23 citations
,
January 2015 in “Journal of The American Academy of Dermatology” This study found that patients with myotonic dystrophy type 1 had higher numbers of nevi, dysplastic nevi, melanomas, and pilomatrixomas compared to age- and sex-matched controls.
4 citations
,
January 2019 in “Micron” This study observed that fetal hair follicle melanocytes varied in morphology and development stages, with melanosomes undergoing degradation into irregular pigment particles within keratinocytes.
11 citations
,
August 1986 in “Archives of Dermatology” This case report describes a patient with skin and nail hyperpigmentation and premature gray hair due to vitamin B12 deficiency, which were reversed after treatment with cyanocobalamin.
240 citations
,
April 2011 in “Pigment Cell & Melanoma Research” This review discusses the identification and characteristics of melanocyte stem cells, emphasizing their role in hair pigmentation, greying, and skin repigmentation, but reports no new research findings.
20 citations
,
January 2015 in “Current problems in dermatology” This paper reviews recent research on hair graying, suggesting that an imbalance in oxidative stress handling may affect melanocyte stem cells and melanin production with age, and calls for exploring strategies to prolong melanin production.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers used single-cell RNA sequencing to define and locate three distinct cell states of melanocytes in mouse skin development, potentially aiding the understanding of abnormal melanocyte differentiation.
2 citations
,
March 2023 in “JAAD case reports” This case report describes the unexpected hair repigmentation surrounding a scalp tumor in a 74-year-old man, suggesting a potential link between the carcinoma and changes in hair pigmentation.
16 citations
,
January 2008 in “Acta dermato-venereologica” Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.
September 2017 in “Journal of Investigative Dermatology Symposium Proceedings” This report highlights four cases where squamous cell carcinoma was misdiagnosed in individuals with darker skin, emphasizing the challenges in accurate diagnosis for this population.
25 citations
,
December 2008 in “Journal of Dermatological Case Reports” This case report describes alopecia areata dermoscopy in an African-American patient, revealing novel patterns such as a diffuse honeycomb-like pigmented network and white dots, suggesting skin color may affect dermoscopic findings.
1 citations
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December 2024 in “Revista Eletrônica Acervo Saúde” This article reviews dermatological research on black skin, emphasizing its unique physiological characteristics and common conditions like acne and eczema, and suggests more focus is needed on its structural differences and clinical responses.
This study identified 92 novel regulators of melanogenesis, highlighting Aldehyde dehydrogenase 1A1 as a potential target for developing new treatments for hyperpigmentation disorders like melasma.
2 citations
,
March 2023 in “Frontiers in Medicine” This case study presented a 16-year-old male with dermatosis neglecta and obsessive-compulsive disorder, where his skin condition improved after proper cleansing and psychiatric treatment, suggesting that DN may also indicate underlying psychiatric issues.
9 citations
,
May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study identifies novel subpopulations of human epidermal melanocytes and specific transcriptional programs that differ from model organisms, providing insights into melanoma dedifferentiation.
31 citations
,
November 2015 in “PloS one” In this study, modulating Tyrosinase expression altered mouse coat color by affecting melanosome accumulation, indicating that melanosome maturity plays a role in determining skin and hair color beyond total melanin content.
8 citations
,
February 2013 in “Central European Journal of Biology” This article discusses melanocyte development from neural crest cells and reports no new experimental results; the authors suggest a broader range of functions for melanocytes than previously recognized.
23 citations
,
January 1964 in “Archives of Dermatology” This report describes a child with ulerythema ophryogenes marked by eyebrow hair absence and progressive skin atrophy, whose condition did not improve despite elevated vitamin A levels via injections.
38 citations
,
June 2005 in “Acta Biochimica Polonica” This study found that spleens of black C57BL/6 mice contain eumelanin, with properties different from skin and hair melanin, and may originate from skin melanin transported by immune cells.
February 2026 in “Case Reports in Dermatology” This study reported two cases of finasteride-induced melasma, suggesting clinicians should consider 5-ARI exposure in patients with new-onset or persistent facial hyperpigmentation, especially in those with darker skin types.
May 2015 in “Journal of Investigative Dermatology” Melanoma risk tools need improvement, a gene mutation causes a hair disorder that might be treated by managing cell stress, a potential therapy for a skin-ear disorder involves blocking cell channels, skin wrinkling may indicate lung aging regardless of smoking, and oxidative stress might contribute to common baldness.
349 citations
,
January 2005 in “The FASEB journal” This review discusses the cutaneous serotoninergic/melatoninergic system's potential role in skin function and resilience against environmental and internal stresses, but does not report new experimental findings.
5 citations
,
January 2018 in “Indian Dermatology Online Journal” This case report describes a strong dermoscopic and histopathological correlation in lichen nitidus, helping differentiate it from other similar conditions.
January 2019 in “DSpace@MIT (Massachusetts Institute of Technology)” This study found that increased PHGDH expression in mice led to earlier melanin and melanocyte presence in hair follicles but did not induce cancer.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that early pigment cell markers Sox10 and c-KIT, as well as DCT/TRP-2, were detectable in melanogenically-active melanocytes of the anagen bulb in human hair follicles.
50 citations
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February 2004 in “Journal of Investigative Dermatology” 27 citations
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January 1995 This study found that higher melanin concentration in black hair offers photoprotection against sunlight-induced protein damage in the cortex, whereas the cuticle experiences similar photodamage regardless of hair pigmentation.
The document concludes that dermatology training and grading scales need to better represent dark-skinned individuals to improve diagnosis and assessment of skin conditions.
October 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that neonatal Regulatory T cells are crucial for maintaining PPARγ signaling in hair follicles, which supports melanocyte stem cell function and skin pigmentation during early postnatal development.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers observed that vitiligo-affected skin shows a selective depletion of NTRK2+ melanocyte subpopulations with progenitor features, which may contribute to poor treatment responses.
8 citations
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January 2017 in “Korean Journal of Physiology and Pharmacology” This study found that pimecrolimus enhances melanin synthesis and promotes melanocyte migration, possibly by increasing MITF protein expression, which may explain its effectiveness in repigmenting vitiligo.