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    Glossary Proxalutamide

    experimental drug blocking male hormone effects

    Proxalutamide is an experimental drug that acts as a nonsteroidal antiandrogen, meaning it blocks the effects of androgens (male hormones) like testosterone. It is being studied for its potential use in treating conditions like prostate cancer and androgenetic alopecia (a common form of hair loss), by inhibiting the androgen receptors that contribute to these conditions.

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    Research 30 of 34

    1. Proxalutamide Reduces the Rate of Hospitalization for COVID-19 Male Outpatients: A Randomized Double-Blinded Placebo-Controlled Trial Frontiers in Medicine · 2021 · 42 citations
    2. Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial Cureus · 2021 · 41 citations
    3. Final Results of a Randomized, Placebo-Controlled, Two-Arm, Parallel Clinical Trial of Proxalutamide for Hospitalized COVID-19 Patients: A Multiregional, Joint Analysis of the Proxa-Rescue AndroCoV Trial Cureus · 2021 · 19 citations
    4. Proxalutamide Improves Inflammatory, Immunologic, and Thrombogenic Markers in Mild-to-Moderate COVID-19 Males and Females: an Exploratory Analysis of a Randomized, Double-Blinded, Placebo-Controlled Trial Early Antiandrogen Therapy (EAT) with Proxalutamide (The EAT-Proxa Biochemical AndroCoV-Trial) medRxiv (Cold Spring Harbor Laboratory) · 2021 · 5 citations
    5. Proxalutamide (GT0918) Reduces the Rate of Hospitalization in mild-to-moderate COVID-19 Female Patients: A Randomized Double-Blinded Placebo-Controlled Two-Arm Parallel Trial medRxiv (Cold Spring Harbor Laboratory) · 2021 · 5 citations
    6. Proxalutamide Reduction of Mortality Rate in Hospitalized COVID-19 Patients Depends on Treatment Duration – an Exploratory Analysis of the Proxa-Rescue AndroCoV Trial bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 5 citations
    7. Efficacy and safety of proxalutamide (GT0918) in severe or critically ill patients with COVID-19: study protocol for a prospective, open-label, single-arm, single-center exploratory trial BMC Pharmacology and Toxicology · 2023
    8. Expression of concern: potential risk for developing severe COVID-19 disease among anabolic steroid users BMJ case reports · 2021 · 21 citations
    9. An update of anti-viral treatment of COVID-19 Turkish Journal of Medical Sciences · 2021 · 51 citations
    10. Do Anti-androgens Have Potential as Therapeutics for COVID-19? Endocrinology · 2021 · 18 citations
    11. Drug repositioning approach to target ‎viral and host cells in terms of COVID-19 treatment: A review of ‎in vivo experiments and clinical studies Journal of experimental and clinical medicine · 2022
    12. Editor’s picks January 2021 Journal of the European Academy of Dermatology and Venereology · 2021
    13. Androgen receptor modulators: a review of recent patents and reports (2012-2018) Expert Opinion on Therapeutic Patents · 2019 · 23 citations
    14. COVID‐19, androgens, and androgenic alopecia Dermatological reviews · 2020 · 6 citations
    15. Correlation Between Nongenomic Action of C19-Steroids and COVID-19 Severity Physiological Research · 2021 · 3 citations
    16. Androgen deprivation therapy and hormonal status in men with COVID-19 Urology Herald · 2022
    17. Reply to comment on: The Gabrin sign Journal of The American Academy of Dermatology · 2020
    18. COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology Endocrine · 2021 · 68 citations
    19. Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Biochemical) Cureus · 2021 · 41 citations
    20. Role of testosterone in SARS-CoV-2 infection: A key pathogenic factor and a biomarker for severe pneumonia International Journal of Infectious Diseases · 2021 · 38 citations
    21. Alopecia in patients with COVID-19: A systematic review and meta-analysis JAAD International · 2022 · 25 citations
    22. Are sex hormones promising candidates to explain sex disparities in the COVID-19 pandemic? Reviews in endocrine and metabolic disorders · 2021 · 19 citations
    23. Immuno-Endocrinology of COVID-19: The Key Role of Sex Hormones Frontiers in Endocrinology · 2021 · 16 citations
    24. The immune response to COVID‐19: Does sex matter? Immunology · 2022 · 15 citations
    25. Association between Mineralocorticoid Receptor Antagonist and Mortality in SARS-CoV-2 Patients: A Systematic Review and Meta-Analysis Healthcare · 2022 · 10 citations
    26. Roles of steroid receptors in the lung and COVID-19 Essays in Biochemistry · 2021 · 9 citations
    27. Sex hormones in SARS-CoV-2 susceptibility: key players or confounders? Nature Reviews Endocrinology · 2022 · 8 citations
    28. Need for a Standardized Translational Drug Development Platform: Lessons Learned from the Repurposing of Drugs for COVID-19 Microorganisms · 2022 · 8 citations
    29. Antiandrogens as Therapies for COVID-19: A Systematic Review Cancers · 2024 · 6 citations
    30. Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients Viruses · 2022 · 5 citations