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GlossaryNuclear Translocation

process where molecules move from cytoplasm to nucleus

Nuclear translocation refers to the process by which molecules, such as proteins or transcription factors, move from the cytoplasm of a cell into its nucleus. This movement is crucial for regulating gene expression, as these molecules often need to interact with DNA to activate or repress specific genes. For example, in the context of hair biology, certain signaling proteins might undergo nuclear translocation to influence the growth and health of hair follicles.

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research Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain During Epidermal Differentiation

25 citations, October 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.

research Cyclosporine A Increases Hair Follicle Growth by Suppressing Apoptosis-Inducing Factor Nuclear Translocation: A New Mechanism

9 citations, January 2015 in “Fundamental & clinical pharmacology”

Cyclosporine A helps hair grow by blocking a process that would otherwise cause hair cells to die.

research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 In Vivo

52 citations, May 1997 in “Journal of Biological Chemistry”

High ornithine decarboxylase levels may lead to hair loss and cancer by increasing CK2 activity in the nucleus.

A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

91 citations, May 2005 in “The Journal of Clinical Endocrinology & Metabolism”

A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

research Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome

34 citations, July 2020 in “American journal of human genetics”

Changes in the SREBF1 gene cause a rare genetic skin and hair disorder.

research Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways

14 citations, September 2018 in “International Journal of Molecular Sciences”

Mackerel-derived fermented fish oil helps hair grow by activating growth pathways and increasing cell proliferation.

4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

5 citations, February 2017 in “Biomolecules & Therapeutics”

4-O-Methylhonokiol helps protect skin cells from growth-stopping effects of a protein by regulating growth-related pathways.

research Functional Analysis of Vitamin D Receptor Using Adenovirus Vector

4 citations, February 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology”

The study found that certain mutations in the vitamin D receptor can cause rickets and potentially affect hair growth.

research Targeting Receptor–Regulator Interactions

August 2013 in “Nature Reviews Drug Discovery”

New treatments for cancer and skin disorders show promise in disrupting harmful cell interactions and promoting hair growth.

research A New Way to Restore Tumor Suppressor Function

August 2013 in “Nature Reviews Drug Discovery”

New treatments may restore cancer-blocking proteins, slow prostate cancer, identify drug targets, and potentially regrow hair.

research Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling

42 citations, July 2017 in “Molecular therapy”

A form of vitamin E promotes hair growth by activating a specific skin pathway.

PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

26 citations, August 2019 in “Stem Cell Research & Therapy”

PBX1 helps hair stem cells grow and change by turning on certain cell signals and preventing cell death, which may be useful for hair regrowth treatments.

research Effects of Dihydrotestosterone on Rat Dermal Papilla Cells In Vitro

19 citations, April 2015 in “European Journal of Pharmacology”

Dihydrotestosterone (DHT) doesn't affect rat skin cell growth, but it does change cell cycle, protein levels, and other cell functions, potentially shortening hair growth cycle.

research Regulation of Hair Shedding by the Type 3 IP3 Receptor

19 citations, May 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

The type 3 IP3 receptor is important for controlling hair loss and growth.

research Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice: A Mechanistic Systematic Review

10 citations, August 2022 in “International Journal of Molecular Sciences”

Leptin-deficient mice, used as a model for Type 2 Diabetes, have delayed wound healing due to impaired contraction and other dysfunctional cellular responses.

research Human-Derived Immortalized Dermal Papilla Cells With Constant Expression of Androgen Receptor

8 citations, March 2020 in “Frontiers in Cell and Developmental Biology”

Researchers created immortal human skin cells with constant testosterone receptor activity to study hair loss and test treatments.

research Secreted Frizzled-Related Protein 4 Inhibits the Regeneration of Hair Follicles

7 citations, January 2019 in “PeerJ”

A protein called sFRP4 can slow down hair regrowth.

research Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways

5 citations, December 2018 in “Biological & Pharmaceutical Bulletin”

Norgalanthamine helps hair cells grow by activating certain pathways related to hair growth.

research CRABP1 Enhances Proliferation of Dermal Papilla Cells in Hu Sheep via Wnt/β-Catenin Pathway

September 2024 in “Genes”

CRABP1 boosts hair cell growth in Hu sheep by affecting key genes.

Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

research Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

May 2024 in “Archives of dermatological research”

Enz_MoriL from mulberry leaves helps hair growth by affecting specific cell pathways.

Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus

research Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus

April 2023 in “Journal of Investigative Dermatology”

PTEN was identified as a specific marker for the skin disease cutaneous lupus erythematosus, and it helps increase the expression of harmful type I interferons.

research Chaperones as Thermodynamic Sensors

August 2013 in “Nature Reviews Drug Discovery”

New cancer treatments show promise in reducing tumor growth and improving skin regeneration in mice.

research Regulatory Effect of 4-O-Methylhonokiol on TGF-β1-Induced Cell Cycle Arrest in Human Keratinocyte Cell Line (HaCaT)

August 2011 in “Planta Medica”

4-O-methylhonokiol from Magnolia Officinalis may promote hair growth by interfering with TGF-β1 effects in skin cells.

research The Role of Nuclear Hormone Receptors in Cutaneous Wound Repair

68 citations, December 2014 in “Cell Biochemistry and Function”

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

research Hairless Is a Nuclear Receptor Corepressor Essential for Skin Function

30 citations, January 2009 in “Nuclear Receptor Signaling”

Hairless protein is crucial for healthy skin and hair, and its malfunction can cause hair loss.

research Expression and Function of Nuclear Receptor Co-Activator 4: Evidence of a Potential Role Independent of Co-Activator Activity

26 citations, May 2012 in “Cellular and Molecular Life Sciences”

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

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Related Terms

Research

research Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain During Epidermal Differentiation

research Cyclosporine A Increases Hair Follicle Growth by Suppressing Apoptosis-Inducing Factor Nuclear Translocation: A New Mechanism

research Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 In Vivo

research A Novel Point Mutation in the Ligand-Binding Domain of the Human Glucocorticoid Receptor Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus in Conferring Transactivational Activity

research Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome

research Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways

research 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling

research Functional Analysis of Vitamin D Receptor Using Adenovirus Vector

research Targeting Receptor–Regulator Interactions

research A New Way to Restore Tumor Suppressor Function

research Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling

research PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis

research Effects of Dihydrotestosterone on Rat Dermal Papilla Cells In Vitro

research Regulation of Hair Shedding by the Type 3 IP3 Receptor

research Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice: A Mechanistic Systematic Review

research Human-Derived Immortalized Dermal Papilla Cells With Constant Expression of Androgen Receptor

research Secreted Frizzled-Related Protein 4 Inhibits the Regeneration of Hair Follicles

research Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways

research CRABP1 Enhances Proliferation of Dermal Papilla Cells in Hu Sheep via Wnt/β-Catenin Pathway

research Hair Growth-Promoting Effects of Enz MoriL on Human Dermal Papilla Cells Through Modulation of the Wnt/β-Catenin and JAK-STAT Signaling Pathways

research Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus

research Chaperones as Thermodynamic Sensors

research Regulatory Effect of 4-O-Methylhonokiol on TGF-β1-Induced Cell Cycle Arrest in Human Keratinocyte Cell Line (HaCaT)

research The Role of Nuclear Hormone Receptors in Cutaneous Wound Repair

research Hairless Is a Nuclear Receptor Corepressor Essential for Skin Function

research Expression and Function of Nuclear Receptor Co-Activator 4: Evidence of a Potential Role Independent of Co-Activator Activity

research Nuclear Factor I-C Regulates TGF-β-dependent Hair Follicle Cycling

research Hairless: A Nuclear Receptor Corepressor Essential for Skin Function

research The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed

research Non-Canonical Dimerization of the Androgen Receptor and Other Nuclear Receptors: Implications for Human Disease