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    Glossary Interleukin-1 Receptor Antagonist

    naturally occurring protein that inhibits inflammatory molecule interleukin-1

    Interleukin-1 Receptor Antagonist (IL-1RA) is a naturally occurring protein that inhibits the activity of interleukin-1 (IL-1), a molecule involved in inflammatory responses. By blocking IL-1 from binding to its receptor, IL-1RA helps reduce inflammation and is used in treatments for conditions like rheumatoid arthritis and other inflammatory diseases.

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    1. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    2. Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice 2023
    3. Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice 2023
    4. Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling? Journal of Cellular Physiology · 2008 · 19 citations
    5. IL-1 alpha inhibits human hair follicle growth and hair fiber production in whole-organ cultures. PubMed · 1993 · 30 citations
    6. Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture 2014 · 15 citations
    7. THE PATHOGENESIS OF ALOPECIA AREATA Dermatologic Clinics · 1996 · 89 citations
    8. FOLLICULAR LIPOSOMAL DELIVERY SYSTEMS Journal of liposome research · 2002 · 55 citations
    9. Alopecia Areata: An Overview of the Disease and its Genetic Basis: Review Article The Egyptian Journal of Hospital Medicine · 2022 · 1 citations
    10. 557 A peptide derivative with known anti-wrinkle properties was identified as potent dipeptiylpeptidase-4 inhibitor Journal of Investigative Dermatology · 2016
    11. Dupilumab for the treatment of alopecia areata in children with atopic dermatitis JAAD case reports · 2021 · 7 citations
    12. 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes Journal of Investigative Dermatology · 2003 · 56 citations
    13. Improvement of atopic dermatitis and alopecia universalis with dupilumab: a case report Dermatology reports · 2021 · 3 citations
    14. Emerging Therapies for Acne Vulgaris American Journal of Clinical Dermatology · 2018 · 22 citations
    15. Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes Acta dermato-venereologica · 2018 · 9 citations
    16. Androgen Receptor Inhibitors in the Treatment of Acne Vulgaris: Efficacy and Safety Profiles of Clascoterone 1% Cream Clinical Cosmetic and Investigational Dermatology · 2022 · 4 citations
    17. Skin, eye and other problems Journal of the European Academy of Dermatology and Venereology · 2019
    18. New treatments for rheumatoid arthritis Postgraduate Medicine · 1999 · 13 citations
    19. Drug News ​​​​​​​​​​​​​​Nursing2023 · 2017
    20. Drug Repurposing Patent Applications April–June 2021 Assay and drug development technologies · 2021
    21. The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5‐Independent Manner Experimental Dermatology · 2025
    22. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    23. Cytostatics and immunosuppressive drugs Side effects of drugs annual · 1989
    24. Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist Expert opinion on pharmacotherapy · 2021 · 9 citations
    25. Recent approaches of antibody therapeutics in androgenetic alopecia Frontiers in Pharmacology · 2024
    26. Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology Hair transplant forum international · 2012 · 1 citations
    27. The itchy scalp - scratching for an explanation Experimental dermatology · 2011 · 61 citations
    28. Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers Annals of Dermatology · 2011 · 3 citations
    29. Scarless wound healing: finding the right cells and signals Cell and Tissue Research · 2016 · 132 citations
    30. Advances in molecular pathogenesis of hidradenitis suppurativa: Dysregulated keratins and ECM signaling Seminars in cell & developmental biology · 2022 · 5 citations