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    Glossary Stem Cell Maintenance

    processes ensuring stem cells stay healthy and self-renewing

    Stem cell maintenance refers to the processes that ensure stem cells remain healthy, functional, and capable of self-renewal over time. This involves a balance of signals and environmental conditions that prevent stem cells from differentiating prematurely, allowing them to continue producing new cells as needed for tissue repair and regeneration. For professionals, it encompasses understanding the molecular pathways and niche interactions that regulate stem cell quiescence, proliferation, and differentiation.

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    1. Novel complex of cosmetic ingredients with promising action in preventing hair loss and follicular aging through mechanism involving enrichment of <i>WNT</i>/signaling, mitochondrial activity, and stem cells maintenance Journal of Cosmetic Dermatology · 2020 · 8 citations
    2. Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling 2012 · 16 citations
    3. Development and Maintenance of Epidermal Stem Cells in Skin Adnexa International journal of molecular sciences · 2020 · 15 citations
    4. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    5. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance 2019 · 11 citations
    6. Epidermal keratinocyte stem cells: their maintenance and regulation Seminars in cell biology · 1992 · 25 citations
    7. Melanocyte Stem Cell Maintenance and Hair Graying Cell · 2005 · 105 citations
    8. Distinct stem cells contribute to mammary gland development and maintenance Nature · 2011 · 721 citations
    9. Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche Journal of dermatological science · 2016
    10. Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche Yearbook of Dermatology and Dermatologic Surgery · 2006
    11. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020 · 51 citations
    12. B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance Cell Reports · 2012 · 26 citations
    13. BMI1 is required for melanocyte stem cell maintenance and hair pigmentation Pigment Cell & Melanoma Research · 2023 · 4 citations
    14. Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo PLoS ONE · 2025
    15. 231 Novel protocol for the invitro maintenance and expansion of adult epidermal LGR5+ stem cells Reproduction Fertility and Development · 2019
    16. 244 Defective maintenance of hair follicle stem cells through COL17A1 loss orchestrates the hair follicle aging program Journal of Investigative Dermatology · 2017
    17. Multi‐tasking epidermal stem cells: Beyond epidermal maintenance Development, Growth & Differentiation · 2018 · 23 citations
    18. Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity Nature Reviews Molecular Cell Biology · 2023 · 200 citations
    19. Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors International Journal of Molecular Medicine · 2013 · 56 citations
    20. The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but not for Maintenance of the Epidermal Stem Cell Compartment 2008 · 25 citations
    21. ROR2 regulates self-renewal and maintenance of hair follicle stem cells Nature Communications · 2022 · 16 citations
    22. The TRF1 telomere protein is essential for the generation and maintenance of iPS cells and marks both pluripotent and adult stem cells edoc (University of Basel) · 2013
    23. Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential Clinical and Translational Medicine · 2024 · 27 citations
    24. MEX3A regulates <i>Lgr5</i> <sup>+</sup> stem cell maintenance in the developing intestinal epithelium EMBO Reports · 2020 · 27 citations
    25. Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration Digital Commons - RU (Rockefeller University) · 2025
    26. The Role of Cell Polarity Regulator aPKC in Hair Follicle Stem Cell Maintenance and Wound Healing Nihon Ika Daigaku Igakkai Zasshi · 2020
    27. Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal npj Regenerative Medicine · 2017 · 37 citations
    28. Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells Developmental biology · 2007 · 25 citations
    29. 1321 Low temperature and mTOR inhibition favor human epidermal stem cell maintenance Journal of Investigative Dermatology · 2023
    30. Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations