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    Glossary Selective Androgen Receptor Modulators

    compounds that selectively target androgen receptors to promote muscle growth

    Selective Androgen Receptor Modulators (SARMs) are a class of compounds that bind to androgen receptors in the body, similar to anabolic steroids, but with more targeted effects. They are designed to selectively stimulate muscle and bone growth without significantly affecting other tissues, potentially offering therapeutic benefits for conditions like muscle wasting and osteoporosis with fewer side effects compared to traditional steroids.

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    1. The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial Journal of cachexia, sarcopenia and muscle · 2011 · 306 citations
    2. A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia Journal of Nutrition Health & Aging · 2013 · 211 citations
    3. Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators Journal of medicinal chemistry · 2004 · 129 citations
    4. Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling PloS one · 2014 · 56 citations
    5. Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands 2009 · 36 citations
    6. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells Biological and Pharmaceutical Bulletin · 2018 · 23 citations
    7. Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus Journal of Endocrinology · 2019 · 19 citations
    8. Chapter 17. Selective androgen receptor modulators (SARMs) Annual Reports in Medicinal Chemistry · 2001 · 18 citations
    9. Improving selective androgen receptor modulator discovery and preclinical evaluation Expert Opinion on Drug Discovery · 2009 · 11 citations
    10. Selective androgen receptor modulators: a critical appraisal Frontiers in Endocrinology · 2025 · 2 citations
    11. The Mechanisms of Anabolic Steroids, Selective Androgen Receptor Modulators and Myostatin Inhibitors 대한스포츠의학회지 · 2022 · 2 citations
    12. Abstract P5-09-21: Selective androgen receptor modulators (SARMs): Enobosarm as targeted therapy for the treatment of androgen receptor-positive breast cancer Cancer research · 2013 · 2 citations
    13. Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators Acta crystallographica · 2008 · 1 citations
    14. Hepatotoxicity Associated with Anabolic Androgenic Steroids and Selective Androgen Receptor Modulators: A Literature Review Medical Science · 2025
    15. Nonsteroidal Selective Androgen Receptors Modulators (SARMs): Designer Androgens with Flexible Structures Provide Clinical Promise Endocrinology · 2004 · 28 citations
    16. Nonsteroidal tissue selective androgen receptor modulators: a promising class of clinical candidates Expert opinion on therapeutic patents · 2005 · 38 citations
    17. Androgen receptor modulators: a review of recent patents and reports (2012-2018) Expert Opinion on Therapeutic Patents · 2019 · 23 citations
    18. A comprehensive investigation into the molecular mechanism responsible for selective androgen receptor (SARM) tissue-selectivity OhioLink ETD Center (Ohio Library and Information Network) · 2008
    19. The Effects of Estradiol, Androgens and the Selective Estrogen Modulators: Ospemifene, Raloxifene and Tamoxifen on Explant Cultures of Human Breast Tissue UTUPub (University of Turku) · 2013
    20. QSAR Analysis of a Series of Hydantoin‐based Androgen Receptor Modulators and Corresponding Binding Affinities Molecular Informatics · 2019
    21. The Androgen Receptor and Its Use in Biological Assays: Looking Toward Effect-Based Testing and Its Applications Journal of Analytical Toxicology · 2011 · 22 citations
    22. Androgen receptor: A promising therapeutic target in breast cancer Critical Reviews in Clinical Laboratory Sciences · 2019 · 21 citations
    23. <i>In Vitro</i>and<i>in Vivo</i>Structure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring Endocrinology · 2005 · 20 citations
    24. Recent discoveries and developments of androgen receptor based therapy for prostate cancer MedChemComm · 2015 · 17 citations
    25. Therapeutic Androgen Receptor Ligands Nuclear Receptor Signaling · 2003 · 16 citations
    26. Androgen Receptor Ligands: Agonists and Antagonists Elsevier eBooks · 2017 · 2 citations
    27. Probing androgen receptor co-factor selectivity profiles: a chemical tool to determine cross-talk between androgen receptor and β-catenin in vivo MedChemComm · 2013 · 1 citations
    28. Structural Characterization and Ligand Specific Protein Interactions of Androgen Receptor The Knowledge Bank (The Ohio State University) · 2008
    29. Myocyte Androgen Receptor Modulates Body Composition and Metabolic Parameters TSpace · 2010
    30. Intracrine and Myotrophic Roles of 5α-Reductase and Androgens Medicine and science in sports and exercise · 2011 · 35 citations