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In a conditional knockout mouse model, this study found that loss of the transcription elongation factor SPT6 in basal keratinocytes led to psoriasis-like skin inflammation and delayed wound healing, suggesting SPT6 plays a crucial role in maintaining epidermal immune quiescence by suppressing proinflammatory NF-κB signaling.

This review evaluates existing research on topical metformin for skin conditions, reporting promising outcomes such as improved wound healing, melasma, psoriasis, acne, and alopecia, with innovative formulations like hydrogels and lipid nanoparticles enhancing its cutaneous delivery while minimizing systemic exposure.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

This article provides clinical snippets from Experimental Dermatology and reports no new research findings.

R-spondin2 may help treat hair loss, gene differences could explain baldness, a peptide's regulation is linked to psoriasis, B-defensin gene copies may affect a skin condition's risk and severity, and potential markers and targets for alopecia areata were identified.

Low testosterone levels may contribute to female pattern hair loss in men.

This study found that sebaceous glands in bald scalp have greater androgen binding affinity and capacity than those in hairy scalp, possibly contributing to the androgenic response seen in male pattern baldness.

This study found that rhesus macaques with inhibited or anxious temperaments had less alopecia, suggesting temperament may influence hair loss in these animals.

This review examines the reliance on formalized and automated protocols in fields like aviation and medicine, suggesting that such approaches may hinder the human capability of mètis needed to handle emergencies and dynamic ambiguities; it reports no new results.

This retrospective cross-section study found that in a cohort of Pica patients in Iraq, 92.4% were female, and many had low levels of ferritin, hemoglobin, and vitamin D, which may contribute to the disorder by causing psychological issues.

This review discusses the interplay between polycystic ovary syndrome, aging, and fertility in women, and reports no new clinical results; the authors highlight pathways and interventions needing further research.

This paper reviews historical remedies for baldness from antiquity to the 19th century, reporting no new clinical results.

This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.

This review discusses the molecular role of the vitamin D receptor in regulating various biological actions such as bone mineralization and reports no new clinical results, highlighting the complexity of vitamin D's function in multiple tissues.

This review discusses the complex mechanisms regulating skin immunity to balance host defense with inflammation, but reports no new findings.

This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.

Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.

This review discusses the therapeutic potential of MSC-derived secretomes for treating degenerative and inflammatory diseases, reporting no new clinical results but highlighting their proposed mechanisms and advantages over direct MSC transplantation.

This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.

In this study, researchers showed that Wnt ligands secreted by hair follicle epithelium are crucial for hair follicle regeneration and may be significant for treating hair disorders like alopecia.

This study found that keratin 17 and TNFα play interdependent roles in regulating hair follicle cycling, with TNFα required for the anagen–catagen transition and its ablation partially rescuing hair cycling defects in K17-null mice.

This review discusses the molecular mechanisms by which oncogenic viruses contribute to cancer development through manipulation of host cellular functions and highlights the need for further research into virus-associated cancers, reporting no new results.

This review summarizes recent advances in Treg cell biology, focusing on Foxp3's role in immune regulation and therapeutic reprogramming for immune dysregulatory disorders, but reports no new clinical results.

This review discusses the historical development, mechanisms of action, and potential new clinical applications of the drug cepharanthine, highlighting its multi-faceted pharmacological properties; it reports no new clinical results.

This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.

This review discusses advanced techniques for investigating stem cell fate at the single-cell level, including lineage tracing, time-lapse imaging, and molecular profiling, but reports no new research results.

This review found that olive oil phenols may have anti-cancer properties in animal models and some human studies, but further research is needed to confirm these effects in humans.

This review discusses recent discoveries about the role of Eda and other TNF-related cytokines in skin appendage development and reports no new experimental results, highlighting developments since the last comprehensive summary in 2003.

This study found that NF-κB signaling may connect injury response to regenerative processes in zebrafish hearts, potentially aiding the development of cardiac regenerative therapies in humans.