A Rare Case of Cronkhite-Canada Syndrome

Cronkhite-Canada Syndrome (CCS) was a rare, non-hereditary polyposis condition with an incidence of 1 case per million people. It presented with symptoms such as diarrhea, anorexia, weight loss, alopecia, onychodystrophy, and cutaneous hyperpigmentation. A 71-year-old male patient with a history of irritable bowel syndrome and other conditions developed worsening diarrhea, dysgeusia, anorexia, and significant weight loss over five months. Endoscopic evaluations revealed diffuse polyposis, leading to a CCS diagnosis. Treatment included dietary supplements and symptom management with loperamide and simethicone, while the patient declined steroids. CCS was associated with complications like malabsorption and increased colon cancer risk, making early diagnosis and nutritional support crucial. Glucocorticoids were the most effective therapy, and polyp sampling was recommended for cancer prevention.