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    Glossary Nuclear Translocation

    process where molecules move from cytoplasm to nucleus

    Nuclear translocation refers to the process by which molecules, such as proteins or transcription factors, move from the cytoplasm of a cell into its nucleus. This movement is crucial for regulating gene expression, as these molecules often need to interact with DNA to activate or repress specific genes. For example, in the context of hair biology, certain signaling proteins might undergo nuclear translocation to influence the growth and health of hair follicles.

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    1. Characterization of Mouse Profilaggrin: Evidence for Nuclear Engulfment and Translocation of the Profilaggrin B-Domain during Epidermal Differentiation 2002 · 25 citations
    2. Detection of the nuclear translocation of androgen receptor using quantitative and automatic cell imaging analysis Tissue and Cell · 2024
    3. Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway International Journal of Medical Sciences · 2013 · 57 citations
    4. Cyclosporine A increases hair follicle growth by suppressing apoptosis-inducing factor nuclear translocation: a new mechanism Fundamental & clinical pharmacology · 2015 · 9 citations
    5. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations
    6. Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome American journal of human genetics · 2020 · 34 citations
    7. Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers Journal of Cellular Biochemistry · 2017 · 15 citations
    8. Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways International Journal of Molecular Sciences · 2018 · 14 citations
    9. Regulatory effect of β-catenin on proliferation of hair follicle stem cells involves PI3K/Akt pathway Journal of Applied Biomedicine · 2013 · 11 citations
    10. 4-<i>O</i>-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling Biomolecules & Therapeutics · 2017 · 5 citations
    11. Functional analysis of vitamin D receptor (VDR) using adenovirus vector 2023 · 4 citations
    12. PRF Lysates Modulate Chemokine Expression in Oral Squamous Carcinoma and Healthy Epithelial Cells Bioengineering · 2024 · 2 citations
    13. Nutrients regulation of skin cells from canines and cats via Wnt/β-catenin signaling pathway Frontiers in Veterinary Science · 2025
    14. Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo Journal of Biological Chemistry · 1997 · 52 citations
    15. Too Many Follistatins: Racing Inside and Getting Out of the Cell Endocrinology · 2005 · 13 citations
    16. A new way to restore tumour suppressor function Nature Reviews Drug Discovery · 2013
    17. Targeting receptor–regulator interactions Nature Reviews Drug Discovery · 2013
    18. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size Molecular Cell · 2018 · 90 citations
    19. Effects of the androgen receptor overexpression in prostate cancer 2007
    20. Epidermal E-Cadherin Dependent β-Catenin Pathway Is Phytochemical Inducible and Accelerates Anagen Hair Cycling Molecular therapy · 2017 · 42 citations
    21. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    22. Effects of dihydrotestosterone on rat dermal papilla cells in vitro European Journal of Pharmacology · 2015 · 19 citations
    23. Regulation of Hair Shedding by the Type 3 IP3 Receptor 2012 · 19 citations
    24. Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling Stem Cell Research & Therapy · 2021 · 11 citations
    25. Wound Healing Impairment in Type 2 Diabetes Model of Leptin-Deficient Mice—A Mechanistic Systematic Review International Journal of Molecular Sciences · 2022 · 10 citations
    26. Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor Frontiers in Cell and Developmental Biology · 2020 · 8 citations
    27. Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles PeerJ · 2019 · 7 citations
    28. Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells <i>via</i> Anagen-Activating Signaling Pathways Biological & Pharmaceutical Bulletin · 2018 · 5 citations
    29. FAM19A5 negatively regulates cutaneous wound healing via PPARD-dependent inhibition of keratinocyte migration Scientific Reports · 2026
    30. Matrix Stiffness-driven FAK Splicing Tunes Cell Mechanosensing bioRxiv (Cold Spring Harbor Laboratory) · 2026