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    Glossary Stem Cell Maintenance

    processes ensuring stem cells stay healthy and self-renewing

    Stem cell maintenance refers to the processes that ensure stem cells remain healthy, functional, and capable of self-renewal over time. This involves a balance of signals and environmental conditions that prevent stem cells from differentiating prematurely, allowing them to continue producing new cells as needed for tissue repair and regeneration. For professionals, it encompasses understanding the molecular pathways and niche interactions that regulate stem cell quiescence, proliferation, and differentiation.

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    1. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    2. Melanocyte Stem Cell Maintenance and Hair Graying Cell · 2005 · 105 citations
    3. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance 2019 · 11 citations
    4. Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche Yearbook of Dermatology and Dermatologic Surgery · 2006
    5. Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle Cell Metabolism · 2020 · 51 citations
    6. BMI1 is required for melanocyte stem cell maintenance and hair pigmentation Pigment Cell & Melanoma Research · 2023 · 4 citations
    7. Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo PLoS ONE · 2025
    8. Regulation of adult stem cell quiescence and its functions in the maintenance of tissue integrity Nature Reviews Molecular Cell Biology · 2023 · 200 citations
    9. B-Raf and C-Raf Are Required for Melanocyte Stem Cell Self-Maintenance Cell Reports · 2012 · 26 citations
    10. The Vitamin D Receptor Is Required for Mouse Hair Cycle Progression but not for Maintenance of the Epidermal Stem Cell Compartment 2008 · 25 citations
    11. Analysis on the maintenance mechanisms of human interfollicular epidermal stem cell and their niche Journal of dermatological science · 2016
    12. The Role of Cell Polarity Regulator aPKC in Hair Follicle Stem Cell Maintenance and Wound Healing Nihon Ika Daigaku Igakkai Zasshi · 2020
    13. Transcriptional Governance of Hair Follicle Stem Cell Quiescence and Niche Maintenance in Long-Term Tissue Regeneration Digital Commons - RU (Rockefeller University) · 2025
    14. MEX3A regulates <i>Lgr5</i> <sup>+</sup> stem cell maintenance in the developing intestinal epithelium EMBO Reports · 2020 · 27 citations
    15. Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal npj Regenerative Medicine · 2017 · 37 citations
    16. Differential expression levels of Sox9 in early neocortical radial glial cells regulate the decision between stem cell maintenance and differentiation bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    17. 1321 Low temperature and mTOR inhibition favor human epidermal stem cell maintenance Journal of Investigative Dermatology · 2023
    18. Adipocyte-Derived Amino Acid Storage Proteins are Required for Germline Stem Cell Maintenance in Adult <i>Drosophila</i> Females 2025
    19. Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance Open Archive (Karolinska Institutet) · 2011
    20. The Harmonies Played by TGF-β in Stem Cell Biology Cell Stem Cell · 2012 · 156 citations
    21. The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate Trends in cell biology · 2018 · 33 citations
    22. Controlling the stem cell niche: right time, right place, right strength BioEssays · 2005 · 29 citations
    23. Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling 2012 · 16 citations
    24. New substrates for stem cell control Philosophical Transactions of the Royal Society B · 2018 · 11 citations
    25. Development and Maintenance of Epidermal Stem Cells in Skin Adnexa International journal of molecular sciences · 2020 · 15 citations
    26. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    27. Molecular heterogeneity of quiescent melanocyte stem cells revealed by single‐cell RNA‐sequencing Pigment cell & melanoma research · 2024
    28. Epidermal keratinocyte stem cells: their maintenance and regulation Seminars in cell biology · 1992 · 25 citations
    29. Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation The EMBO Journal · 2016 · 29 citations
    30. Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors International Journal of Molecular Medicine · 2013 · 56 citations