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    Did you mean Interleukin-1 Receptor Antagonist?
    Glossary Interleukin-1 Receptor Antagonist

    naturally occurring protein that inhibits inflammatory molecule interleukin-1

    Interleukin-1 Receptor Antagonist (IL-1RA) is a naturally occurring protein that inhibits the activity of interleukin-1 (IL-1), a molecule involved in inflammatory responses. By blocking IL-1 from binding to its receptor, IL-1RA helps reduce inflammation and is used in treatments for conditions like rheumatoid arthritis and other inflammatory diseases.

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    1. FOLLICULAR LIPOSOMAL DELIVERY SYSTEMS Journal of liposome research · 2002 · 55 citations
    2. 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes Journal of Investigative Dermatology · 2003 · 56 citations
    3. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    4. Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling? Journal of Cellular Physiology · 2008 · 19 citations
    5. IL-1 alpha inhibits human hair follicle growth and hair fiber production in whole-organ cultures. PubMed · 1993 · 30 citations
    6. Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle Experimental Dermatology · 2021 · 14 citations
    7. New treatments for rheumatoid arthritis Postgraduate Medicine · 1999 · 13 citations
    8. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    9. Emerging Therapies for Acne Vulgaris American Journal of Clinical Dermatology · 2018 · 22 citations
    10. GPCRs as key regulators in wound healing Frontiers in Cell and Developmental Biology · 2026
    11. 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis Journal of Investigative Dermatology · 2017
    12. Molecular biology of hair morphogenesis: Development and cycling Journal Of Experimental Zoology Part B: Molecular And Developmental Evolution · 2003 · 155 citations
    13. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    14. Androgens and acne: perspectives on clascoterone, the first topical androgen receptor antagonist Expert opinion on pharmacotherapy · 2021 · 9 citations
    15. The Transcriptional Co-Activator cAMP Response Element-Binding Protein-Binding Protein Is Expressed in Prostate Cancer and Enhances Androgen- and Anti-Androgen-Induced Androgen Receptor Function American Journal of Pathology · 2003 · 72 citations
    16. Baiting Proteins with C<sub>60</sub> ACS Nano · 2010 · 106 citations
    17. Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes Acta dermato-venereologica · 2018 · 9 citations
    18. The itchy scalp - scratching for an explanation Experimental dermatology · 2011 · 61 citations
    19. Injury-induced interleukin-1 alpha promotes Lgr5 hair follicle stem cells de novo regeneration and proliferation via regulating regenerative microenvironment in mice Inflammation and Regeneration · 2023 · 7 citations
    20. The Role of gp91phox and the Effect of Tranexamic Acid Administration on Hair Color in Mice International Journal of Molecular Sciences · 2019 · 2 citations
    21. Recent approaches of antibody therapeutics in androgenetic alopecia Frontiers in Pharmacology · 2024
    22. Inflammation in androgenetic alopecia and hair loss: linking neurosciences-endocrinology-dermatology Hair transplant forum international · 2012 · 1 citations
    23. Treatment of Cultured Sebocytes with an EGFR Inhibitor Does Not Lead to Significant Upregulation of Inflammatory Biomarkers Annals of Dermatology · 2011 · 3 citations
    24. Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone Frontiers in pharmacology · 2023
    25. Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin International journal of molecular sciences · 2024
    26. Advances in molecular pathogenesis of hidradenitis suppurativa: Dysregulated keratins and ECM signaling Seminars in cell & developmental biology · 2022 · 5 citations
    27. Hair Growth Effect and the Mechanisms of Rosa rugosa Extract in DHT-Induced Alopecia Mice Model International Journal of Molecular Sciences · 2024
    28. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    29. RAGE and Its Ligands in Melanoma InTech eBooks · 2015 · 1 citations
    30. The Effect of Parathyroid Hormones on Hair Follicle Physiology: Implications for Treatment of Chemotherapy-Induced Alopecia Skin Pharmacology and Physiology · 2015 · 15 citations