63 citations
,
December 1998 in “Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology” The study improved understanding of keratin fiber structure by showing consistent microfibril diameter but varying distances and electron density profiles.
55 citations
,
February 2014 in “Journal of Structural Biology” This study observed that human hair macrofibrils predominantly exhibit a double-twist architecture with varying inter-macrofibril angles, advancing insights into their structural organization and mechanical implications.
24 citations
,
June 2003 in “Journal of Structural Biology” This study suggests that varying intersheet interactions may explain the differences between the two polymorphic forms of macrofibril assembly in Merino wool and hair.
9 citations
,
April 2019 in “Journal of Structural Biology” Keratin fibers in hair twist left-handed.
6 citations
,
January 2018 in “Advances in experimental medicine and biology” 15 citations
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December 2013 in “Clinical Cosmetic and Investigational Dermatology” This study found that levels of the protein MAGP-1, important for skin elasticity, decrease with aging and photoexposure, potentially contributing to skin fragility, sagging, and enlarged pores.
2 citations
,
August 1987 in “Analytical Biochemistry” This study introduced a method to isolate and separate microfibrillar proteins from human hair, identifying previously undetected glycine- and tyrosine-rich proteins.
June 2022 in “International Journal of Research in Dermatology” This study found that injectable platelet-rich fibrin significantly improved hair growth and patient satisfaction as a cost-effective adjuvant treatment for androgenetic alopecia.
49 citations
,
June 2004 in “Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences” This study developed a multiscale model to understand human hair fiber mechanics and found that the yield stress decreases linearly with temperature, supported by both simulations and experimental stretching of hair fibers.
45 citations
,
December 2006 in “Biopolymers” This study found that permanent waving treatment induces structural changes in the cortex proteins of white human hair, significantly reducing its tensile strength without altering the S-S band intensity.
18 citations
,
March 2009 in “Skin pharmacology and physiology” This study found that sunlight exposure causes significant structural and chemical damage to hair, including cuticle loss, cortex damage, and discoloration, with water playing a major role in discoloration of brown hair.
12 citations
,
January 2014 in “Cell structure and function” This study suggests that specific combinations of human type I and II hair keratins, particularly K35-K85 and K36-K81, have distinct in vitro assembly properties that are significant for macrofibril formation.
4 citations
,
July 2010 in “International Journal of Cosmetic Science” This study observed that hair fibers in older women become more curved with age, decreasing hair luster due to their disordered alignment and structural differences between the convex and concave sides.
4 citations
,
January 1981 in “PubMed” This study found that medullary cell content in mammal hair evolves from an amorphous form to a biphasic phase, with human and anthropoid hair containing both macrofibrils and microfibrils.
January 2009 in “Nihon Keshouhin Gijutsushakaishi/Journal of S C C./Nihon Keshouhin Gijutsushakai kaishi” This study found that the structural and chemical composition of human curly hair may resemble that of sheep wool, implying a shared characteristic among mammals with wavy hair.
85 citations
,
October 2007 in “International Journal of Dermatology” In this study, researchers found that the curliness of human hair is associated with an asymmetric structure at the cellular level, particularly in the differentiation of the precortex.
70 citations
,
June 1998 in “Polymer” This study found that permanent waving treatment partially disrupts the α-helical structure in human hair microfibrils, primarily during the initial reduction phase, rather than just affecting disulphide bonds.
30 citations
,
April 2009 in “Mycoses” This study found that the fungus Microsporum gypseum enzymatically degrades keratin in human hair, with the sequence of degradation reflecting the keratinization and cystine content of individual hair components in vitro.
19 citations
,
January 2009 in “International review of cell and molecular biology” This review explains the mechanical composition and molecular interactions that determine hair's mechanical properties, without providing any new experimental findings.
6 citations
,
January 2005 in “Han-guk hyeonmigyeong hakoeji/Applied microscopy” This study found that the 16th-century mummified hair from a female mummy in Paju was remarkably well-preserved, with the hair's ultrastructural features maintained likely due to a calcium-rich surface coat.
4 citations
,
April 2019 in “Cosmetics” In this study, the bending stiffness of human hair was linked to the varying proportions of para-like versus ortho-like cortical cells within the hair fiber.
3 citations
,
January 1998 in “ACTA HISTOCHEMICA ET CYTOCHEMICA” This study used rapid-freezing immunocytochemistry to successfully map the ultrastructural localization of hair keratins in human scalp hair, primarily finding them in macrofibrils in the cortex and endocuticle.
1 citations
,
June 2023 in “Journal of applied crystallography” This study utilized the DNP–SANS technique on human hair for the first time and found significant changes in the SANS profile dependent on polarization conditions, providing insights into the structural composition and dynamic properties of keratin and its associated proteins.
1 citations
,
August 2015 in “PubMed” This study discovered previously unknown structures in human hair shafts that may stabilize hair structurally and physicochemically.
November 2024 in “Biophysical Chemistry” This study analyzed the swelling behavior of human hair during permanent waving treatment, finding that both the microstructure and macrostructure of intermediate filaments swell simultaneously at the initial stage, and while partially destructed by reduction, they are considerably restored through oxidation.
July 2016 in “Indian journal of science and technology” In this study, researchers found that neonate hairs have a distinct microstructure with no medulla and smaller hair follicles compared to adult hairs.
January 2013 in “Sen'i Gakkaishi” This study found that microfibrils play a crucial role in shaping permanent waves by thioglycolic acid, and treating damaged hair with hydrolyzed keratin improved both waving efficiency and hair damage.
This study found that the hair of a 16th-century female mummy discovered in Paju was remarkably well-preserved due primarily to a calcium-based surface coating that likely inhibited moisture and microorganism infiltration.
191 citations
,
November 1959 in “Annals of the New York Academy of Sciences” This article reports electron microscope studies on the structure of hair and wool, but it does not present new clinical findings.
21 citations
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June 2002 in “International Journal of Cosmetic Science” Advancements in hair keratin research could lead to better hair health treatments.