research Loss of UBE2N in Keratinocytes Leads to Skin Inflammation and Immune Infiltration Through IRAK1/4-Mediated Processes
Removing UBE2N from skin cells causes inflammation and immune response, which can be lessened with specific inhibitors.
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research Skin Aging and Hair Follicle Stem Cell Dysfunction Caused by T Cells With Defective Mitochondrial Metabolism
Defective T cell metabolism can cause early skin aging and poor hair follicle stem cell function.
research Uncoupling Desmosomal Cadherin Adhesion Activates Quiescent Hair Follicle Stem Cells and Orchestrates Self-Organized Regeneration Through Outside-In Signaling
Disrupting a specific protein's function in hair follicle stem cells triggers their activation and a self-healing process.
research Type 2-Mediated Oxidative Reprogramming Promotes Macrophage Transition into Repair Mode for Wound Healing
Type 2 inflammation helps wound healing by switching immune cells to repair mode.
research Epidermal Growth Factor Receptor Protects From Immune Privilege Collapse and Scarring Hair Follicle Destruction
Blocking EGFR can lead to hair loss due to inflammation and stem cell damage.
research Fate Tracing of DNA-Damaged Hair Follicle Stem Cells and Their Seno-Differentiation Clearance Out of the Niche
Damaged hair follicle stem cells may leave the skin to help maintain youthfulness.
research Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation
Key skin cell regulators and gene organization changes are crucial for skin cell development and could help treat skin disorders.
research Lrig1-Expressing Epidermal Progenitors Require SCD1 to Maintain the Dermal Papilla Niche
Hair growth-related cells need the enzyme SCD1 to help maintain the area that supports hair growth.
research Newly Born Mesenchymal Cells Disperse Through Rapid Mechanosensitive Migration
Newly born mesenchymal cells quickly spread out in response to tissue tension during early development.
research Loss of TET2 Tips the Scales Toward Tumorigenesis
Loss of TET2 increases the risk of skin and oral cancer.