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    Glossary Sex Hormone-Binding Globulin

    protein that regulates sex hormones' availability in the bloodstream

    Sex Hormone-Binding Globulin (SHBG) is a protein produced by the liver that binds to sex hormones, such as testosterone and estrogen, in the bloodstream. By binding to these hormones, SHBG regulates their bioavailability and activity in the body, influencing various physiological processes, including hair growth and reproductive functions.

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    1. Sex hormone binding globulin - an important biomarker for predicting PCOS risk: A systematic review and meta-analysis Systems Biology in Reproductive Medicine · 2017 · 91 citations
    2. Low sex hormone-binding globulin is associated with low high-density lipoprotein cholesterol and metabolic syndrome in women with PCOS Human Reproduction · 2006 · 71 citations
    3. Sex Hormone-Binding Globulin (SHBG) as an Early Biomarker and Therapeutic Target in Polycystic Ovary Syndrome International Journal of Molecular Sciences · 2020 · 58 citations
    4. EFFECTS OF A LOW‐DOSE DESOGESTREL‐ETHINYLESTRADIOL COMBINATION ON HIRSUTISM, ANDROGENS AND SEX HORMONE BINDING GLOBULIN IN WOMEN WITH A POLYCYSTIC OVARY SYNDROME Acta obstetricia et gynecologica Scandinavica · 1985 · 53 citations
    5. Low sex-hormone binding globulin levels in young women with diffuse hair loss British Journal of Dermatology · 1982 · 40 citations
    6. Common variants in the sex hormone-binding globulin gene (SHBG) and polycystic ovary syndrome (PCOS) in Mediterranean women Human Reproduction · 2012 · 39 citations
    7. Sex hormone–binding globulin and risk of hyperglycemia in patients with androgenetic alopecia Journal of The American Academy of Dermatology · 2011 · 36 citations
    8. Unchanged androgen-binding properties of sex hormone-binding globulin in male patients with liver cirrhosis Clinical chemistry and laboratory medicine · 2006 · 29 citations
    9. Sex hormone-binding globulin and saliva testosterone levels in men with androgenetic alopecia British Journal of Dermatology · 1983 · 29 citations
    10. Common Variants in the Sex Hormone-Binding Globulin (SHBG) Gene Influence SHBG Levels in Women with Polycystic Ovary Syndrome Annals of Nutrition and Metabolism · 2015 · 24 citations
    11. Efficacy of metformin therapy in adolescent girls with androgen excess: relation to sex hormone–binding globulin and androgen receptor polymorphisms Fertility and sterility · 2010 · 15 citations
    12. Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program BMJ Open Diabetes Research & Care · 2020 · 13 citations
    13. Female androgenic alopecia. The 3 alpha,17 beta-androstanediol glucuronide/sex hormone binding globulin ratio as a possible marker for female pattern baldness Archives of Dermatology · 1986 · 13 citations
    14. The injectable contraceptives depot medroxyprogesterone acetate and norethisterone enanthate substantially and differentially decrease testosterone and sex hormone binding globulin levels: A secondary study from the WHICH randomized clinical trial PLoS ONE · 2024 · 4 citations
    15. Testosterone, sex hormone-binding globulin and dehydroepiandrosterone levels and cervical length of Egyptian women with a history of recurrent miscarriages, polycystic ovary syndrome and without the conditions at three stages of pregnancy Journal of Obstetrics and Gynaecology · 2023 · 1 citations
    16. Sex Hormone-Binding Globulin as more than a Biomarker of Metabolic Diseases and Reproductive Disorders: What Physicians Should Know? Journal of Biomedical Research & Environmental Sciences · 2024
    17. Effects of depot medroxyprogesterone acetate, the copper IUD and the levonorgestrel implant on testosterone, sex hormone binding globulin and free testosterone levels: ancillary study of the ECHO randomized clinical trial BMC women's health · 2024
    18. [Usefulness and limitations of the evaluation of sex-hormone-binding globulin in women with a female pattern of androgen-induced baldness]. PubMed · 1989
    19. Sex hormone-binding globulin (SHBG) and androgen levels in women with androgenetic alopecia European journal of endocrinology · 1987
    20. Serum testosterone and sex hormone binding globulin levels in women with androgenetic alopecia. PubMed · 1986
    21. Levonorgestrel effects on serum androgens, sex hormone–binding globulin levels, hair shaft diameter, and sexual function Fertility and Sterility · 2009 · 20 citations
    22. Emerging Roles of Steroid-binding Globulins Hormone and metabolic research · 2006 · 41 citations
    23. Sex steroid hormones are associated with mortality in COVID-19 patients Medicine · 2021 · 26 citations
    24. Does Cyclosporin A Influence Sex Hormone Level? Experimental and Clinical Endocrinology & Diabetes · 2009 · 20 citations
    25. The influence of cyclosporine A therapy on sex hormone levels in pre- and post-menopausal women with primary biliary cirrhosis Journal of hepatology · 1994 · 4 citations
    26. Associations between genetically predicted sex and growth hormones and facial aging in the UK Biobank: a two−sample Mendelian randomization study Frontiers in endocrinology · 2023 · 1 citations
    27. Changes of sex hormone levels in male acne patients with normal serum testosterone and effect of antiandrogen therapy Academic Journal of Second Military Medical University · 2009
    28. Sex differences in the hypothalamic–pituitary–adrenal axis’ response to stress: an important role for gonadal hormones Neuropsychopharmacology · 2019 · 197 citations
    29. Receiver operating characteristic analysis of the performance of basal serum hormone profiles for the diagnosis of polycystic ovary syndrome in epidemiological studies European journal of endocrinology · 2001 · 66 citations
    30. Metformin influence on hormone levels at birth, in PCOS mothers and their newborns Human reproduction · 2009 · 35 citations