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    Glossary MAPK pathway

    crucial cell signaling mechanism regulating growth, division, and stress response

    The MAPK pathway, or Mitogen-Activated Protein Kinase pathway, is a crucial signaling mechanism in cells that helps regulate various activities such as growth, division, and response to stress. It involves a series of proteins that communicate signals from the cell surface to the DNA in the nucleus, ultimately influencing gene expression and cellular behavior. This pathway is significant in many biological processes and is often studied in the context of diseases like cancer and conditions affecting hair growth, such as alopecia.

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    1. Network Pharmacology Reveals Curcuma aeruginosa Roxb. Regulates MAPK and HIF-1 Pathways to Treat Androgenetic Alopecia Biology · 2024
    2. Hair growth‐promotion effects of different alternating current parameter settings are mediated by the activation of Wnt/<i>β</i>‐catenin and MAPK pathway Experimental Dermatology · 2015 · 27 citations
    3. Melatonin regulates the mitogen-activated protein kinase ( MAPK ) pathway via the circMPP5-miR-211-MAPK3 axis to induce secondary hair follicle differentiation and development in newborn Cashmere goat kids Research Square (Research Square) · 2022 · 1 citations
    4. Camellia sinensis Seed Flavonoids Attenuate UVB-Induced Inflammation and UVA-Induced Photodamage via MAPK/NF-κB and AP-1 Pathways Molecules · 2026
    5. Maternal Melatonin Contributes to Offspring Hair Follicle Development Through Transcriptional Regulation of the AP-1 Complex and MAPK Pathway International Journal of Molecular Sciences · 2025
    6. Synergistic Effects of Fractional CO <sub>2</sub> Laser and Recombinant Humanized Type III Collagen (rhCol III) in Atrophic Acne Scar Treatment: Activation of MAPK Pathway and Enhanced Collagen Remodeling Dermatologic Therapy · 2025
    7. Terminalia bellirica (Gaertn.) Roxb. extracts reshape the perifollicular microenvironment and regulate the MAPK pathway for androgenetic alopecia treatment Journal of Ethnopharmacology · 2024
    8. Inhibition of CISD1 attenuates cisplatin-induced hearing loss in mice via the PI3K and MAPK pathways Biochemical pharmacology · 2024
    9. Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway Molecules · 2020 · 25 citations
    10. Reductive Stress Selectively Disrupts Collagen Homeostasis and Modifies Growth Factor-independent Signaling Through the MAPK/Akt Pathway in Human Dermal Fibroblasts Molecular & cellular proteomics · 2019 · 9 citations
    11. Sinapic Acid Promotes Browning of 3T3‐L1 Adipocytes via p38 MAPK/CREB Pathway BioMed Research International · 2020 · 29 citations
    12. Protective effect of a novel metal-phenolic network composite against ultraviolet-induced skin damage by modulating MAPK/AP-1/NF-κB signaling pathways and attenuating oxidative stress in human keratinocytes Biomedicine & Pharmacotherapy · 2025
    13. 705 Particulate matter induces inflammatory response in human outer root sheath cells via oxidative stress-dependent MAPK and JAK-STAT signaling pathways 2022
    14. Isoalantolactone (ISA) Stimulates Hair Cell Growth Through Activation of the WNT/β-catenin and Ras/MAPK Pathways Korean Journal of Pharmacognosy · 2025
    15. Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways Frontiers in Microbiology · 2021 · 30 citations
    16. PKCδ/MAPKs and NF-κB Pathways are Involved in the Regulation of Ingenane-Type Diterpenoids from Euphorbia neriifolia on Macrophage Function Journal of Inflammation Research · 2021 · 9 citations
    17. Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway Drug Design Development and Therapy · 2025
    18. Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias Medical Science Monitor · 2018 · 10 citations
    19. LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway Stem cell research & therapy · 2016 · 53 citations
    20. Inflammatory memory-activated biomimetic nanovesicles regulate neutrophil plasticity and metabolic reprogramming for rapid diabetic wound healing via targeting miR-193a-5p/TLR4/JNK/P38 MAPK pathways Journal of Nanobiotechnology · 2025 · 9 citations
    21. Anticancer Effects of Broccoli Sprout Extract and Sulforaphane Through ROS-Induced MAPK Pathway in Breast Cancer Cells and Xenografts Antioxidants · 2026
    22. Wedelolactone Attenuates Pulmonary Fibrosis Partly Through Activating AMPK and Regulating Raf-MAPKs Signaling Pathway Frontiers in Pharmacology · 2019 · 58 citations
    23. Multiomics Analysis Reveals Molecular Pathways Associated With the Effects of <i>Pinus massoniana</i> Needles Extract on Androgenetic Alopecia Dermatologic Therapy · 2026
    24. An analysis of gene expression data involving examination of signaling pathways activation reveals new insights into the mechanism of action of minoxidil topical foam in men with androgenetic alopecia Cell Cycle · 2017 · 12 citations
    25. Transcriptomic inspection revealed a possible pathway regulating the formation of the high-quality brush hair in Chinese Haimen goat ( <i>Capra hircus</i> ) Royal Society Open Science · 2018 · 11 citations
    26. Mathematical Modeling and Inference of Epidermal Growth Factor-Induced Mitogen-Activated Protein Kinase Cell Signaling Pathways International Journal of Molecular Sciences · 2024 · 3 citations
    27. Identification of key pathways and genes that regulate cashmere development in cashmere goats mediated by exogenous melatonin Frontiers in veterinary science · 2022 · 3 citations
    28. The AR/miR-221/IGF-1 pathway mediates the pathogenesis of androgenetic alopecia International Journal of Biological Sciences · 2023 · 2 citations
    29. Exploring the Complexities of TGF-beta Signaling in Keloids: Beyond the Classical Smad Pathway International Journal of Molecular Sciences · 2026
    30. Ar/miR-221/IGF-1 Pathway Mediates the Pathogenesis of Androgenetic Alopecia Social Science Research Network · 2022