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    Did you mean Steroid 5 Alpha-Reductase 2?
    Glossary Steroid 5 Alpha-Reductase 2

    enzyme converting testosterone to potent androgen dihydrotestosterone (DHT)

    Steroid 5 Alpha-Reductase 2 (also known as 5α-Reductase Type 2 or SRD5A2) is an enzyme that converts testosterone into dihydrotestosterone (DHT), a more potent androgen. This enzyme plays a crucial role in the development of male characteristics and is also implicated in conditions like male pattern baldness and benign prostatic hyperplasia.

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    1. Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors Medicinal Chemistry Research · 2017 · 12 citations
    2. Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors Assay and Drug Development Technologies · 2018 · 11 citations
    3. Intraethnic variation in steroid-5-alpha-reductase polymorphisms in prostate cancer patients: a potential factor implicated in 5-alpha-reductase inhibitor treatment 2015 · 4 citations
    4. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations
    5. Screen steroid 5 alpha-reductase inhibitors in vitro by high performance liquid chromatography Fuzhou daxue xuebao. Ziran kexue ban · 2005
    6. Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase Journal of Medicinal Chemistry · 1993 · 89 citations
    7. Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque. The Journal of Clinical Endocrinology and Metabolism · 1992 · 34 citations
    8. Geographic Influence and Metabolomics-Driven Discovery of 5-Alpha Reductase Inhibitors in Tectona grandis L.f. (Teak) Leaves Molecules · 2025
    9. 5 Alpha-Reductase Inhibitor Definitions · 2020
    10. Synthesis, Biological Evaluation and Molecular Docking of Avicequinone C Analogues as Potential Steroid 5α-Reductase Inhibitors Chemical & Pharmaceutical Bulletin · 2017 · 13 citations
    11. Synthesis and Biological Evaluation of 4-(4-(Alkyl-and Phenylaminocarbonyl)benzoyl)benzoic Acid Derivatives as Non-steroidal Inhibitors of Steroid 5α-Reductase Isozymes 1 and 2 Archiv Der Pharmazie · 2002 · 8 citations
    12. Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells Pharmaceutical biotechnology · 2004
    13. Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase Helvetica Chimica Acta · 1995 · 8 citations
    14. Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase Tetrahedron Letters · 1995 · 20 citations
    15. 3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1 Bioorganic & medicinal chemistry letters · 2007 · 13 citations
    16. Benzo[<i>c</i>]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1 Journal of Medicinal Chemistry · 2000 · 28 citations
    17. Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, <i>InVitro</i>, and <i>In Silico</i> Studies OPAL (Open@LaTrobe) (La Trobe University) · 2025
    18. The connection of 5-alpha reductase inhibitors to the development of depression Biomedicine & Pharmacotherapy · 2021 · 4 citations
    19. Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1 Bioorganic & medicinal chemistry · 2018 · 3 citations
    20. Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men. The Journal of Clinical Endocrinology and Metabolism · 1995 · 15 citations
    21. Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, <i>In Vitro</i>, and <i>In Silico</i> Studies ACS Omega · 2025
    22. Screening of steroid 5-reductase inhibitory activity and total phenolic content of Thai plants Journal of Medicinal Plants Research · 2011
    23. Patent Evaluation: Δ-4,6-Steroids as Potent 5α-Reductase Inhibitors Current opinion in therapeutic patents · 1992
    24. Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition Psychoneuroendocrinology · 2018 · 37 citations
    25. Finasteride, a 5alpha-reductase inhibitor, blocks the anticonvulsant activity of progesterone in mice. PubMed · 1999 · 48 citations
    26. Synthesis and Study of Some 17a-aza-D-homo Steroids as 5α-Reductase Inhibitors Current Drug Discovery Technologies · 2020 · 1 citations
    27. Novel 5α-Reductase Inhibitors:  Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids Journal of Medicinal Chemistry · 2005 · 18 citations
    28. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011 · 218 citations
    29. Comprehensive Evaluation of <i>Tectona grandis</i> L.f.: Integrated <i>In Vitro</i> and <i>In Silico</i> Analysis of Steroid 5α-Reductase Inhibition and Anti-Inflammatory Properties ACS Omega · 2025
    30. Homology Modeling of 5-alpha-Reductase 2 Using Available Experimental Data Interdisciplinary sciences: computational life sciences · 2018 · 5 citations