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GlossarySerine

amino acid involved in protein synthesis and metabolism

Serine is an amino acid that plays a crucial role in the body, particularly in the synthesis of proteins and other important molecules like phospholipids and neurotransmitters. It is also involved in the metabolism of fats and fatty acids, and is essential for the proper functioning of the central nervous system and immune system.

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research Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 in a Growth- and Stress-Dependent Fashion

30 citations, December 2011 in “Journal of biological chemistry/The Journal of biological chemistry”

Keratin 17 is modified by RSK1 in response to growth and stress, affecting skin growth and stress response.

Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators in Differentiation, Proliferation, and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study

research Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators in Differentiation, Proliferation, and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study

January 2023 in “Frontiers in bioscience”

Artemis protein may help control hair growth and health by influencing cell processes.

research Delayed Hair Cycle in Mnd2 Mutant Mice Lacking HtrA2 Serine Protease Activity

December 2022 in “Biochemical and Biophysical Research Communications”

HtrA2 activity is crucial for normal hair growth by regulating fat cell development.

Male Balding as a Major Risk Factor for Severe COVID-19: A Possible Role for Targeting Androgens and Transmembrane Protease Serine 2 to Protect Vulnerable Individuals

research Male Balding as a Major Risk Factor for Severe COVID-19: A Possible Role for Targeting Androgens and Transmembrane Protease Serine 2 to Protect Vulnerable Individuals

6 citations, September 2020 in “Journal of The American Academy of Dermatology”

Severe male balding may increase the risk of serious COVID-19, and treatments that reduce androgens or block a specific enzyme might help protect these individuals.

research Promotion of Hair Growth by Applying Sulfur Amino Acids and Other Compounds to the Skin

January 1974 in “Nippon Nōgei Kagakukaishi/Nihon Nougei Kagakkaishi”

Applying L-methionine and L-serine to the skin promotes the most hair growth.

research Characterization of Human KAP24.1, A Cuticular Hair Keratin-Associated Protein with Unusual Amino Acid Composition and Repeat Structure

51 citations, January 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists discovered a unique hair protein, KAP24.1, with a special structure, found only in the upper part of hair cuticles.

Functional Identification of the Phosphorylation Sites of Arabidopsis PIN-FORMED3 for Its Subcellular Localization and Biological Role

research Functional Identification of the Phosphorylation Sites of Arabidopsis PIN-FORMED3 for Its Subcellular Localization and Biological Role

47 citations, April 2012 in “The Plant Journal”

Phosphorylation of certain parts of the PIN3 protein is crucial for its role in plant root growth and response to gravity.

research Soymilk Reduces Hair Growth And Hair Follicle Dimensions

23 citations, December 2001 in “Experimental dermatology”

Soymilk can slow hair growth and make hair thinner.

research A Novel Mutation in ST14 at a Functionally Significant Amino Acid Residue Expands the Spectrum of Ichthyosis-Hypotrichosis Syndrome

11 citations, December 2017 in “Orphanet Journal of Rare Diseases”

A new mutation in the ST14 gene broadens the understanding of ichthyosis-hypotrichosis syndrome.

research Protease Activity, Localization, and Inhibition in the Human Hair Follicle

11 citations, August 2013 in “International Journal of Cosmetic Science”

The study suggests that a new protease inhibitor can make hair harder to pull out, potentially reducing hair loss.

research Identification of 736T>A Mutation of Lipase H in Japanese Siblings with Autosomal Recessive Woolly Hair

7 citations, February 2011 in “Journal of dermatology”

The 736T>A mutation in the LIPH gene is common in Japanese people with autosomal recessive woolly hair.

research Protein Kinase Akt2/PKBβ Is Involved in Blastomere Proliferation of Preimplantation Mouse Embryos

7 citations, September 2019 in “Journal of Cellular Physiology”

Akt2 protein is essential for normal cell division in early mouse embryos.

research Human Hair Proteins as Natural Reactive Oxygen Species Scavengers for In Vitro Applications

4 citations, November 2022 in “Journal of biomedical materials research. Part B, Applied biomaterials”

Human hair proteins, especially keratins, can protect cells from oxidative stress in lab settings.

research Investigating the Relationship Between the Hair Fiber Proteome and Hair Quality

2 citations, September 2004 in “International Journal of Cosmetic Science”

Hair quality is genetically determined and linked to its composition and strength.

research Enzymatic Crosslinking of Amino Acids Improves the Repair Effect of Keratin on Hair Fiber

May 2023 in “Polymers”

Using enzymes to link proteins makes hair repair treatments more effective and long-lasting.

research Are STK11 Polymorphisms a Predictor of the Response to Metformin in Polycystic Ovarian Syndrome?

June 2022 in “Biomedical reports”

STK11 gene variations do not predict how well metformin will work for PCOS, but may affect hair loss and excess hair growth.

research Novel Biallelic RIPK4 Mutations Cause Ectodermal Dysplasia with Cutaneous Syndactyly

September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

New RIPK4 gene mutations were found to cause a type of skin and limb birth defect.

research A 20-Year Retrospective Clinicopathologic Study on Melanoma in Singapore

August 2019 in “Journal of The American Academy of Dermatology”

Bleach baths with 0.005% hypochlorite help manage atopic dermatitis by affecting skin cells and reducing itchiness.

research PLAU and SerpinB2 Role in Apoptosis in Leprosy

May 2017 in “Journal of The American Academy of Dermatology”

PLAU and SerpinB2 affect cell death differently in various forms of leprosy and could be targets for new treatments.

Bamboo Hair Syndrome or Netherton Syndrome: A Case Report

research Identification of Novel Mutation in the HR Gene Responsible for Atrichia with Papular Lesions in a Pakistani Family

5 citations, September 2013 in “The Journal of Dermatology”

Researchers found a new mutation in the HR gene causing hair loss and skin bumps in a Pakistani family.

research Delayed-Onset Pachyonychia Congenita Caused by a Novel Mutation in the V2 Domain of Keratin 6B

4 citations, December 2013 in “The Journal of Dermatology”

A new mutation in the K6b gene caused a girl's late-appearing nail condition.

research The CAP1/Prss8 Catalytic Triad Is Not Involved in PAR2 Activation and Protease Nexin-1 (PN-1) Inhibition

14 citations, August 2014 in “The FASEB Journal”

CAP1/Prss8 does not activate PAR2 or inhibit PN-1.

research Involvement of RIPK1 in Alopecia Areata

September 2024

RIPK1 inhibitors might help prevent alopecia areata.