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    Glossary Keratinocyte Growth Factor

    stimulates skin and hair cell growth and repair

    Keratinocyte Growth Factor (KGF), also known as Fibroblast Growth Factor 7 (FGF-7), is a protein that plays a crucial role in the growth and repair of skin and hair. It specifically stimulates the proliferation and differentiation of keratinocytes, which are the primary cells found in the outer layer of the skin and hair follicles. This makes KGF important in wound healing and potentially beneficial in treating conditions like alopecia.

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    1. Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice. The EMBO Journal · 1993 · 265 citations
    2. Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. PubMed · 1995 · 219 citations
    3. Expression and Function of Keratinocyte Growth Factor and Activin in Skin Morphogenesis and Cutaneous Wound Repair 2000 · 113 citations
    4. Specific receptor detection by a functional keratinocyte growth factor-immunoglobulin chimera. 1995 · 66 citations
    5. Strengthening the Skin with Topical Delivery of Keratinocyte Growth Factor-1 Using a Novel DNA Plasmid Molecular Therapy · 2014 · 23 citations
    6. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts Journal of dermatological science · 2019 · 20 citations
    7. Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes Plastic and Reconstructive Surgery · 2007 · 16 citations
    8. Keratinocyte Growth Factor Modified Messenger RNA Accelerating Cell Proliferation and Migration of Keratinocytes Nucleic Acid Therapeutics · 2018 · 11 citations
    9. Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model Frontiers in Medicine · 2025 · 8 citations
    10. Production of a 135-residue long N-truncated human keratinocyte growth factor 1 in Escherichia coli Microbial Cell Factories · 2023 · 5 citations
    11. Expression and Cellular Localization of Keratinocyte Growth Factor and Its Receptor in Human Hyperplastic Prostate Tissue<sup>1</sup> The Journal of Clinical Endocrinology & Metabolism · 1998 · 4 citations
    12. Production of a 135-residue long N-truncated human keratinocyte growth factor 1 in Escherichia coli Research Square (Research Square) · 2022 · 2 citations
    13. A Nonrandomized Clinical Trial Investigating Keratinocyte Growth Factor‐Hair Serum for the Prevention of Chemotherapy‐Induced Alopecia Journal of Cosmetic Dermatology · 2026
    14. Interleukin-1 and Keratinocyte Growth Factor/Fibroblast Growth Factor-7 Gene Expression in Skin Experimental Irritant Contact Dermatitis Mouse Model Treated with Aqueous Extract of Trachyspermum copticum (L.) Link Seeds 2018
    15. Research progress and strategies for the biosynthesis of keratinocyte growth factor-2 (KGF-2) in <i>Arabidopsis thaliana</i> PeerJ · 2025
    16. Effects of recombinant human keratinocyte growth factor-2 on hair regeneration in experimental bald rats 2012
    17. Recent advances in the epidermal growth factor receptor/ligand system biology on skin homeostasis and keratinocyte stem cell regulation Journal of Dermatological Science · 2013 · 97 citations
    18. Differential effects of caffeine on hair shaft elongation, matrix and outer root sheath keratinocyte proliferation, and transforming growth factor‐β2/insulin‐like growth factor‐1‐mediated regulation of the hair cycle in male and female human hair follicles<i>in vitro</i> British Journal of Dermatology · 2014 · 60 citations
    19. trans-3,4'-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor .BETA.2 (TGF-.BETA.2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes Biological and Pharmaceutical Bulletin · 2008 · 10 citations
    20. 854 Dermal fibroblasts enhance growth factors production by androgens, and modulate keratinocyte proliferation and differentiation 2018
    21. Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes Molecular and Cellular Biology · 2006 · 226 citations
    22. Growth factor mimetics for skin regeneration: In vitro profiling of primary human fibroblasts and keratinocytes Archiv der Pharmazie · 2021 · 3 citations
    23. An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes British Journal of Dermatology · 2019 · 19 citations
    24. N,N-Dimethylglycine Sodium Salt Exerts Marked Anti-Inflammatory Effects in Various Dermatitis Models and Activates Human Epidermal Keratinocytes by Increasing Proliferation, Migration, and Growth Factor Release International Journal of Molecular Sciences · 2023
    25. 692 Study of the impact of SKPs’ secreted factors and of a botanical extract derived from jasmine on keratinocytes growth and reconstructed human epidermis thickness Journal of Investigative Dermatology · 2016
    26. GROWTH FACTORS IN HAIR ORGAN DEVELOPMENT AND THE HAIR GROWTH CYCLE Dermatologic Clinics · 1996 · 90 citations
    27. Hair growth induction by the tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras‐dependent up‐regulation of KGF expression The FASEB Journal · 2003 · 51 citations
    28. The essential oils of Chamaecyparis obtusa promote hair growth through the induction of vascular endothelial growth factor gene Fitoterapia · 2009 · 49 citations
    29. Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed 2021 · 17 citations
    30. Nonanal Stimulates Growth Factors via Cyclic Adenosine Monophosphate (cAMP) Signaling in Human Hair Follicle Dermal Papilla Cells International Journal of Molecular Sciences · 2020 · 8 citations