December 2025 in “Journal of Human Immunity” In this case report, a 37-year-old patient with APECED showed significant clinical improvement, including hair regrowth and resolution of skin issues, after 11 months of treatment with ruxolitinib, highlighting the potential of JAK inhibitors in managing this complex autoimmune disease.
October 2017 in “The American Journal of Gastroenterology” This case report details a 71-year-old man diagnosed with Cronkhite-Canada Syndrome, highlighting the importance of early diagnosis and endoscopic evaluation due to the disease's progressive nature and significant mortality risk.
August 2013 in “Gastroenterology” This case report highlights a 60-year-old patient's diagnosis with Cronkhite-Canada syndrome, characterized by gastrointestinal polyps, diarrhea, weight loss, brittle nails, alopecia, and skin changes, which showed improvement with treatment.
April 2014 in “Jurnal Biomedik : JBM” This case report diagnosed an 8-year-old girl with trachyonychia and secondary onychomycosis, finding that spontaneous improvement is common, making specific therapy often unnecessary despite treatment challenges with associated fungal infections.
10 citations
,
July 2001 in “PubMed” This case report describes two patients with a likely new type of pachyonychia, characterized by nail thickening and severe generalized hypotrichosis, possibly linked to a mutation in a hard keratin.
1 citations
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October 2019 in “International journal of contemporary pediatrics” This case report highlights a 12-year-old boy with twenty nail dystrophy in isolation, emphasizing the need for thorough physical exams to distinguish nail disorders and provide appropriate management and counseling on the condition's benign nature and good prognosis.
2 citations
,
December 2013 in “The Journal of Dermatology” This article is a letter to the editor about onychogryphosis associated with an elastic wire, and reports no new research findings.
September 2022 in “JAAD case reports” This case study of a 45-year-old man from Tonga describes the identification of pachyonychia congenita through genetic testing, revealing a mutation in the keratin gene KRT16, associated with chronic painful skin and nail conditions.
7 citations
,
August 2005 in “British Journal of Dermatology” This study reported improvement of psoriatic onychopachydermoperiostitis symptoms with the use of etanercept.
4 citations
,
May 2022 in “Journal of Nepal Medical Association” This case report describes a 40-year-old woman with Cronkhite-Canada Syndrome whose symptoms, including gastrointestinal issues and skin changes, improved significantly with corticosteroids, co-infection treatment, and nutritional counseling.
1 citations
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January 1980 in “Archives of Dermatology” This exchange discusses interpretations of syphilitic chancres, noting disagreement over whether multiple lesions are atypical given historical references that describe primary chancres as often being single.
November 2009 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas” Hair transplantation effectively treated a bald patch in an 18-year-old woman with Temporal Triangular Alopecia.
September 2016 in “European Journal of Pediatric Dermatology/PD. European journal of pediatric dermatology” This article discusses the characteristics and challenges of treating ulerythema ophryogenes, noting the limited effectiveness of emollients, vitamin A, retinoids, and transient response to corticosteroids, with some success using dye laser therapy.
5 citations
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March 2013 in “International journal of surgical pathology” This case report illustrates that a diagnosis of Cronkhite-Canada syndrome can be made without the presence of polyps, as demonstrated by resolving symptoms with steroid treatment.
February 2022 in “Authorea (Authorea)” This report presents a case of a seven-year-old girl with porokeratotic adnexal ostial nevus manifesting as hyperkeratotic verrucous papules on her left foot.
58 citations
,
November 1969 in “British Journal of Dermatology” This report describes two patients with ichthyosis linearis circumflexa exhibiting symptoms resembling Netherton's disease, noting multiple hair shaft defects and discussing a possible connection to aminoaciduria.
17 citations
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July 1984 in “British journal of dermatology/British journal of dermatology, Supplement” This study describes a distinctive form of ichthyosis characterized by abnormal epidermal differentiation mainly within hair follicles in four patients with congenital follicular hyperkeratosis.
2 citations
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January 2007 in “Journal of The American Academy of Dermatology” Red and infrared light therapy improves hair growth in balding patients.
January 2007 in “Journal of the American Academy of Dermatology” A 73-year-old man's grey-white hair turned dark brown after eczema treatment.
September 2024 in “Cureus” This case report outlines a 10-year-old boy who experienced a six-year history of twenty-nail dystrophy, highlighting the importance of physical examination for early diagnosis and management of nail disorders, with his primary symptoms involving nail disfigurement and alopecia areata, but no other health issues.
2 citations
,
August 2014 in “Archivos argentinos de pediatría” This report describes a 6-year-old girl with Turner syndrome and coexisting psoriasis, alopecia areata, and trachyonychia, suggesting a potential link between these conditions.
4 citations
,
December 2013 in “The Journal of Dermatology” This letter to the editor discusses a case of delayed-onset pachyonychia congenita linked to a new mutation in keratin 6b but presents no new research findings.
17 citations
,
April 1997 in “American Journal of Dermatopathology” This report provides the first microscopic description of pachyonychia congenita-associated alopecia, identifying a combination of histological features that might be unique to this condition.
4 citations
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June 2014 in “The Journal of Dermatology” Elkonyxis, a rare nail condition, improved when patients stopped their nail-picking habits.
48 citations
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May 1999 in “International Journal of Dermatology” This article reviews the diagnosis and management of alopecia areata but reports no new research findings.
21 citations
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April 2014 in “PLoS ONE” In this study, researchers identified a novel KRT74 gene mutation associated with autosomal recessive pure hair and nail ectodermal dysplasia in a Pakistani family, expanding the known genetic causes of the disorder.
21 citations
,
January 2013 in “Clinical Endoscopy” This study reports the first case in South Korea of Cronkhite-Canada syndrome associated with malignant colon polyp and serrated adenoma.
17 citations
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September 2010 in “Pediatric dermatology” This report describes a case of widespread Porokeratotic eccrine and hair follicle nevus in a 15-year-old woman with keratitis-ichthyosis-deafness syndrome, involving both eccrine ostia and hair follicle infundibula.
16 citations
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May 2013 in “Australasian Journal of Dermatology” In this study, detailed examinations of alopecic lesions in two female Cronkhite-Canada syndrome patients suggested hair regrowth might occur without systemic corticosteroids if not required for gastrointestinal treatment, and hair loss may begin with anagen-telogen transition.
9 citations
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April 2018 in “Journal of Dermatological Treatment” This study found that oral tofacitinib monotherapy improved nail changes in 73.3% of adults with moderate-to-severe alopecia areata over a median period of 5 months, but nail improvement was not linked to the severity of hair loss or hair regrowth.