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    Glossary Notch3

    gene involved in cell signaling and tissue development

    Notch3 is a gene that encodes a protein involved in cell signaling, which plays a crucial role in the development and function of various tissues, including blood vessels and the nervous system. Mutations in the Notch3 gene are associated with CADASIL, a genetic disorder that leads to stroke and dementia.

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    1. Epidermal Notch signalling: differentiation, cancer and adhesion Current opinion in cell biology · 2008 · 253 citations
    2. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    3. Localisation of members of the notch system and the differentiation of vibrissa hair follicles: Receptors, ligands, and fringe modulators Developmental dynamics · 2000 · 62 citations
    4. JMJD3 and NF-κB-dependent activation of Notch1 gene is required for keratinocyte migration during skin wound healing Scientific Reports · 2017 · 54 citations
    5. Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1 Development · 2010 · 34 citations
    6. Pleiotropic Role of Notch Signaling in Human Skin Diseases International Journal of Molecular Sciences · 2020 · 29 citations
    7. Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch Biochemical and Biophysical Research Communications · 2014 · 8 citations
    8. Role of Aire and Notch4 Allelic Mutations in Alopecia Areata in C3H/HeJ Mice JID Innovations · 2026
    9. Epidermal Notch1 recruits innate lymphoid cells to orchestrate normal skin repair Durham e-Theses (Durham University) · 2014
    10. Mouse notch: expression in hair follicles correlates with cell fate determination. 1993 · 150 citations
    11. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling Development · 2011 · 134 citations
    12. Impaired Notch‐MKP‐1 signalling in hidradenitis suppurativa: an approach to pathogenesis by evidence from translational biology Experimental dermatology · 2013 · 112 citations
    13. Activation of the Notch pathway in the hair cortex leads to aberrant differentiation of the adjacent hair-shaft layers Development · 2000 · 109 citations
    14. Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair Nature Communications · 2016 · 86 citations
    15. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    16. Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis Journal of Investigative Dermatology · 2007 · 78 citations
    17. Melanoblasts' Proper Location and Timed Differentiation Depend on Notch/RBP-J Signaling in Postnatal Hair Follicles 2008 · 70 citations
    18. Genetic interplays between Msx2 and Foxn1 are required for Notch1 expression and hair shaft differentiation Developmental Biology · 2008 · 67 citations
    19. Notch Signaling Regulates Late-Stage Epidermal Differentiation and Maintains Postnatal Hair Cycle Homeostasis PloS one · 2011 · 61 citations
    20. Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway International Journal of Medical Sciences · 2013 · 57 citations
    21. Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway Stem Cell Research & Therapy · 2021 · 39 citations
    22. Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway Biochimie · 2016 · 36 citations
    23. Accelerated Endothelial to Mesenchymal Transition Increased Fibrosis via Deleting Notch Signaling in Wound Vasculature Journal of Investigative Dermatology · 2017 · 26 citations
    24. Notch signaling is significantly suppressed in basal cell carcinomas and activation induces basal cell carcinoma cell apoptosis Molecular Medicine Reports · 2017 · 18 citations
    25. The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development 2016 · 16 citations
    26. Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway Life sciences · 2020 · 11 citations
    27. Pyridoxine regulates hair follicle development via the PI3K/Akt, Wnt and Notch signalling pathways in rex rabbits Animal nutrition · 2021 · 10 citations
    28. Notch1 Signaling Regulates Wound Healing via Changing the Characteristics of Epidermal Stem Cells Journal of Stem Cell Research & Therapy · 2016 · 6 citations
    29. MiR-23b and miR-133 Cotarget TGFβ2/NOTCH1 in Sheep Dermal Fibroblasts, Affecting Hair Follicle Development Cells · 2024 · 4 citations
    30. Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg–like Cells, and Common EGFR Somatic Mutations The American Journal of Surgical Pathology · 2021 · 4 citations