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210-240 / 1000+ resultsresearch A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch
In this study, researchers developed a nanocomposite microneedle patch containing copper/zinc dual-doped silica nanoparticles, which release substances to promote hair follicle regeneration by targeting various pathophysiological aspects of androgenic alopecia, presenting an effective anti-hair loss treatment strategy.
research MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5
This study found that miR-148a plays a significant role in regulating skin homeostasis and hair follicle cycling, influencing stem cell activity and development in mice.
research Photoprotective Effect of the Hydroalcoholic Extract from Red and Black Peruvian Varieties of <i>Phaseolus vulgaris</i> L.
This study found that a 5% gel with hydroalcoholic extract from black pop bean integument may have a photoprotective effect in mice exposed to UV-C radiation.
research From Waste to Beauty: Agri-Food By-Products as Sources of Antioxidant Compounds for Cosmeceutical Applications
This review identifies agri-food by-products as promising sources of antioxidant compounds for cosmeceutical applications, examining their potential for skin, oral, and hair care, while noting the need for further research on safety and clinical efficacy.
research Iron Deficiency-Induced Hair Loss Is Associated with ROS-Mediated Disruption of Wnt/β-Catenin Signaling
This study in mice found that maternal iron deficiency led to hair loss and growth abnormalities in offspring due to increased oxidative stress and disrupted signaling pathways, but postnatal iron supplementation was able to reverse these effects.
research Coreopsis tinctoria Nutt. As a New Raw Material for Natural Hair Coloration: Discovering the Dyeing Potential of Chalcones
This study developed a natural hair dye using Coreopsis tinctoria Nutt. extract, finding that it produced yellow to dark brown colors depending on the treatment, with ferrous lactate enhancing dye performance and color stability after washing.
research H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers
This study observed that the loss of H3K9me3, via the ablation of Suv39h1, Suv39h2, and Setdb1 in embryonic mouse epidermis, disrupts skin development processes such as keratinocyte differentiation and hair follicle formation, highlighting H3K9me3's crucial role in epidermal morphogenesis.
research The Genus Astragalus Species as an Emerging Source of Bioactive Phytochemicals: A Review of Dermatological and Cosmetic Applications
In this review, several studies on Astragalus species, particularly Astragalus membranaceus, highlight their skin rejuvenating, photoprotective, antimicrobial, and wound-healing properties, though the authors note limitations due to reliance on non-human studies and short trial durations.
research Enhancing Cancer Therapy with Hyperthermia: Synergistic Effects with Natural Compounds and Conventional Treatments
This review discusses the potential benefits of hyperthermia in cancer therapy, combined with natural compounds, to enhance treatment efficacy and reports no new clinical results.
research Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives
This narrative review highlights that declining testosterone levels are a complex public health issue potentially influenced by modifiable lifestyle factors and environmental stressors, suggesting integrated strategies may be needed to address the trend's impacts on health.
research Interdisciplinarity traditional Chinese medicine microneedles in skin disease treatment: Recent advances and challenges
This review highlights the potential of microneedle technology in traditional Chinese medicine as a promising transdermal delivery system for skin diseases, showcasing improved efficacy and reduced side effects of TCM ingredients while discussing the challenges of its clinical application.
research Therapeutic potential of extracellular vesicles derived from Platycladus Orientalis leaf in treating anxiety, depression, and insomnia
This study suggests that P. orientalis leaf-derived EVs could offer anxiolytic, antidepressant, and sleep-inducing benefits by affecting neurotransmitter levels and reducing inflammation, particularly when administered intranasally.
research Effect of Supplemental Trace Mineral Source on Haircoat and Hair Loss in Adult Cats
In this study, cats fed trace minerals complexed with lysine and glutamic acid displayed temporary improvements in hair loss and dander scores at 45 days, compared to those receiving inorganic trace minerals, although no differences were seen by day 90.
research Emerging biomedical engineering strategies for hair follicle regeneration
This review summarizes advancements in biomedical engineering for hair follicle regeneration, highlighting strategies like cell transplantation and tissue engineering to reconstruct hair follicles, and discusses both their technical limitations and potential future innovations in regenerative medicine.
research The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury
This study found that dietary serine levels influence hair follicle stem cells' ability to balance hair regeneration and wound repair, offering insights for potential interventions to accelerate wound healing.
