transplantation : focus on efficacy, the role of steroids, and the cardiovascular risk 2006
    29. A randomized placebo-controlled study on the effects of pioglitazone on cortisol metabolism in polycystic ovary syndrome Fertility and sterility · 2008 · 24 citations
    30. Transcriptome Analysis Reveals Skin Lipid Metabolism Related to Wool Diameter in Sheep bioRxiv (Cold Spring Harbor Laboratory) · 2016 · 10 citations