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The document concludes that immune system abnormalities cause alopecia areata, but the exact process is still not completely understood.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

The document is a detailed medical reference on skin and genetic disorders.

The document concludes that various dermatological treatments and drugs can cause skin reactions and side effects.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Herbal remedies can cause adverse effects and need more safety research.

Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

The mineralocorticoid receptor may play a role in skin and hair health and could be a new target for treating related disorders.

High levels of cortisol in hair show long-term stress which can lower fertility in animals.

Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

Skin symptoms are important for diagnosing and managing juvenile-onset systemic lupus erythematosus and usually get better with treatment.

Some diseases can improve the outcomes of other diseases, leading to new treatment possibilities.

More research is needed to understand hair and scalp disorders in people with skin of color.

High androgen levels can cause excessive hair growth and may indicate serious health issues, including heart disease and fertility problems.

Disrupting natural body clocks increases the risk of developing type 2 diabetes.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Estrogen loss during menopause worsens skin health, but hormone replacement therapy may improve it, though more research is needed.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Abnormal Hedgehog signaling in blood cancers may help tumors grow and resist chemotherapy, suggesting potential for targeted treatments.

The most common hair loss type at specialist clinics is androgenetic alopecia, especially in younger men, followed by alopecia areata and telogen effluvium, with differences seen across regions.

Cyproterone acetate is effective for treating hirsutism and acne but less so for hair loss, with side effects similar to birth control pills.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Steven Kossard classified lymphocyte-related hair loss into four patterns, each linked to different types of baldness.

Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.

Gene therapy shows promise for enhancing physical traits but faces ethical, safety, and regulatory challenges.

Progestogens are essential in menopausal hormone therapy to prevent uterine cancer and must be chosen carefully based on individual needs.