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    Glossary Leucine-rich repeats and immunoglobulin-like domains protein 1

    protein regulating cell growth and maintaining stem cells

    Leucine-rich repeats and immunoglobulin-like domains protein 1 (Lrig1) is a protein that plays a crucial role in regulating cell growth and maintaining stem cell populations in various tissues, including the skin and hair follicles. It acts as a tumor suppressor and helps control the signaling pathways that can lead to cell proliferation, making it important for both normal tissue maintenance and cancer prevention.

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    Research 30 of 744

    1. 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis Journal of Investigative Dermatology · 2017
    2. New small molecules in dermatology: for the autoimmunity, inflammation and beyond Inflammation Research · 2023 · 9 citations
    3. Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing Frontiers in Medicine · 2022 · 5 citations
    4. Targeted protein degradation of Wnt/β-catenin signaling pathway: an effective strategy for cancer therapy Journal of Translational Medicine · 2025 · 8 citations
    5. 1371 FGF7-dependent inhibition of human hair growth byan osteopontin-derived peptide: A novel solution for hirsutism and hypertrichosis? Journal of Investigative Dermatology · 2018
    6. 1375 Cutaneous adnexal cysts revisited: A novel classification based on morphological and molecular features Journal of Investigative Dermatology · 2018
    7. S100A6: molecular function and biomarker role Biomarker Research · 2023 · 50 citations
    8. Expanding the Scope of PROTACs: Opportunities and Challenges in Topical Delivery Journal of Medicinal Chemistry · 2025
    9. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    10. Function of KLF4 in Stem Cell Biology InTech eBooks · 2013 · 5 citations
    11. The role of versican in the skin ECM and its interaction with hyaluronic acid Biomecánica · 2019 · 2 citations
    12. Mechanisms regulating skin immunity and inflammation Nature Reviews Immunology · 2014 · 610 citations
    13. Follicular Neutrophilic Inflammation (Hidradenitis Suppurativa) Springer eBooks · 2018
    14. Comparative Transcriptome Analysis of Fetal Skin Reveals Key Genes Related to Hair Follicle Morphogenesis in Cashmere Goats PLoS ONE · 2016 · 127 citations
    15. In silico analysis of gene expression data from bald frontal and haired occipital scalp to identify candidate genes in male androgenetic alopecia Archives of Dermatological Research · 2019 · 6 citations
    16. A practical guide for the study of human and murine sebaceous glands <i>in situ</i> Experimental Dermatology · 2013 · 56 citations
    17. Wound Healing: A Cellular Perspective Physiological Reviews · 2018 · 1160 citations
    18. What does acne genetics teach us about disease pathogenesis? British Journal of Dermatology · 2019 · 29 citations
    19. New insights into inflammatory memory of epidermal stem cells Frontiers in immunology · 2023 · 2 citations
    20. Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways Scientific Reports · 2026
    21. The Immunological Impact of IL-1 Family Cytokines on the Epidermal Barrier Frontiers in Immunology · 2021 · 23 citations
    22. Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing PLOS ONE · 2012 · 23 citations
    23. LGR5 is a Marker of Poor Prognosis in Glioblastoma and is Required for Survival of Brain Cancer Stem‐Like Cells Brain pathology · 2012 · 82 citations
    24. Cellular Plasticity in Cutaneous Wound Healing Biomedical Journal of Scientific & Technical Research · 2018
    25. Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization Stem Cell Research & Therapy · 2020 · 65 citations
    26. Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia Journal of The American Academy of Dermatology · 2018 · 25 citations
    27. Specific In Vivo Ablation of Lrig1-Positive Follicular Progenitor Cells Results in Sebaceous Gland Loss in Mice International Journal of Molecular Sciences · 2026
    28. The Potential Reversible Transition between Stem Cells and Transient-Amplifying Cells: The Limbal Epithelial Stem Cell Perspective Cells · 2024 · 1 citations
    29. Dermal white adipose tissue: Development and impact on hair follicles, skin defense, and fibrosis The FASEB Journal · 2024 · 3 citations
    30. Genome-wide meta-analysis identifies novel loci conferring risk of acne vulgaris European Journal of Human Genetics · 2023 · 29 citations