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    Glossary Skin Barrier Formation

    process by which skin's outer layer develops protective functions

    Skin barrier formation refers to the process by which the outermost layer of the skin, known as the stratum corneum, develops to protect the body from environmental threats like pathogens, chemicals, and physical injuries. This barrier is composed of tightly packed dead skin cells and lipids, which work together to prevent water loss and maintain hydration, ensuring the skin remains healthy and functional.

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    Research 30 of 1000+

    1. Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia American Journal of Pathology · 2007 · 67 citations
    2. 874 Chromatin architectural protein CTCF controls epidermal barrier formation, hair follicle fate maintenance and suppresses inflammatory responses in the skin epithelium Journal of Investigative Dermatology · 2017
    3. 1397 LSD1 is critical for epidermal development and skin barrier formation Journal of Investigative Dermatology · 2023
    4. 177 The Striatin-Interacting Phosphatase And Kinases complex is important for skin epidermal differentiation and barrier formation 2022
    5. Faculty Opinions recommendation of Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2007
    6. Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis American Journal Of Pathology · 2006 · 100 citations
    7. Mutations in AEC syndrome skin reveal a role for p63 in basement membrane adhesion, skin barrier integrity and hair follicle biology British Journal of Dermatology · 2012 · 33 citations
    8. Deimination in epidermal barrier and hair formation Philosophical transactions - Royal Society. Biological sciences · 2023 · 2 citations
    9. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation Journal of Allergy and Clinical Immunology · 2019 · 34 citations
    10. 647 Alternative splicing factor Esrp1 controls homeostasis of skins by regulating barrier formation and function 2018
    11. Nanotechnological reprogramming of the pathological skin microenvironment in scar formation and atopic dermatitis Journal of Pharmaceutical Investigation · 2026
    12. The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function) Free Radical Biology and Medicine · 2015
    13. The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling Frontiers in Cell and Developmental Biology · 2022 · 35 citations
    14. 169 TEDAR, a skin-specific long non-coding RNA, orchestrates the late epidermal differentiation program in the human epidermis Journal of Investigative Dermatology · 2025
    15. The Therapeutic Role of ADSC-EVs in Skin Regeneration Frontiers in Medicine · 2022 · 7 citations
    16. SKIN SURFACE CHEMISTRY AS A DIAGNOSTIC TOOL FOR SKIN DISEASES International Journal of Research in Medical Sciences & Technology · 2021
    17. ZNF750 safeguards upper hair follicle homeostasis to prevent inflammatory skin disease Journal of Investigative Dermatology · 2026
    18. Formation of the cornified envelope Experimental dermatology · 2005 · 3 citations
    19. The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity Stem cell biology and regenerative medicine · 2018
    20. Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages Drug Design Development and Therapy · 2020 · 130 citations
    21. Redox-directed interventions targeting skin photodamage Free Radical Biology and Medicine · 2015
    22. Lysine Carboxymethyl Cysteinate (LCC) Protects the Epidermis from UVB-Induced Barrier Damage Through the Activation of Autophagy Biology · 2026
    23. p63 in skin homeostasis and disease: molecular mechanisms and therapeutic potentials Cell Death Discovery · 2026
    24. Natural bioenhancers for dermal delivery: Mechanisms, formulation design and cosmeceutical applications Journal of Drug Delivery Science and Technology · 2026
    25. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    26. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity The Journal of Cell Biology · 2015 · 98 citations
    27. 875 A novel animal model of Desmoglein 1 (Dsg1) deficiency reveals an essential role for Dsg1 in epidermal barrier formation Journal of Investigative Dermatology · 2018
    28. Spatial transcriptomics of a giant pilomatricoma Journal of cutaneous pathology · 2023 · 1 citations
    29. H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers Nature Communications · 2026
    30. Dysregulation of Grainyhead-like 3 expression causes widespread developmental defects Research Square (Research Square) · 2021