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The Rotterdam Study investigates diseases in older adults and has produced many research findings.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Hair follicle biology advancements may lead to better hair growth disorder treatments.

PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.

Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Women with PCOS should be screened for heart disease risk and manage their health to prevent it.

Polycystic ovary syndrome affects about 6-10% of women, with varying symptoms and the need for standardized global definitions.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Off-pump heart surgery reduces complications without affecting survival rates compared to on-pump surgery.

Vitiligo is a skin condition causing white spots, more common in women, often starts before age 20, and can affect mental health.

The vitamin D receptor is involved in multiple body functions beyond calcium regulation, including immune response and rapid reactions not related to gene activity.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Keratins help protect cells, aid in cancer diagnosis, and influence cancer behavior and treatment.

Natural products in cosmetics are beneficial for skin and hair care with low toxicity.

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

Alopecia Areata is an autoimmune condition causing hair loss with no cure and treatments that often don't work well.

While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.

Testosterone therapy increases bone density in older men with low testosterone levels.

Most adult chronic hair pullers are women who started in their early teens, often have other mental health issues, and may pull hair due to underlying psychiatric conditions.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Polycystic ovary syndrome costs the U.S. over $4 billion a year, mainly from treating related health issues.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.