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    Did you mean Interleukin-1 Receptor Antagonist?
    Glossary Interleukin-1 Receptor Antagonist

    naturally occurring protein that inhibits inflammatory molecule interleukin-1

    Interleukin-1 Receptor Antagonist (IL-1RA) is a naturally occurring protein that inhibits the activity of interleukin-1 (IL-1), a molecule involved in inflammatory responses. By blocking IL-1 from binding to its receptor, IL-1RA helps reduce inflammation and is used in treatments for conditions like rheumatoid arthritis and other inflammatory diseases.

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    1. Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice Cancer Research · 2009 · 53 citations
    2. Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice 2023
    3. Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice 2023
    4. Skin toxicity caused by EGFR antagonists—An autoinflammatory condition triggered by deregulated IL‐1 signaling? Journal of Cellular Physiology · 2008 · 19 citations
    5. Erlotinib-Induced Skin Inflammation Is IL-1 Mediated in KC-Tie2 Mice and Human Skin Organ Culture 2014 · 15 citations
    6. IL-1 alpha inhibits human hair follicle growth and hair fiber production in whole-organ cultures. PubMed · 1993 · 30 citations
    7. The TRPM5 Antagonist Triphenylphosphine Oxide Increases Sebaceous Lipogenesis and Modulates Immune Phenotype of Human Sebocytes in a TRPM5‐Independent Manner Experimental Dermatology · 2025
    8. 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes Journal of Investigative Dermatology · 2003 · 56 citations
    9. THE PATHOGENESIS OF ALOPECIA AREATA Dermatologic Clinics · 1996 · 89 citations
    10. FOLLICULAR LIPOSOMAL DELIVERY SYSTEMS Journal of liposome research · 2002 · 55 citations
    11. Alopecia Areata: An Overview of the Disease and its Genetic Basis: Review Article The Egyptian Journal of Hospital Medicine · 2022 · 1 citations
    12. 557 A peptide derivative with known anti-wrinkle properties was identified as potent dipeptiylpeptidase-4 inhibitor Journal of Investigative Dermatology · 2016
    13. Scarless wound healing: finding the right cells and signals Cell and Tissue Research · 2016 · 132 citations
    14. Cytostatics and immunosuppressive drugs Side effects of drugs annual · 1989
    15. ACTH as first line treatment for acute calcium pyrophosphate crystal arthritis in 14 hospitalized patients Joint Bone Spine · 2013 · 14 citations
    16. Hair-cycle changes in two patients taking tocilizumab Joint Bone Spine · 2013 · 6 citations
    17. Dupilumab for the treatment of alopecia areata in children with atopic dermatitis JAAD case reports · 2021 · 7 citations
    18. Emerging Therapies for Acne Vulgaris American Journal of Clinical Dermatology · 2018 · 22 citations
    19. Improvement of atopic dermatitis and alopecia universalis with dupilumab: a case report Dermatology reports · 2021 · 3 citations
    20. Allopregnanolone (AP) induces opioid inhibition of hypothalamo-pituitary-adrenal (HPA) axis responses to interleukin-1β (IL-1β) in pregnancy Experimental and Clinical Endocrinology & Diabetes · 2005 · 1 citations
    21. Central Opioid Inhibition of Neuroendocrine Stress Responses in Pregnancy in the Rat Is Induced by the Neurosteroid Allopregnanolone Journal of Neuroscience · 2009 · 123 citations
    22. From Bald to Bold: Reversal of Alopecia Totalis in an Adolescent Using Dupilumab Monotherapy Journal of Drugs in Dermatology · 2026
    23. Skin, eye and other problems Journal of the European Academy of Dermatology and Venereology · 2019
    24. New treatments for rheumatoid arthritis Postgraduate Medicine · 1999 · 13 citations
    25. Drug News ​​​​​​​​​​​​​​Nursing2023 · 2017
    26. Drug Repurposing Patent Applications April–June 2021 Assay and drug development technologies · 2021
    27. A functional polymorphism in interleukin-1α (IL1A) gene is associated with risk of alopecia areata in Chinese populations Gene · 2013 · 11 citations
    28. Das weiße Hautfettgewebe initiiert die IL-33-abhängige Expression von Interleukin 4/13 in myeloischen Zellen während einer Entzündung Qucosa (Saxon State and University Library Dresden) · 2024
    29. Topische Immuntherapie mit Diphenylcyclopropenon bei verschiedenen Typen der Alpecia areata: Assoziation zu klinischen Parametern und einem funktionellen Genpolymorphismus des Interleukin-6-Promotors Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · 2005
    30. Repigmentation and new growth of hairs after anti–interleukin-17 therapy with secukinumab for psoriasis JAAD Case Reports · 2018 · 12 citations