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    Glossary Ligands

    molecules that bind to specific sites on proteins

    Ligands are molecules that bind to specific sites on a target protein, often a receptor, to form a complex. This binding can trigger various biological responses, such as activating or inhibiting a receptor's function. In the context of hair biology, ligands can interact with receptors on hair follicle cells to influence hair growth and health.

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    Research 30 of 1000+

    1. Ligand‐independent epidermal growth factor receptor hyperactivation increases sebaceous gland size and sebum secretion in mice Experimental Dermatology · 2013 · 22 citations
    2. Ligand‐Independent Actions of the Vitamin D Receptor: More Questions Than Answers JBMR plus · 2021 · 11 citations
    3. High-resolution structures of mutants of residues that affect access to the ligand-binding cavity of human lipocalin-type prostaglandin D synthase Acta Crystallographica Section D-biological Crystallography · 2014 · 5 citations
    4. Crystallization and preliminary X-ray analysis of the human androgen receptor ligand-binding domain with a coactivator-like peptide and selective androgen receptor modulators Acta crystallographica · 2008 · 1 citations
    5. Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin International Journal of Molecular Sciences · 2025
    6. Ligand-Independent Vitamin D Receptor Actions Essential for Keratinocyte Homeostasis in the Skin 2024
    7. Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats Cells · 2023
    8. Ligand-Independent Actions of the Vitamin D Receptor Maintain Hair Follicle Homeostasis Molecular Endocrinology · 2004 · 144 citations
    9. A Novel Point Mutation in the Ligand-Binding Domain (LBD) of the Human Glucocorticoid Receptor (hGR) Causing Generalized Glucocorticoid Resistance: The Importance of the C Terminus of hGR LBD in Conferring Transactivational Activity The Journal of Clinical Endocrinology & Metabolism · 2005 · 91 citations
    10. Ligand-Dependent Actions of the Vitamin D Receptor Are Required for Activation of TGF-β Signaling during the Inflammatory Response to Cutaneous Injury Endocrinology · 2012 · 56 citations
    11. A Girl with a Novel Splice Site Mutation in <i>VDR</i> Supports the Role of a Ligand-Independent VDR Function on Hair Cycling Hormone Research in Paediatrics · 2006 · 21 citations
    12. Presence of a Deletion Mutation (c.716delA) in the Ligand Binding Domain of the Vitamin D Receptor in an Indian Patient with Vitamin D-Dependent Rickets Type II Calcified tissue international · 2009 · 18 citations
    13. Ligand‐independent Regulation of the hairless Promoter by Vitamin D Receptor<sup>†</sup> Photochemistry and photobiology · 2008 · 10 citations
    14. Ligand Based 3D-QSAR Study on a Series of Steroidal Human 5&#945;-Reductase Inhibitors Letters in Drug Design & Discovery · 2010 · 3 citations
    15. Ligand-Independent Actions of Vitamin D Receptor Elsevier eBooks · 2017
    16. 1448 Ligand-dependent Wnt signaling attenuates mechanotransduction and protects against wound occlusion-mediated abolishment of hair follicle regeneration Journal of Investigative Dermatology · 2023
    17. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    18. Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration Journal of Investigative Dermatology · 2012 · 170 citations
    19. Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis Journal of Investigative Dermatology · 2007 · 78 citations
    20. Localisation of members of the notch system and the differentiation of vibrissa hair follicles: Receptors, ligands, and fringe modulators Developmental dynamics · 2000 · 62 citations
    21. <i>In Vitro</i>and<i>in Vivo</i>Structure-Activity Relationships of Novel Androgen Receptor Ligands with Multiple Substituents in the B-Ring Endocrinology · 2005 · 20 citations
    22. CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth Biochemical Journal · 2016 · 15 citations
    23. Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching 2015 · 7 citations
    24. TSPO ligand etifoxine attenuates LPS-induced cognitive dysfunction in mice Brain Research Bulletin · 2020 · 5 citations
    25. Development of radioiodinated nonsteroidal androgen receptor ligands for spect imaging of prostate cancer Journal of Labelled Compounds and Radiopharmaceuticals · 2001 · 1 citations
    26. Investigating the role of notch ligands regulating epidermal stem cell differentiation eScholarship@McGill (McGill) · 2025
    27. 616 Endoplasmic reticulum stress upregulates NKG2D ligands in the hair follicle 2017
    28. 693 Dermal papilla-derived Wnt ligands are required for adult hair follicle growth Journal of Investigative Dermatology · 2016
    29. Faculty Opinions recommendation of Epithelial Wnt ligand secretion is required for adult hair follicle growth and regeneration. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    30. Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins Molecular biology of the cell · 2016 · 25 citations