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Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Dihydrotestosterone changes some hormone-related gene expressions in rat pituitary glands but doesn't affect the estrous cycle.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.

The document suggests that targeting the hormone DHT could be a more effective treatment for prostate cancer than targeting testosterone.

Menopause significantly reduces skin collagen, leading to thinner, less elastic skin, and hormone replacement may help but requires careful consideration.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Hormone imbalances can cause skin diseases, and understanding these links is important for diagnosis and treatment.

Flutamide and a new synthetic steroid affected brain and prostate chemicals and showed potential for treating androgen-related conditions and epilepsy.

5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Hormones, especially androgens, play a big role in acne, but most acne sufferers don't have a hormone disorder. Hormonal treatments, including birth control pills, can be very effective for women whose acne doesn't improve with regular treatments.

Plant roots respond to fungus smells by possibly using certain proteins and a plant hormone to change root growth, but more research is needed.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

The document concludes that better biomarkers are needed to detect long-term oral testosterone use in athletes.

The document explains how the male reproductive system works, its role in making testosterone, and how conditions like obesity can disrupt it, leading to low testosterone and fertility issues.

The new test can measure very small amounts of testosterone in hair, and grinding the hair up first gives more accurate results.

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

Using neurohormones to control keratin can lead to new skin disease treatments.

The document concludes that low-dose oral contraceptives and hormonal therapies can manage perimenopause symptoms and reduce some health risks, but lifestyle changes and disease screening are also important.

Prostate-specific antigen may be a new marker for excess male hormones in women with polycystic ovary syndrome.