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    Did you mean Selective Estrogen Receptor Modulators?
    Glossary Selective Estrogen Receptor Modulators

    modulate estrogen effects in different tissues selectively

    Selective Estrogen Receptor Modulators (SERMs) are a class of compounds that act on the estrogen receptor. They can either block or activate estrogen's effects in different tissues, depending on the specific SERM and the tissue type. For example, they might block estrogen's action in breast tissue to reduce the risk of breast cancer, while activating it in bone tissue to help maintain bone density.

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    Research 30 of 1000+

    1. Family planning 2011: better use of existing methods, new strategies and more informed choices for female contraception Human Reproduction Update · 2012 · 11 citations
    2. Relating neurosteroid modulation of inhibitory neurotransmission to behaviour Journal of Neuroendocrinology · 2021 · 18 citations
    3. Chapter 17. Selective androgen receptor modulators (SARMs) Annual Reports in Medicinal Chemistry · 2001 · 18 citations
    4. Effect of estrogens on skin aging and the potential role of selective estrogen receptor modulators Climacteric · 2007 · 67 citations
    5. Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling PloS one · 2014 · 56 citations
    6. Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands 2009 · 36 citations
    7. Androgen receptor modulators: a review of recent patents and reports (2012-2018) Expert Opinion on Therapeutic Patents · 2019 · 23 citations
    8. Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus Journal of Endocrinology · 2019 · 19 citations
    9. <i>In Vitro</i>and<i>in Vivo</i>Structure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring Endocrinology · 2005 · 20 citations
    10. Recent discoveries and developments of androgen receptor based therapy for prostate cancer MedChemComm · 2015 · 17 citations
    11. Therapeutic Androgen Receptor Ligands Nuclear Receptor Signaling · 2003 · 16 citations
    12. Androgen Receptor Ligands: Agonists and Antagonists Elsevier eBooks · 2017 · 2 citations
    13. Menopause and aging, quality of life and sexuality Climacteric · 2007 · 55 citations
    14. Negative Impact of Testosterone Deficiency and 5α-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men Advances in Experimental Medicine and Biology · 2017 · 31 citations
    15. The role of estrogen in cutaneous ageing and repair Maturitas · 2017 · 158 citations
    16. Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats European Journal of Pharmacology · 2007 · 27 citations
    17. New approaches to the treatment of osteoporosis Current Opinion in Chemical Biology · 2000 · 28 citations
    18. Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor Neurobiology of Stress · 2019 · 40 citations
    19. Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women Obstetrics and gynecology international · 2011 · 19 citations
    20. Role of  -catenin in Epidermal Stem Cell Expansion, Lineage Selection, and Cancer Cold Spring Harbor Symposia on Quantitative Biology · 2008 · 61 citations
    21. The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta? Journal of Investigative Dermatology · 2006 · 65 citations
    22. The neurosteroidogenic enzyme 5α-reductase modulates the role of D1 dopamine receptors in rat sensorimotor gating Psychoneuroendocrinology · 2015 · 49 citations
    23. Progesterone Promotes Anti-Anxiety/Depressant-like Behavior and Trophic Actions of BDNF in the Hippocampus of Female Nuclear Progesterone Receptor, but Not 5α-Reductase, Knockout Mice International Journal of Molecular Sciences · 2025 · 4 citations
    24. Neurosteroid Synthesis-Mediated Regulation of GABA<sub>A</sub>Receptors: Relevance to the Ovarian Cycle and Stress Journal of Neuroscience · 2007 · 238 citations
    25. Neurosteroidogenesis Today: Novel Targets for Neuroactive Steroid Synthesis and Action and Their Relevance for Translational Research Journal of Neuroendocrinology · 2015 · 123 citations
    26. Steroid Hormones Elsevier eBooks · 2016 · 3 citations
    27. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    28. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004 · 180 citations
    29. PR-independent neurosteroid regulation of α2-GABA-A receptors in the hippocampus subfields Brain research · 2017 · 14 citations
    30. Kelulut Honey Regulates Sex Steroid Receptors in a Polycystic Ovary Syndrome Rat Model International Journal of Molecular Sciences · 2022 · 1 citations