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    Glossary Stem Cell Plasticity

    ability of stem cells to become different cell types

    Stem cell plasticity, also known as stem cell flexibility or adaptability, refers to the ability of stem cells to differentiate into a variety of cell types beyond their original lineage. For example, a stem cell from the bone marrow, which typically produces blood cells, might be able to transform into a nerve cell or a muscle cell under certain conditions. This characteristic is crucial for regenerative medicine and therapies aimed at repairing damaged tissues or treating diseases like alopecia, where hair follicle stem cells might be harnessed to regenerate hair.

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    1. Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging Frontiers in Cell and Developmental Biology · 2022 · 7 citations
    2. Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices Science · 2024 · 1 citations
    3. Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice Nature · 2015 · 321 citations
    4. Stretching the limits: from homeostasis to stem cell plasticity in wound healing and cancer Nature Reviews Genetics · 2018 · 124 citations
    5. Stem cell dynamics, migration and plasticity during wound healing Nature Cell Biology · 2018 · 211 citations
    6. Lineage potential, plasticity and environmental reprogramming of epithelial stem/progenitor cells Biochemical Society Transactions · 2014 · 4 citations
    7. Neural Potential of a Stem Cell Population in the Hair Follicle Cell Cycle · 2007 · 80 citations
    8. Switching roles: the functional plasticity of adult tissue stem cells The EMBO Journal · 2015 · 87 citations
    9. The in vitro plasticity of hair follicle dermal and mesenchymal stem cells Durham e-Theses (Durham University) · 2008
    10. From neural crest cells to melanocytes: cellular plasticity during development and beyond Cellular and Molecular Life Sciences · 2019 · 66 citations
    11. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015 · 129 citations
    12. Diverse mechanisms for endogenous regeneration and repair in mammalian organs Nature · 2018 · 172 citations
    13. Somatic stem cell heterogeneity: diversity in the blood, skin and intestinal stem cell compartments Nature Reviews Molecular Cell Biology · 2015 · 137 citations
    14. Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin Cold Spring Harbor Perspectives in Medicine · 2014 · 96 citations
    15. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells Nature · 2010 · 116 citations
    16. Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair Nature Communications · 2026
    17. Sic Transit Gloria: Farewell to the Epidermal Transit Amplifying Cell? Cell Stem Cell · 2007 · 153 citations
    18. Dermal niche signaling and epidermal stem cells Advances in stem cells and their niches · 2019
    19. Targeting Adult Mesenchymal Stem Cells Plasticity for Tissue Regeneration Stem Cells International · 2017 · 3 citations
    20. Fibroblasts and wound healing: an update Regenerative Medicine · 2018 · 146 citations
    21. Epithelial stem cells and implications for wound repair Seminars in Cell & Developmental Biology · 2012 · 156 citations
    22. Characterization of new stem/progenitor cells in skin appendages University of Southern California Digital Library · 2013
    23. Tracking adult stem cells EMBO Reports · 2011 · 180 citations
    24. Single-Cell Transcriptomics to Map Cellular Heterogeneity in Tissue Regeneration Models Drug Discovery and Molecular Docking (DDMD) · 2025
    25. Concise Review: The Plasticity of Stem Cell Niches: A General Property Behind Tissue Homeostasis and Repair Stem Cells · 2013 · 50 citations
    26. Stem cell plasticity enables hair regeneration following Lgr5+ cell loss Nature Cell Biology · 2017 · 56 citations
    27. Hair follicle stem cell cultures reveal self‐organizing plasticity of stem cells and their progeny The EMBO Journal · 2016 · 61 citations
    28. Signaling in the stem cell niche: regulating cell fate, function and plasticity Development · 2018 · 139 citations
    29. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices Cell · 2017 · 214 citations
    30. Nanoscale microenvironment engineering for expanding human hair follicle stem cell and revealing their plasticity Journal of Nanobiotechnology · 2021 · 15 citations