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    Glossary Steroid Sulfatase

    enzyme that converts sulfated steroids into active forms

    Steroid Sulfatase (STS) is an enzyme that plays a crucial role in the metabolism of steroid hormones by converting sulfated steroid precursors into their active forms. This process is important for the regulation of various physiological functions, including skin health, hair growth, and reproductive processes. Deficiencies or mutations in the STS gene can lead to conditions such as X-linked ichthyosis, which is characterized by dry, scaly skin.

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    1. Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition Endocrine Reviews · 2005 · 451 citations
    2. Steroid Sulfatase Deficiency and Androgen Activation Before and After Puberty The Journal of Clinical Endocrinology & Metabolism · 2016 · 41 citations
    3. Roles of steroid sulfatase in brain and other tissues Physiological Research · 2008 · 22 citations
    4. Steroid sulfatase inhibitors Medicinal Research Reviews · 2004 · 108 citations
    5. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001 · 61 citations
    6. Estrogenic Potential of 2-Alkyl-4-(thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2003 · 37 citations
    7. Steroid sulfatase inhibitors Expert Opinion on Therapeutic Patents · 2003 · 25 citations
    8. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    9. Banding Pattern on Polarized Hair Microscopic Examination and Unilateral Polymicrogyria in a Patient With Steroid Sulfatase Deficiency Archives of dermatology · 2011 · 13 citations
    10. Steroid-resistant nephrotic syndrome associated with steroid sulfatase deficiency—x-linked recessive ichthyosis: a case report and review of literature European Journal of Pediatrics · 2012 · 7 citations
    11. Steroid sulfatase inhibitors Expert Opinion on Therapeutic Patents · 2003 · 1 citations
    12. 2-Substituted 4-(Thio)chromenone 6-<i>O</i>-Sulfamates: Potent Inhibitors of Human Steroid Sulfatase Journal of Medicinal Chemistry · 2002 · 111 citations
    13. N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase Bioorganic & Medicinal Chemistry Letters · 2004 · 17 citations
    14. Sulfatase inhibitors: a patent review Expert Opinion on Therapeutic Patents · 2012 · 47 citations
    15. Role of cholesterol sulfate in epidermal structure and function: Lessons from X-linked ichthyosis Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2014 · 87 citations
    16. Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination Current Opinion in Chemical Biology · 2008 · 83 citations
    17. LC‐MS/MS‐based method for long‐term steroid profiling in human scalp hair Clinical Endocrinology · 2015 · 134 citations
    18. A Virilizing Malignant Steroid Cell Tumor-Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Challenging Histopathological and Biochemical Features: A Case Report Research Square (Research Square) · 2023
    19. A Virilizing Malignant Steroid Cell Tumor-Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Challenging Histopathological and Biochemical Features: A Case Report Research Square (Research Square) · 2023
    20. MON-024 Steroid Cell Tumor, Not Otherwise Specified; A Rare Case of Hyperandrogenism Journal of the Endocrine Society · 2020
    21. Local synthesis and effect of sex steroids in human skin and the hair follicle and hormonal effects on the wound healing response Padua Research Archive (University of Padua) · 2011
    22. Study on Changes of 19 Steroids in Plasma From 9 Diagnosed Patients With P450 Oxidoreductase Deficiency Research Square (Research Square) · 2021
    23. Enzymology of the hair follicle. PubMed · 2001 · 31 citations
    24. Male-Pattern Baldness in Men with X-Linked Recessive Ichthyosis Dermatology · 2000 · 16 citations
    25. Targets to treat androgen excess in polycystic ovary syndrome Expert Opinion on Therapeutic Targets · 2015 · 14 citations
    26. Idiopathic hirsutism: Is it really idiopathic or is it misnomer? World Journal of Clinical Cases · 2023 · 11 citations
    27. Absence of Male-Pattern Baldness in Men with X-Linked Recessive Ichthyosis? Dermatology · 1999 · 9 citations
    28. Male-Pattern Baldness Is Common in Men with X-Linked Recessive Ichthyosis Dermatology · 2003 · 6 citations
    29. Investigational medications in the treatment of alopecia Expert Opinion on Investigational Drugs · 2005 · 3 citations
    30. Androgen Receptors and Androgen-Dependent Initiation of Protein Synthesis in the Prostate Vitamins and hormones · 1976 · 59 citations