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Did you mean N-Acetylcysteine?

Glossary N-Acetylcysteine

supplement that replenishes antioxidant glutathione and supports detoxification

N-Acetylcysteine (NAC) is a supplement and medication derived from the amino acid L-cysteine. It is commonly used to help replenish levels of the antioxidant glutathione in the body, support liver detoxification, and treat conditions like acetaminophen overdose and chronic respiratory issues. NAC has also been studied for its potential benefits in promoting hair growth and treating certain types of alopecia due to its antioxidant properties.

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research Into the redox control: N-acetyl-cysteine pleiotropic effects from the laboratory to clinical applications

4 citations , December 2013 in “Acupuncture and related therapies”

This review summarizes the potential of N-acetyl-cysteine in managing diseases linked to redox imbalance, discussing its effects from cellular mechanisms to clinical applications, though further research is suggested for broader use.

research Comparison of N-acetyl cysteine with metformin on clinical profile in anovulatory infertile women with PCOS

May 2018 in “International journal of clinical obstetrics and gynaecology”

This study found that N-acetyl cysteine and metformin had equal effects on clinical outcomes in anovulatory infertile women with PCOS, but NAC was better tolerated with fewer side effects.

research TRAIL sensitization of PC3 prostate cancer cells by doxorubicin can be blocked by the anti-oxidant N-acetyl-cysteine or by the iron chelator deferoxamine

October 2006 in “Clinical Cancer Research”

This study found that doxorubicin-induced oxidative stress downregulates FLIPs and phosphorylates EF2, sensitizing prostate cancer cells to TRAIL; antioxidants may reduce doxorubicin's effectiveness, warranting further investigation.

research Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

October 2021 in “QJM: An International Journal of Medicine”

This study found that N-acetyl-cysteine alone or combined with minoxidil improved hair parameters in men with early-onset androgenetic alopecia, with tolerable side effects.

research N-acetylcysteine in the treatment of trichotillomania

65 citations , January 2012 in “International Journal of Trichology”

This case report describes two patients with trichotillomania who were successfully treated with N-acetylcysteine, suggesting it as a potential new management option, though further studies are needed.

research Suppression of uterine and placental ferroptosis by N-acetylcysteine in a rat model of polycystic ovary syndrome

53 citations , November 2021 in “Molecular Human Reproduction”

This study found that the antioxidant N-acetylcysteine attenuated ferroptosis in the uterus and placenta of a PCOS-like rat model, indicating its potential as a therapeutic strategy for PCOS-related complications.

research Trichotillomania: a good response to treatment with N-acetylcysteine

27 citations , August 2017 in “Anais Brasileiros de Dermatologia”

In this case report, a patient with trichotillomania showed a significant positive response to treatment with N-acetylcysteine, suggesting its potential effectiveness for this disorder according to the authors’ observations.

research Trichotillomania treated with n-acetylcysteine

3 citations , May 2018 in “Psychiatry and Clinical Psychopharmacology”

In this report, an 18-year-old female with trichotillomania was successfully treated using the glutamate modulator n-acetylcysteine.

research Comparison of metformin and N-acetylcysteine on metabolic parameters in women with polycystic ovarian syndrome

1 citations , June 2017 in “International journal of reproduction, contraception, obstetrics and gynecology”

This study found that N-acetylcysteine was as effective as metformin in improving insulin resistance and metabolic syndrome parameters in women with polycystic ovary syndrome, with fewer side effects.

Effect of N-Acetylcysteine on Hair Follicle Changes in Mouse Model of Cyclophosphamide-Induced Alopecia: Histological and Biochemical Study

research Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study

April 2024 in “Histochemistry and cell biology”

In this study, NAC was observed to counteract the negative effects of cyclophosphamide on hair follicles in mice, preserving both biochemical parameters and hair structure, suggesting its potential as a therapeutic option for chemotherapy-induced hair loss.

research A case of trichotillomania with bulimia: combined with N-acetylcysteine synergistic therapy

April 2021 in “Research Square (Research Square)”

This case report describes significant improvements in both trichotillomania and bulimia symptoms with N-acetylcysteine treatment, suggesting a potential shared pathophysiological mechanism between the disorders.

Treatment with ImuVert and N-Acetylcysteine Protects Rats from Cyclophosphamide and Cytarabine-Induced Alopecia

research Treatment with ImuVert/JV-Acetylcysteine Protects Rats from Cyclophosphamide/ Cytarabine-Induced Alopecia

26 citations , January 1992 in “Cancer investigation”

This study found that N-acetylcysteine effectively prevented cyclophosphamide-induced alopecia in rats, and ImuVert plus N-acetylcysteine prevented alopecia from a cyclophosphamide-cytarabine combination.

