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    Did you mean Steroid 5 Alpha-Reductase 2?
    Glossary Steroid 5 Alpha-Reductase 2

    enzyme converting testosterone to potent androgen dihydrotestosterone (DHT)

    Steroid 5 Alpha-Reductase 2 (also known as 5α-Reductase Type 2 or SRD5A2) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen. This enzyme plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and benign prostatic hyperplasia.

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    1. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    2. HPLC Profiling and Insilco studies of Chochurus olitoris (Jute) Leave Fractions against Steroid 5α-Reductase 2 (SRD5α2) Biomedical Journal of Scientific & Technical Research · 2024
    3. Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur Scientific reports · 2023
    4. In Vivo Time-Dependent Inhibition of Human Steroid 5a-Reductase by Finasteride Journal of Pharmaceutical Sciences · 1996 · 29 citations
    5. Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase Tetrahedron Letters · 1995 · 20 citations
    6. Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates General and Comparative Endocrinology · 2020 · 21 citations
    7. Rat steroid 5α-reductase kinetic characteristics: Extreme pH-dependency of the type II isozyme in prostate and epididymis homogenates The Journal of Steroid Biochemistry and Molecular Biology · 1995 · 13 citations
    8. Benzo[<i>c</i>]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000 · 28 citations
    9. Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors Assay and Drug Development Technologies · 2018 · 11 citations
    10. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, <i>In Vitro</i>, and <i>In Silico</i> Studies ACS Omega · 2025
    11. Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase Journal of Medicinal Chemistry · 1993 · 89 citations
    12. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011 · 218 citations
    13. Fast Motions in 5 Alpha Reductase and Its Impact on Enzyme Kinetics ACS Catalysis · 2026
    14. Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice 2017 · 16 citations
    15. Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome The Journal of Clinical Endocrinology & Metabolism · 2016 · 40 citations
    16. 5α-Reductase underscores the development of pectoral fin breeding tubercles in zebrafish Communications Biology · 2026
    17. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition Psychoneuroendocrinology · 2018 · 37 citations
    18. Docking and Molecular Dynamics Identify Leads against 5 Alpha Reductase 2 for Benign Prostate Hyperplasia Treatment Journal of Chemistry · 2023 · 10 citations
    19. Species Differences in Prostatic Steroid 5<i>α</i>-Reductases of Rat, Dog, and Human Endocrinology · 1985 · 193 citations
    20. A New Look at the 5á-Reductase Inhibitor Finasteride 2006
    21. Steroid Hormones Elsevier eBooks · 2016 · 3 citations
    22. 5α-Reductases in Human Physiology: An Unfolding Story Endocrine Practice · 2012
    23. Steroid Chemistry and Hormone Controls during the Hair Follicle Cycle Annals of the New York Academy of Sciences · 1991 · 34 citations
    24. Physiopathological role of the enzymatic complex 5α-reductase and 3α/β-hydroxysteroid oxidoreductase in the generation of progesterone and testosterone neuroactive metabolites Frontiers in Neuroendocrinology · 2020 · 18 citations
    25. Identification of xenobiotics interfering with 5 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="d1e152" altimg="si21.svg"> <mml:mi>α</mml:mi> </mml:math> -reductase (SRD5A2) activity Toxicology Letters · 2026
    26. 5-alpha reductase inhibitors: New evidences on benefits and harms beyond benign prostatic hyperplasia Actas urológicas españolas · 2018
    27. Inhibition of 5α Reductase Impairs Cognitive Performance, Alters Dendritic Morphology and Increases Tau Phosphorylation in the Hippocampus of Male 3xTg-AD Mice Neuroscience · 2020 · 13 citations
    28. Effect of <i>Ficus carica</i> leaf extract on the gene expression of selected factors in HaCaT cells Journal of Cosmetic Dermatology · 2017 · 16 citations
    29. Skin steroidogenesis in health and disease Reviews in endocrine and metabolic disorders · 2016 · 47 citations
    30. In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients Molecules · 2022 · 8 citations