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    Glossary Sebocytes

    specialized cells in skin glands producing oily sebum

    Sebocytes are specialized cells found in the sebaceous glands of the skin. These cells produce and secrete sebum, an oily substance that helps to lubricate and protect the skin and hair. For professionals, it's important to note that sebocytes undergo a process called holocrine secretion, where the entire cell disintegrates to release its contents.

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    Research 30 of 881

    1. Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes Proceedings of the National Academy of Sciences · 2002 · 284 citations
    2. The Human Sebocyte Culture Model Provides New Insights into Development and Management of Seborrhoea and Acne Dermatology · 1998 · 198 citations
    3. Sebocytes are the Key Regulators of Androgen Homeostasis in Human Skin 2001 · 196 citations
    4. Sebocytes differentially express and secrete adipokines Experimental Dermatology · 2015 · 74 citations
    5. Short-Chain Fatty Acids from <i>Cutibacterium acnes</i> Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes 2019 · 70 citations
    6. “Sebocytes’ makeup” - Novel mechanisms and concepts in the physiology of the human sebaceous glands 2011 · 58 citations
    7. C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin PloS one · 2010 · 48 citations
    8. Influence of substance-P on cultured sebocytes Archives of Dermatological Research · 2008 · 46 citations
    9. Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone Skin Pharmacology and Physiology · 1994 · 40 citations
    10. Topical ALA-Photodynamic Therapy for Acne Can Induce Apoptosis of Sebocytes and Down-regulate Their TLR-2 and TLR-4 Expression Annals of Dermatology · 2011 · 37 citations
    11. Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation European journal of cell biology · 2004 · 36 citations
    12. Adiponectin Signaling Regulates Lipid Production in Human Sebocytes PLoS ONE · 2017 · 32 citations
    13. Effect of dihydrotestosterone on the upregulation of inflammatory cytokines in cultured sebocytes Archives of Dermatological Research · 2009 · 32 citations
    14. Androgens induce sebaceous differentiation in sebocyte cells expressing a stable functional androgen receptor 2015 · 31 citations
    15. Inhibition of the Androgen Receptor by Antisense Oligonucleotides Regulates the Biological Activity of Androgens in SZ95 Sebocytes Hormone and metabolic research · 2007 · 29 citations
    16. Activation of TRPV3 Inhibits Lipogenesis and Stimulates Production of Inflammatory Mediators in Human Sebocytes—A Putative Contributor to Dry Skin Dermatoses Journal of Investigative Dermatology · 2018 · 26 citations
    17. Expression of dermcidin in sebocytes supports a role for sebum in the constitutive innate defense of human skin Journal of Dermatological Science · 2015 · 25 citations
    18. Lipid droplets and associated proteins in sebocytes Experimental Cell Research · 2015 · 24 citations
    19. Ultraviolet B irradiation increases the expression of inflammatory cytokines in cultured sebocytes Journal of Dermatology · 2013 · 20 citations
    20. Vitamin D increases expression of cathelicidin in cultured sebocytes Archives of Dermatological Research · 2012 · 18 citations
    21. Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes Annals of Dermatology · 2019 · 8 citations
    22. Evaluation of the Effect of Plant Mixture Ethanol Extracts Containing Biota orientalis L. Extract on Suppression of Sebum in Cultured Sebocytes and on Stimulation of Growth of Keratinocytes Co-cultured with Hair Papilla Cells Cosmetics · 2017 · 4 citations
    23. Effect of Vitamin D on the Expression of Inflammatory Biomarkers in Cultured Sebocytes Treated with<i>Propionibacterium acnes</i>or Ultraviolet B Irradiation Annals of Dermatology · 2016 · 3 citations
    24. Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers Annals of Dermatology · 2011 · 3 citations
    25. 870 Y27632 promotes proliferation via EGFR signaling in a newly isolated and characterized human primary sebocyte cell line Journal of Investigative Dermatology · 2019
    26. 196 The endocannabinoid tone regulates human sebocyte biology Journal of Investigative Dermatology · 2016
    27. 1434 Epithelially derived MPZL3 negatively regulates murine and human sebaceous gland size and sebocyte proliferation Journal of Investigative Dermatology · 2023
    28. 548 Deletion of Myelin Protein Zero-like 3 increases sebaceous gland size and sebocyte proliferation but reduces skin adipose depots: Can MPZL3 inhibition promote excessive loss of lipids via sebum hypersecretion? Journal of Investigative Dermatology · 2022
    29. 724 MPZL3 functions as a negative regulator of sebaceous gland size and sebocyte proliferation 2022
    30. 498 Innate immunity activation of sebocyte cells by living bacteria. Evidence of a potential immunosuppressive effect of DHT 2019