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    Glossary Skin Models

    laboratory-created systems mimicking human skin for research purposes

    Skin models are laboratory-created systems that mimic the structure and function of human skin. These models are used for research and testing purposes, such as studying skin diseases, testing cosmetics, and understanding wound healing, without the need for human or animal subjects. They can be made from biological materials or engineered tissues, providing a controlled environment to observe skin behavior and responses.

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    1. Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion Lab on a Chip · 2013 · 208 citations
    2. Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles Burns & Trauma · 2021 · 65 citations
    3. A Composite Model for the Transport of Hydrophilic and Lipophilic Compounds Across the Skin: Steady-State Behavior Journal of pharmaceutical sciences · 2018 · 32 citations
    4. Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis Biomedicines · 2020 · 26 citations
    5. Effects of non-ablative fractional erbium glass laser treatment on gene regulation in human three-dimensional skin models Lasers in Medical Science · 2016 · 24 citations
    6. Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model <i>in vitro</i>: implications for regenerative therapy of canine epidermis Veterinary dermatology · 2013 · 11 citations
    7. Optimization of Gelatin and Crosslinker Concentrations in a Gelatin/Alginate-Based Bioink with Potential Applications in a Simplified Skin Model Molecules · 2025 · 8 citations
    8. A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin Biofabrication · 2024 · 6 citations
    9. Microscopy‐guided laser ablation for the creation of complex skin models with folliculoid appendages Bioengineering & translational medicine · 2020 · 5 citations
    10. Type 2 Cytokine–Dependent Skin Barrier Regulation in Personalized 2-Dimensional and 3-Dimensional Skin Models of Atopic Dermatitis: A Pilot Study JID Innovations · 2024 · 2 citations
    11. Folate bioavailability in reconstructed skin models and effects of folate in a monolayer wound healing assay. Approaches on topic application bioRxiv (Cold Spring Harbor Laboratory) · 2021
    12. Exploring the Efficacy and Potential Mechanisms of Topical Periplaneta americana (L.) Extract in Treating Androgenetic Alopecia in a Mouse Model: A Systems Pharmacology and Skin Microbiome Analysis Biology · 2025
    13. In Vitro Skin Models for Pigmentary Disorders: From Reconstructed Tissues to Skin-on-a-Chip Platforms Regenerative Biomaterials · 2026
    14. Skin organoids: A new human model for developmental and translational research Experimental Dermatology · 2021 · 31 citations
    15. A model system for long-term serum-free suspension organ culture of human fetal tissues: experiments on digits and skin from multiple body regions Cell and Tissue Research · 1997 · 17 citations
    16. A Porcine Model for the Development and Testing of Preoperative Skin Preparations Microorganisms · 2022 · 4 citations
    17. 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration Wound Repair and Regeneration · 2025 · 3 citations
    18. Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models Archives of Toxicology · 2018 · 38 citations
    19. Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin Frontiers in Medicine · 2024 · 8 citations
    20. An open-access data set of pig skin anatomy and physiology for modelling purposes Database · 2022 · 6 citations
    21. 685 Modelling intrinsic and extrinsic cellular senescence in vitro with complex bioengineered human skin constructs Journal of Investigative Dermatology · 2024
    22. Modeling of solar UV-induced photodamage on the hair follicles in human skin organoids Journal of tissue engineering · 2024
    23. 1344 Novel human 3D skin model for skin aging research Journal of Investigative Dermatology · 2023
    24. 591 A New 3D Skin Model Containing Autologous Immune Cells Reconstructed by Tissue Engineering Journal of Investigative Dermatology · 2019
    25. Modeling aging in a culture dish: towards the development of more sophisticated in vitro models of human skin aging Ageing Research Reviews · 2026
    26. An Animal Model of Trichloroethylene-Induced Skin Sensitization in BALB/c Mice International journal of toxicology · 2015 · 36 citations
    27. The Model of an Ischemic Non-Healing Wound: Regeneration after Transplantation of a Living Skin Equivalent Sovremennye tehnologii v medicine · 2023
    28. In-Silico Modelling of Transdermal Delivery of Macromolecule Drugs Assisted by a Skin Stretching Hypobaric Device Pharmaceutical research · 2022 · 1 citations
    29. Neonatal murine skin-derived cells transplanted using a mini-chamber model produce robust and normal hair Journal of Tissue Engineering and Regenerative Medicine · 2013 · 9 citations
    30. Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis Nature Communications · 2026