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    Glossary Senescent Cells

    cells that have stopped dividing and contribute to aging

    Senescent cells are cells that have stopped dividing and entered a state of permanent growth arrest without dying. They accumulate with age and can contribute to aging and age-related diseases by secreting harmful substances that can damage surrounding tissues.

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    1. Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL Nature communications · 2016 · 665 citations
    2. Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy Cell death and differentiation · 2015 · 56 citations
    3. Honokiol protects skin cells against inflammation, collagenolysis, apoptosis, and senescence caused by cigarette smoke damage International Journal of Dermatology · 2017 · 20 citations
    4. Single‐cell transcriptomics reveals a senescence‐associated IL ‐6/ CCR6 axis driving radiodermatitis EMBO molecular medicine · 2022 · 9 citations
    5. Imbalanced redox dynamics induce fibroblast senescence leading to impaired stem cell pools and skin aging Free Radical Biology and Medicine · 2025 · 7 citations
    6. Application of mesenchymal stem cells for anti-senescence and clinical challenges Stem cell research & therapy · 2023 · 1 citations
    7. Restoration of hair follicle inductive properties by depletion of senescent cells Aging Cell · 2024
    8. Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy Redox biology · 2023
    9. 487 Exploring ribosomal RNA modifications and corresponding snoRNAs in human skin cell senescence Journal of Investigative Dermatology · 2024
    10. 559 Induction of tissue-specific premature stem cell aging promotes senescence-like phenotypes in remote multiple organs Journal of Investigative Dermatology · 2022
    11. 1447 Anti-senescence effect of extracellular vesicle from hyaluronic acid primed induced mesenchymal stem cells on aged human dermal fibroblast Journal of Investigative Dermatology · 2023
    12. Secreted Frizzled‐Related Protein 2 ( SFRP2 ) Induces Follistatin‐Like 1 ( FSTL1 ) to Regulate Dihydrotestosterone ( DHT )‐Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence Aging Cell · 2026
    13. The Yin–Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease Biocell · 2025
    14. PBX1 Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence and Apoptosis by Alleviating Reactive Oxygen Species-Mediated DNA Damage Instead of Enhancing DNA Damage Repair Frontiers in Cell and Developmental Biology · 2021 · 9 citations
    15. Dermal papilla cells-conditioned medium attenuates oxidative stress-induced senescence via ferroptosis inhibition Scientific Reports · 2025
    16. Camellia japonica seed extract promotes hair growth by preventing dermal papilla cell senescence and activating hair follicle stem cells Biotechnology and Bioprocess Engineering · 2025
    17. LncRNA H19 inhibited dermal papilla cell senescence process through miR-29a by targeting Wnt/β-catenin signaling pathway Archives of Dermatological Research · 2025
    18. Oxidative Stress–Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia Journal of Investigative Dermatology · 2015 · 93 citations
    19. Embryonic NIPP1 depletion in keratinocytes triggers a cell-cycle arrest and premature senescence in adult mice Journal of Investigative Dermatology · 2024
    20. Stress-induced senescence of dermal papilla cells restored by synthesized ceramide 2017
    21. Premature Senescence of Balding Dermal Papilla Cells In Vitro Is Associated with p16INK4a Expression Journal of Investigative Dermatology · 2007 · 141 citations
    22. Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage PLOS ONE · 2013 · 30 citations
    23. Implication of microRNA regulation in para-phenylenediamine-induced cell death and senescence in normal human hair dermal papilla cells Molecular Medicine Reports · 2015 · 8 citations
    24. 090 Reactive lipids from the secretome of senescent fibroblasts modify the extracellular matrix with functional consequences for resident cells Journal of Investigative Dermatology · 2024
    25. 1380 Ganoderma lucidum extract attenuates Corticotropin-Releasing Factor (CRF)-induced cellular senescence in human hair follicular cells Journal of Investigative Dermatology · 2023
    26. 277 Stress-induced senescence of dermal papilla cells restored by synthesized ceramide Journal of Investigative Dermatology · 2017
    27. Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells Current Issues in Molecular Biology · 2021 · 13 citations
    28. ACOD1 deficiency promotes DDX1 methylation–mediated mitochondrial dysfunction and dermal papilla cell senescence in androgenetic alopecia BMC Medicine · 2026
    29. Oxidative Stress and Hormone-regulated Dermal Papilla Cell-targeted Nanomodulators: Reverse Cellular Senescence for Androgenetic Alopecia Therapy Biomaterials Research · 2026
    30. Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells iScience · 2024