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The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Understanding where cancer cells come from helps create better prevention and treatment methods.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The Rotterdam Study aims to understand various diseases in older adults.

5% and 2% minoxidil solutions effectively promote hair growth and reduce hair loss, with 5% being slightly more effective but having more side effects.

Mice lacking the PPARγ gene in their fat cells had almost no fat tissue, severe metabolic problems, and abnormal development of other fat-related tissues.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Artificial skin development has challenges, but new materials and understanding cell behavior could improve tissue repair. Also, certain growth factors and hydrogel technology show promise for advanced skin replacement therapies.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Targeted cancer therapies often cause serious skin problems that need careful management.

Essential oils in cosmetics can offer benefits but may cause allergies and should be used carefully.

Spironolactone is a safe and effective treatment for reducing excessive hair growth in women.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.

New effective scar treatments are urgently needed due to the current options' limited success.

Hormone treatments in transsexual individuals reduce hair growth and oil production in male-to-females and increase them in female-to-males.

Some skin medications are safe during pregnancy and breastfeeding, but others can harm the baby and should be avoided.

Omeprazole effectively treats severe acid reflux in children for short-term use, but long-term safety needs more research.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Androgens can cause hair growth in some areas and hair loss on the scalp.

Lichen planus is a skin condition that can resolve on its own, is linked to hepatitis C, and increases the risk of skin cancer.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Liposomal systems show promise for delivering drugs through the skin but face challenges like high costs and stability issues.

The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.