research Focused Review on Metal Nanoparticles in Hair Regeneration and Alopecia: Insights into Mechanisms, Assessment Techniques, Toxicity, Regulatory and Intellectual Property Perspectives
This review explores the potential of metal nanoparticles as innovative treatments for alopecia, highlighting their effectiveness in promoting hair regrowth, enhancing drug delivery, and modulating gene expression while also assessing the related experimental methodologies and regulatory considerations.
research Wnt signaling modulates mechanotransduction in the epidermis to drive hair follicle regeneration
This study demonstrates that Wnt signaling plays a crucial mechanoregulatory role in skin regeneration by influencing cellular responses to substrate rigidity, which promotes hair follicle regeneration in the wound-induced hair neogenesis model.
research The involvement of Elf5 in regulating keratinocyte proliferation and differentiation processes in skin
This study identified the transcription factor Elf5 as a novel regulator of keratinocyte proliferation and differentiation in skin, with expression elevated in stem/progenitor cell populations, suggesting its potential role in determining cell fate during skin and hair development.
research The Genomic Variation in Textured Hair: Implications in Developing a Holistic Hair Care Routine
This review highlights the lack of research on Afro-textured hair, emphasizing the need for better understanding of its genetic traits and molecular structure to develop more effective hair care solutions.
research Mesoterapia. Una revisión crítica
This study clarifies the fundamental aspects of intradermotherapy or mesotherapy, tracing its historical development and highlighting its benefits as well as the negative consequences of improper use, specifically addressing its decline due to severe side effects from treatment errors.
research Hydrogel Composites for Multifunctional Biomedical Applications
This review details how hydrogel composites play crucial roles in regenerative medicine, tissue engineering, and drug delivery systems, highlighting innovations in these applications and addressing challenges like bioactivity, biomechanical compatibility, and controlled drug release.
research Overview of popular cosmeceuticals in dermatology
This source reviews popular cosmeceutical ingredients for skin care, noting that while they are popular among consumers for anti-aging benefits, many lack robust clinical evidence for their efficacy and safety, as they are not regulated by the FDA.
research Apoptotic dysregulation mediates stem cell competition and tissue regeneration
This study reported that depleting the pro-apoptotic protein Bax in hair follicle stem cells enables these cells to kill nearby viable cells by sequestering TNFα, which increases the stem cell pool and accelerates tissue regeneration, suggesting potential implications for therapies targeting tissue repair and cancer.
research An Updated Etiology of Hair Loss and the New Cosmeceutical Paradigm in Therapy: Clearing ‘the Big Eight Strikes’
This review concluded that the efficacy of cosmeceutical hair serums for addressing hair loss lies in their use of bioactive peptides and plant compounds, like flavonoids and sterols, that target eight key contributing factors identified in hair loss conditions.
research Efficacy and Tolerability of a Topical Gel Containing Mimicking Growth Factors Oligopeptides, Caffeine, Taurine and an Iron-Chelating Complex in Subjects with Androgenetic Alopecia Treated with Topical Minoxidil or Oral Finasteride: a Prospective, 6-Month, Randomized, Assessor-Blinded, 4-Arm, Parallel Group Study
In this study, the addition of a topical gel containing growth-factor mimicking oligopeptides and other ingredients showed improved efficacy in subjects with androgenic alopecia using minoxidil or finasteride compared to drug treatment alone.
research Sodium Valproate in Treatment of Epilepsy
This study found that sodium valproate effectively stopped or reduced seizures in patients with various types of epilepsy, with best results in absence and myoclonic seizures, though it caused temporary hair loss in some cases.
research Effects of sodium valproate in 100 children with special reference to weight.
This study found that while sodium valproate improved seizure control in children with epilepsy, it often led to increased weight gain, with no severe side effects like liver disease or pancreatitis reported.
research Sodium chloride reduces growth and cytosolic calcium, but does not affect cytosolic pH, in root hairs of Arabidopsis thaliana L.
This study found that salinity stress in Arabidopsis thaliana root hairs may inhibit hair extension through changes in the tip-focused Ca(2+) gradient, while cytosolic pH remains unaffected.
research Sodium valproate and thrombocytopenia.
This case report observed that a child developed thrombocytopenia, characterized by a low platelet count and prolonged bleeding time, while on sodium valproate monotherapy for seizures.