Evidence of Hair Loss After Subacute Exposure to 2-Chloroethyl Ethyl Sulfide, a Mustard Analog, and Beneficial Effects of N-Acetylcysteine

research Evidence of hair loss after subacute exposure to 2-chloroethyl ethyl sulfide, a mustard analog, and beneficial effects ofN-acetyl cysteine

14 citations , January 2004 in “Journal of Biochemical and Molecular Toxicology”

This study found that sudden hair loss in guinea pigs may serve as a potential biomarker for subacute exposure to mustard gas, and pre-treatment with N-acetylcysteine could prevent this hair loss.

research Influence of FHIT on benzo[ a ]pyrene-induced tumors and alopecia in mice: Chemoprevention by budesonide and N -acetylcysteine

24 citations , May 2006 in “Proceedings of the National Academy of Sciences of the United States of America”

This study reported that heterozygosity for FHIT affects mice's susceptibility to spontaneous alopecia areata and to certain preneoplastic lesions induced by benzo[a]pyrene, but does not change how they respond to budesonide and N-acetyl-L-cysteine.

research Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles

17 citations , December 2002 in “Biochemical and biophysical research communications”

This study reports on the biochemical characteristics of S100A3 protein in human hair cuticle, notably finding its N-terminal methionine is acetylated and has a slightly lower isoelectric point compared to the recombinant version.

research Trichotillomania

219 citations , September 2016 in “American Journal of Psychiatry”

This article reviews trichotillomania, highlighting its differences from OCD and recommending treatments like habit reversal therapy and specific medications, but reports no new clinical results.

research Particulate matter 2.5 damages skin cells by inducing oxidative stress, subcellular organelle dysfunction, and apoptosis

215 citations , March 2018 in “Archives of Toxicology”

This study found that PM2.5 exposure induced oxidative stress in human keratinocytes and mouse skin, causing cellular damage, which was mitigated by the antioxidant N-acetyl cysteine.

research Polycystic Ovary Syndrome: A Comprehensive Review of Pathogenesis, Management, and Drug Repurposing

68 citations , January 2022 in “International Journal of Molecular Sciences”

This review summarizes factors involved in polycystic ovary syndrome pathogenesis and management, highlights commonly prescribed and repurposed medications, and calls for well-designed clinical trials to evaluate these treatments further.

Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

research Induction of transforming growth factor-beta 1 by androgen is mediated by reactive oxygen species in hair follicle dermal papilla cells

56 citations , September 2013 in “Journal of Biochemistry and Molecular Biology”

This study observed that androgen treatment increased ROS production and TGF-β1 secretion in rat hair follicle dermal papilla cells, suggesting that the androgen-induced TGF-β1 is mediated by ROS.

research Pharmacotherapy of polycystic ovary syndrome - an update

34 citations , January 2011 in “Fundamental & Clinical Pharmacology”

This review summarizes various treatment options for polycystic ovary syndrome, noting that while some treatments address specific symptoms, no single therapy fully resolves the condition.

research Monilethrix: A rare hereditary condition

12 citations , January 2013 in “Indian Journal of Dermatology”

This case report on a 13-year-old boy with monilethrix observed slight improvement after a two-month trial of oral N-acetyl cysteine, but overall hair density did not improve further.

research Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes

9 citations , September 2017 in “Journal of Investigative Dermatology Symposium Proceedings”

In this study, PGD2 was shown to increase testosterone production in human keratinocytes through reactive oxygen species, suggesting potential benefits of antioxidants like N-acetyl-cysteine for AGA patients.

research BMI1 is required for melanocyte stem cell maintenance and hair pigmentation

4 citations , May 2023 in “Pigment Cell & Melanoma Research”

In this study, researchers found that deleting the Bmi1 gene in murine melanocytes caused premature hair greying and loss of melanocyte lineage cells, highlighting BMI1's role in protecting melanocyte stem cells from stress and oxidative damage.

research Diagnosis and treatment of trichotillomania

3 citations , April 2011 in “Neuropsychiatry”

This review discusses the potential factors contributing to trichotillomania and reports that behavioral therapy, N-acetyl cysteine, and olanzapine may be beneficial for those affected; it provides no new clinical results.

research Hirsutism: Diagnosis and Treatment

2 citations , January 2012 in “Journal of metabolic syndrome”

This review summarizes current knowledge on the diagnosis and treatment of hirsutism but provides no new clinical results.

research A case of trichotillomania presenting as a factitious ulcer

January 2023 in “Odisha Journal of Psychiatry”

This case study describes a patient initially misdiagnosed with pediculosis capitis, later identified as having trichotillomania, highlighting the importance of thorough behavioral inquiries by physicians in such cases.

research Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway

January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology”

This study found that minoxidil increases trabecular meshwork cell permeability, possibly via the downregulation of tight junction proteins and the generation of reactive oxygen species.

research Trichotillomania and Traction Alopecia

May 2017 in “InTech eBooks”

This review discusses trichotillomania and traction alopecia, focusing on their clinical features, diagnostic criteria, and treatment options, but it reports no new research findings.

research Trichotillomania.

April 2016 in “Apollo (University of Cambridge)”

This article reviews treatment approaches for trichotillomania, emphasizing differences from OCD therapies and recommending specific management strategies, without providing new experimental findings.

research Botanical Treatment for Polycystic Ovary Syndrome

January 2009 in “Elsevier eBooks”

This chapter reviews botanical treatments for polycystic ovary syndrome, discussing potential benefits but presenting no new clinical results; it emphasizes the use of botanicals for managing symptoms like anovulation, insulin resistance, and inflammation.