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    Glossary Interleukin-36

    group of cytokines involved in immune system signaling and inflammation

    Interleukin-36 (IL-36) is a group of cytokines, which are small proteins important for cell signaling in the immune system. These cytokines play a crucial role in inflammatory responses and are involved in the pathogenesis of various autoimmune and inflammatory diseases, such as psoriasis. IL-36 includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra), which together help regulate the body's immune response.

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    1. Interleukin-36 role in the severity of acne vulgaris: A case control study Research Square · 2026
    2. IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation Frontiers in Cell and Developmental Biology · 2020 · 7 citations
    3. Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair Nature Communications · 2016 · 86 citations
    4. Topical olive oil with downregulation of stress factors protects mice skin from precarious 3600 MHz electromagnetic radiation. The Egyptian Journal of Histology · 2020
    5. Hidradenitis Suppurativa as a Potential Subtype of Autoinflammatory Keratinization Disease Frontiers in immunology · 2020 · 41 citations
    6. Docosahexaenoic acid slows inflammation resolution and impairs the quality of healed skin tissue Clinical Science · 2019 · 8 citations
    7. Particulate matter exposure induces maternal scalp hair loss after birth in C57/B6 mouse via alteration of inflammatory and apoptotic pathways Frontiers in Endocrinology · 2026
    8. Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils 2020 · 16 citations
    9. Predominant expression of interleukin (IL)‐17 in chronic alopecia areata compared to IFN‐γ in pathogenic Th17 cells, tissue‐resident memory T cells and natural killer cells JEADV Clinical Practice · 2023 · 3 citations
    10. Increased serum interleukin-17A levels correlate with disease severity and poor prognostic factors in patients with alopecia areata Dermatology Reports · 2021
    11. Dermatologic Changes Associated With Interleukin 2 Administration JAMA · 1987 · 123 citations
    12. Effect of diode pumping solid state laser with wavelength 589 nm on gene expression of interlukine-2 and interferon-gamma Lowercase in human T-lymphocytes Journal of the Pakistan Medical Association · 2024
    13. Dupilumab in Inflammatory Skin Diseases: A Systematic Review Biomolecules · 2023 · 72 citations
    14. ACTH as first line treatment for acute calcium pyrophosphate crystal arthritis in 14 hospitalized patients Joint Bone Spine · 2013 · 14 citations
    15. Evaluation of platelet-rich plasma on hair regrowth and lesional T-cell cytokine expression in alopecia areata: A randomized observer-blinded, placebo-controlled, split-head pilot study Journal of The American Academy of Dermatology · 2020 · 9 citations
    16. Photoprotective and immunoregulatory capacity of ginsenoside Rg1 in chronic ultraviolet B-irradiated BALB/c mouse skin Experimental and Therapeutic Medicine · 2013 · 6 citations
    17. Author response: Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells 2017
    18. Comparative Study of Some Potential Paracrine Factors Produced by Normal and Androgenetic Alopecia Hair Follicles American journal of medical and biological research · 2015
    19. Dissecting Cellulitis of the Scalp: Linking Pathogenesis to Therapy Biomedicines · 2026
    20. DISRUPTION OF HAIR FOLLICLE IMMUNE PRIVILEGE IN ALOPECIA AREATA: ENIGMATIC MECHANISMS AND EMERGING CONCEPTS Academic Medical Journal · 2025
    21. Impaired responses of peripheral blood mononuclear cells to T-cell stimulants in alopecia areata patients with a poor response to topical immunotherapy 2008 · 4 citations
    22. WNT5A drives interleukin-6-dependent epithelial–mesenchymal transition via the JAK/STAT pathway in keloid pathogenesis Burns & Trauma · 2022 · 56 citations
    23. Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice Inflammation and Regeneration · 2023 · 7 citations
    24. Assessment of Interleukin-17A and Interleukin-2 Serum Levels in Patients with Alopecia Areata Kufa Medical journal · 2024
    25. Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling Biomolecules · 2022 · 13 citations
    26. Innate type 2 immunity controls hair follicle commensalism by Demodex mites Immunity · 2022 · 24 citations
    27. Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5α-Reductase Inhibitory, Anti-Inflammatory, and In Vivo Anti-Hair Loss Effects Pharmaceuticals · 2022 · 7 citations
    28. Anagen hair follicles transplanted into mature human scars remodel fibrotic tissue npj regenerative medicine · 2023 · 6 citations
    29. Mechanisms of magnesium oxide‐incorporated electrospun membrane modulating inflammation and accelerating wound healing Journal of Biomedical Materials Research Part A · 2022 · 4 citations
    30. Lactobacillus paracasei HY7015 and Lycopus lucidus Turcz. Extract Promotes Human Dermal Papilla Cell Cytoprotective Effect and Hair Regrowth Rate in C57BL/6 Mice 2022 · 3 citations